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NTIS 바로가기한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, v.38 no.1, 2009년, pp.32 - 38
진휘승 (정산생명공학연구소(주)) , 박금주 (정산생명공학연구소(주)) , 박승희 (정산생명공학연구소(주)) , 김재기 (정산생명공학연구소(주))
In this study, we investigated the anti-obesity activity of the herbal extract mixture (HEM). The inhibitory effect of HEM on triglyceride accumulation of 3T3-L1 preadipocyte was examined by Oil-Red O staining. HEM inhibited the triglyceride accumulation of 3T3-L1 preadipocyte cell and reduced glyce...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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비만의 문제점은? | 세계보건협회는 2010년에는 서양인의 약 50%가 비만으로 될 가능성이 높은 것으로 예상하고 있으며, 우리나라에서도 시간이 지날수록 비만인이 크게 증가할 것으로 예상하고 있다. 비만은 외형적인 문제뿐만 아니라, 과체중으로 인하여 고혈압, 고지혈증, 동맥경화, 심장질환, 제2형 당뇨병 등과 같은 성인병 발병률 또한 증가시킨다고 보고되어져 있다(1,2). | |
비만 유발 원인은? | 비만 유발 원인으로는 과도한 지방세포의 분화 증가, 에너지 섭취와 소비간의 불균형으로 인한 체내 지방 축적 증가가 주된 원인으로 알려져 있으며, 그 외 유전적 요인 등 복합적인 원인으로 인하여 유발이 되며 비만과 연관된 질병의 이해와 치료를 위해 지방세포의 분화와 지방대사에 대한 연구가 활발히 진행되고 있다(3-5). | |
지유, 옥발, 적하수오 및 삼백초를 이용해 만든 HEM은 GPDH 효소에 어떤작용을 하여 비만의 예방을 도왔는가? | 민간요법 중에서 비만 치료에 사용되는 4종의 식물인 지유, 옥발, 적하수오 및 삼백초를 동량으로 혼합하여 10배의 물을 사용하여 가열추출 후 감압농축 하여 HEM을 조제하였고, 이렇게 조제된 HEM을 사용하여 0~100 μg/mL 농도로 3T3-L1의 지방축적 억제율을 측정한 결과 농도가 증가함에 따라 유의적으로 증가하였으며, 동일 농도에서 세포독성은 없었다. 또한 지방 축적에 관여하는 효소인 GPDH의 활성을 억제함으로써 세포내 지방이 축적되는 것을 억제하였다. 5주간의 동물실험 결과 대조군과 비교하여 HEM1과 HEM2군 모두 체중 변화와 식이효율이 줄어드는 것으로 나타났으며, 혈액 분석에서 HEM군은 혈중 중성지방과 총콜레스테롤에 효과를 보이지 않았다. |
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