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NTIS 바로가기韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.17 no.2, 2009년, pp.90 - 96
The objective of this study was to investigate the effect of crude ginseng total saponins (CGS) against airway inflammation (AI) and airway hyperresponsiveness (AH) induced by diesel exhaust particles (DEP) in mice. AI and AH were induced by the intratracheal instillation with 0.1
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핵심어 | 질문 | 논문에서 추출한 답변 |
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디젤배기가스입자를 항원과 함께 생쥐에 투여하면 호흡기에 어떤 영향을 주는가? | , 2004). 그리고 디젤배기가스 입자를 항원과 함께 생쥐에 투여했을 때 기관지천식의 증상인 세기관지가 광범위하게 좁아지는 현상이 나타내며, 발작성인 호흡곤란이 자연적으로 혹은 치료에 의해서 원 상태로 되돌아가는 가역성의 성질을 보이고, 작은 자극에 의해서도 예민하게 기도과민성이 항진되며, 점액성분이 과다 분비된다고 보고되고 있다 (Lim & Lee, 2002; Lim et al., 1998 Sagai et al. | |
경유차 매연에 포함된 미세먼지는 무엇을 함유하는가? | 003~0.1 ㎛)는 black carbon, hydrocarbons (C14-C35)과 그 유도체, heterocyclics, polycyclic aromatic hydrocarbons과 그 유도체, acids, alcohols, esters anhydrides, ketones, nitriles, quinones, sulfonates, organic halogens과 nitrates, inorganic sulfates와 nitrates 및 중금속 등을 함유하고 있으며 (Akiyama, 2007), 기도염증, 암이나 기관지 천식 등 알레르기성 만성호흡기 질환의 직접적인 원인이 된다고 보고되고 있다 (Inoue et al., 2008; Wichmann, 2007). | |
현대 의학에서 사포닌의 효과는? | 예로부터 우리나라 인삼은 강장제로서 ‘체내의 오장을 보하며, 정신을 안정시키고, 장복하면 몸이 가뿐하게 되어 수명이 길어진다’고 많은 고서에서 기술되어 있다. 또한 현대 의학에서도 인삼에 함유돼 있는 성분인 사포닌은 항 피로, 혈당치 강하, 용혈작용, 면역기능 증진 및 항암작용에 효과가 있다고 보고되고 있다 (Choi, 2008; Kang et al., 2008; Lim, 2007). |
Akiyama K. (2006). Gas chromatographic analysis and aerosol mass spectrometer measurement of diesel exhaust particles composition. Talanta. 70:178-181
Cho YS, Lee JT, Jung CH, Chun YS and Kim YS. (2008). Relation between particulate matter measured by optical particle counter and mortality in Seoul, Korea, during 2001. Journal of Environmental Health. 71:37-43
Choi KT. (2008). Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng CA Meyer. Acta Pharmacologica Sinica. 29:1109-1118
Finkelman FD, Yang M, Orekhova T, Clyne E, Nerbstein J, Whitekus M, Diaz-Sabchez D and Morris SC. (2004). Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells. The Journal of Immunology. 172:3808-3813
Finotto S, De Sanctis GT, Lehr HA, Herz U, Buerke M, Schipp M, Bartsch B, Atreya R, Schmitt E, Galle PR, Renz H and Neurath MF. (2001). Treatment of allergic airway inflammation and hyperrespon- siveness by antisense-induced local blockade of GATA-3 expression. The Journal of Experimental Medicine. 193:1247-1260
Gowdy K, Krantz QT, Daniels M, Linak WP, Jaspers I and Gilmour MI. (2008). Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust. Toxicology and Applied Pharmacology. 229:310-319
Hammond H, De Vries VC, Maldonado-Lopez R, Moser M, Maliszewski C, Hoogsteden HC and Lambrecht BN. (2004). Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung. Allergy. 12:1834-1840
Hofseth LJ and Wargovich MJ. (2007). Inflammation, cancer, and targets of ginseng. Journal of Nutrition. 137:183S-185S
Inoue KI, Koike E, Yanagisawa R and Takano H. (2008). Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in ahmatic mice. Immunopharmacology and Immunotoxicology. 28:1-6
Kang KA, Kang JH and Yang MP. (2008). Ginseng total saponin enhances the phagocytic capacity of canine peripheral blood phagocytes in vitro. The American Journal of Chinese Medicine. 36:329-341
Kang KS, Yokozawa T, Yamabe N, Kim HY and Park JH. (2007). ESR study on the structure and hydroxyl radical scavenging activity relationships of ginsenosides isolated from Panax ginseng C.A. Meyer. Biological Pharmaceutical Bulletin. 30:917-921
Lim HB. (2007). Modulation of cytochrome P-450 induction by long-term supplementation with Korean red ginseng to rats. Korean Journal of Medicinal Crop Science. 15:437-443
Lim HB, Ichinose T, Miyabara Y, Takano H, Kumagai Y, Shimojyo N and Sagai M. (1998). Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radical Biology and Medicine. 25:635-644
Lim HB and Lee DW. (2006). The effect of Korean red ginseng water- extract on aging-related changes in the xenobiotic metabolizing enzyme system in the liver of rats. Korean Journal of Medicinal Crop Science. 14:329-335
Lim S, Yoon JW, Choi SH, Cho BJ, Kim JT, Chang HS, Park HS, Park KS, Lee HK, Kim YB and Jang HC. (2009b). Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulinresistant rat model. Metabolism. 58:8-15
Liu J, Ballaney M, Alalem U, Quan C, Jin X, Perera F, Chen LC and Miller RL. (2008). Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T healper genes and IgE production in vivo. Toxicological Science. 102:76-81
Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S and Sugawara I. (2008). Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clinical Immunology. 128:366-373
Nakajima H and Takatsu K. (2007). Role of cytokines in allergic airway inflammation. International Archives of Allergy and Immunology. 142:265-273
Pawankar R, Lee KH, Nonaka N and Takizawa R. (2007). Role of mast cells and basophils in chronic rhinosinusitis. Clinical Allergy and Immunology. 20:93-101
Ris C. (2007). US EPA health assessment for diesel engine exhaust : a review. Inhalation Toxicology. 19:229-39
Sagai M, Saito H, Ichinose T, Kodama M and Mori Y. (1993). Biological effects of diesel exhaust particles. I. In vitro production od superoxide and in vivo toxicity in mouse. Free Radical Biology and Medicine. 14:37-47
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Shen HH, Wang K, Li W, Ying YH, Gao GX, Li XB and Huang HQ. (2008). Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition. Journal of Ethnopharmacology. 116:363-369
Shigh BB, Khorsan R, Vinjamury SP, Der-Martirosian C, Kizhakkeveettil A and Anderson TM. (2007). Herbal treatments of asthma : a systematic review. Journal of Asthma. 44:685-698
Takano H, Lim HB, Miyabara Y, Ichinose T, Yoshikawa T and Sagai M. (1999). Modulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice. Toxicology. 139:19-26
Takizawa H. (2003). Role of inflammatory cells in the development of airway inflammation. Nippon Rinsho Journal. 61:2107-2112
Theoharides TC and Kalogeromitros D. (2006). The critical role of mast cells in allergy and inflammation. Annals of New York Academy of Science. 1088:78-99
Vig, RS, Forsythe P and Vliagoftis H. (2006). The role of stress in asthma : insite from studies on the effect of acute and chronic stressors in models of airway inflammation. Annals of New York Academy of Science. 1088:65-77
Wichmann HE. (2007). Diesel exhaust particles. Inhalation Toxicology. 19:241-244
Yang EJ, Lee JS, Yun CY, Kim JH, Kim JS, Kim DH and Kim IS. (2008). Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in a mouses model of asthma. Journal of Ethnopharmacology. 118:102-107
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