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NTIS 바로가기한국식품과학회지 = Korean journal of food science and technology, v.41 no.3 = no.205, 2009년, pp.320 - 325
홍순기 (KT&G 중앙연구원) , 박채규 (KT&G 중앙연구원) , 이미자 (KT&G 중앙연구원) , 정신교 (경북대학교 농업생명과학대학) , 이영호 ((주)일신웰스) , 현선희 (KT&G 중앙연구원)
The present study was carried out to investigate the acute oral toxicity and anti-obesity effects of a diglyceride preparation containing conjugated linoleic acid (DG+CLA). To test its acute oral toxicity, the DG+CLA was injected into 30 rats (15 males and 15 females) at dosage of 2,000 mg/kg and 5,...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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합성된 Conjugated linoleic acid는 어떤 증상에 우수한 효과를 나타내는가? | 화학적으로 linoleic acid로부터 합성한 CLA는 c9, t11-CLA 이성체와 t10, c12-CLA 이성체가 각각 48% 정도로 합성되며, 나머지는 미량으로 함유되어 있다. 합성된 CLA는 동맥경화증의 발생저하(6), 면역기능 향상(7), 항암작용(5,8), 성장촉진(9), 항산화및 고혈당 등의 증상에 대해 우수한 효과를 나타내며, 체지방감소(10)를 통해 비만을 억제한다고도 알려져 있다. Balb/C mice을 대상으로 CLA(0. | |
Conjugated linoleic acid는 무엇인가? | Conjugated linoleic acid(CLA)는 자연적으로 유제품이나 쇠고기에 존재하며, n-6계 필수지방산인 linoleic acid(C18:2n-6)로부터 생성된 공여 이중결합을 갖는 이성체이다(1-4). CLA는 1987년 Ha 등(5)이 c9, c11-, t9, c11-, t9, t11-, c10, c12-, t10, c12- 및 t10, t12-CLA 등 8개 이성체 혼합물을 종합적으로 CLA라 명명하였다. | |
화학적으로 linoleic acid로부터 합성한 CLA는 어떤 물질로 합성되어있는가? | CLA는 1987년 Ha 등(5)이 c9, c11-, t9, c11-, t9, t11-, c10, c12-, t10, c12- 및 t10, t12-CLA 등 8개 이성체 혼합물을 종합적으로 CLA라 명명하였다. 화학적으로 linoleic acid로부터 합성한 CLA는 c9, t11-CLA 이성체와 t10, c12-CLA 이성체가 각각 48% 정도로 합성되며, 나머지는 미량으로 함유되어 있다. 합성된 CLA는 동맥경화증의 발생저하(6), 면역기능 향상(7), 항암작용(5,8), 성장촉진(9), 항산화및 고혈당 등의 증상에 대해 우수한 효과를 나타내며, 체지방감소(10)를 통해 비만을 억제한다고도 알려져 있다. |
Kelly GS. Conjugated linoleic acid: A review. Altern. Med. Rev. 6: 367-384 (2001)
Nakamura MT, Nara TY. Structure, function, and dietary regulation of ${\Delta}6$ , ${\Delta}5$ , and ${\Delta}9$ desaturases. Annu. Rev. Nutr. 24: 345-376 (2004)
Joseph AS, Miller GD. Potential health benefits of conjugated linoleic acid. J. Nutr. 19: 470S-471S (2000)
Lin TY. Conjugated linoleic acid concentration as affected by lactic cultures and added linoleic acid. Food Chem. 67: 1-3 (1999)
Ha YL, Grimm NK, Pariza MW. Anticarcinogens from fried ground beer: Heat-altered derivatives of linoleic acid. Carcinogenesis 8: 1881-1887 (1987)
Gniwotta C, Morrow JD, Roberts LJ, Kuhn H. Prostaglandin F2- like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. Arterioscl. Throm. Vas. 17: 3236-3241 (1997)
Pariza MW, Ha YL, Benjamin H, Sword JT, Gruter A, Chin SF, Storkson J, Faith N, Albright K. Formation and action of anticarcinogenic fatty acids. Adv. Exp. Med. Biol. 289: 269-272 (1991)
Macdonald HB. Conjugated linoleic acid and disease prevention: A review of current knowledge. J. Nutr. 19: 111S-118S (2000)
Sugano M, Tsujita A, Yamasaki M, Yamada K, Ikeda I, Kritchevsky D. Lymphaticrecovery, tissue distribution and metabolic effects of conjugated linoleic acid in rats. J. Nutr. Biochem. 8: 38-43 (1997)
Yurawecz MP, Hood JK, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 19-25 (1995)
Terpstra AH, Javadi M, Beynen AC, Kocsis S, Lankhorst AE, Lemmens AG, Mohede IC. Dietary conjugated linoleic acids as free fatty acids and triacyglycerols similarly affect body composition and energy balance in mice. J. Nutr. 133: 3181-3186 (2003)
Yamasaki M, Mansho K, Mishima H, Kasai M, Sugano M, Tachibana H, Yamada K. Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of sprague-dawley rats. Biosci. Biotechnol. Biochem. 63: 1104-1106 (1999)
Gaullier JM, Halse J, Hφye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J. Nutr. 135: 778-784 (2005)
Riserus U, Berglund L, Vessby B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrom: A randomised controlled trial. Int. J. Obesity 25: 1129-1135 (2001)
Gaullier JM, Halse J, Hφivik HO, Hoye K, Syvertsen C, Nurminiemi M, Hassfeld C, Einerhand A, O'Shea M, Gudmundsen O. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Brit. J. Nutr. 97: 550-560 (2007)
Kamphuis MM, Lejeune MP, Saris WH, Westerterp-Plantenga MS. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int. J. Obesity 27: 840-847 (2003)
Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids 36: 773-781 (2001)
Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J. Int. Med. Res. 29: 392-396 (2001)
Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, Tsigilis N, Nikolaidis M. Effect of supplementation with conjugted linoleic acid on human serum lipids and body fat. J. Nutr. Biochem. 12: 585-594 (2001)
Nagao K, Wang YM, Inoue N, Han SY, Buang Y, Noda T, Kouda N, OKamatsu H, Yanagita T. The 10-trans, 12-cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. Nutrition 19: 652-656 (2003)
Scimeca JA. Toxicological evaluation of dietary conjugated linoleic acid in male fischer 344 Rats. Food Chem. Toxicol. 36: 391-395 (1998)
O'Hagan S, Menzel A. A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product. Food Chem. Toxicol. 41: 1749-1760 (2003)
Yang M, Cook ME. Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-a production, and modifies splenocyte cytokines production. Exp. Biol. Med. 228: 51-58 (2003)
Bontempo V, Sciannimanico D, Pastorelli G, Rossi R, Rosi F, Corino C. Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets. J. Nutr. 134: 817-824 (2004)
Soni MG, Kimura H, Burdock GA. Chronic study of diacylglycerol oil in rats. Food Chem. Toxicol. 39: 317-329 (2001)
Chengelis CP, Kirkpatrick JB, Marit GB, Morita O, Tamaki Y, Suzuki H. A chronic dietary toxicity study of DAG (diacylglycerol) in Beagle dogs. Food Chem. Toxicol. 44: 81-97 (2006)
Kasamatsu T, Ogura R, Ikeda N, Morita O, Saigo K, Watabe H, Saito Y, Suzuki H. Genotoxicity studies on dietary diacylglycerol (DAG) oil. Food Chem. Toxicol. 43: 253-260 (2005)
Takei A, Toi T, Takahashi H, Takeda Y, Moriwaki J, Takase H, Katsuragi Y. Effects of diacylgcerol-containing mayonnaise on lipid metabolism and body fat in human. Jpn. Nutr. Food 4: 89-94 (2001)
Watanabe H, Tokimitsu I. Digestion and absorption of diacylglycerol. p.30. In: Diacylglycerol Oil, Katsuragi Y, Yasukawa T, Matsuo N, Flickinger BD, Toimitsu I, Matlok MG (eds). American Oil Chemistsi Society, Champaign, IL, USA (2004)
Matsuyama T, Shoji K, Watanabe H, Shimizu M, Saotome Y, Nagao T, Matsuo N, Hase T, Tokimitsu I, Nakaya N. Effects of diacylglycerol oil on adiposity in obese children: Initial communication. J. Pediatr. Endoc. Met. 19: 795-804 (2006)
Teramoto T, Watanabe H, Ito K, Omata Y, Furukawa T, Shimoda K, Hoshino M, Nagao T, Naito S. Significant effects of diacylglycerol on body fat and lipid metabolism in patients on hemodialysis. Clin. Nutr. 23: 1122-1126 (2004)
Maki KC, Davidson MH, Tsushima R, Matsuo N, Tokimitsu I, Umporowicz DM, Dicklin MR, Foster GS, Ingram KA, Anderson BD, Frost SD, Bell M. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. Am. J. Clin. Nutr. 76: 1230-1236 (2002)
Nagao T, Watanabe H, Goto N, Onizawa K, Taguchi H, Matsuo N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J. Nutr. 130: 792-797 (2002)
Yasunaga K, Glinsmann WH, Seo Y, Katsuragi Y, Kobayashi S, Flickinger B, Kennepohl E, Yasukawa T, Borzelleca JF. Safety aspects regarding the consumption of high-dose dietary diacylglycerol oil in men and women in a double-blind controlled trial in comparison with consumption of a triacylglycerol control oil. Food Chem. Toxicol. 42: 1419-1429 (2004)
Moon HS, Lee HG, Seo JH, Chung CS, Kim TG, Kim IY, Lim KW, Seo SJ, Choi YJ, Cho CS. Down-regulation of PPARgamma2- induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. Arch. Biochem. Biophys. 456:19-29 (2006)
Normen L, Dutta P, Lia A, Andersson H. Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am. J. Clin. Nutr. 71: 908-913 (2000)
Becker M, Staab D, von Bergman K. Long-term treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J. Pediatr. 122: 292-296 (1993)
Watanabe H, Onizawa K, Taguchi H, Kobori M, Chiba H, Naito S, Matsuo N, Yasukawa T, Hattori M, Shimasaki H. Nutritional characterization of diacylglycerols in rats. J. Jpn. Oil Chem. 46: 301-307(1997)
Yasukawa T, Yasunaga K. Nutritional functions of dietary diacylglycerols. J. Oleo Sci. 50: 427-432 (2001)
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