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논문 상세정보

Streptozotocin 유도 흰쥐에서 참당귀(Angelica gigas Naki) 추출물의 당뇨 개선 효과

Hypoglycemic Effect of Angelica gigas Naki Extract in Streptozotocin-induced Diabetic Rats

Abstract

This study examined the possible hypoglycemic effects Angelica gigas Naki extracts in streptozotocin-induced diabetic rats(STZ+50%, STZ+100% EtOH and STZ+water). The studies showed that administration of the Angelica gigas Naki extract decreased high blood glucose levels(more than 300 mg/$d{\ell}$) to a normal level(104 mg/$d{\ell}$) in the STZ+50% EtOH group. Liver glucokinase levels were significantly increased in STZ+50% EtOH and STZ+100% EtOH groups compared to the STZ group. Moreover, the liver acetyl CoA carboxylase level was significantly increased in STZ+50% EtOH, STZ+100% EtOH and STZ+water groups compared to the STZ group. These results suggest that the Angelica gigas Naki extract in the STZ+50% EtOH group exerted an ameliorable effect and can be used as an anti-diabetic substance, either as a dietary supplements or as a new drug.

참고문헌 (15)

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이 논문을 인용한 문헌 (7)

  1. Kim, Dae-Jung ; Kim, Jeong-Mi ; Kim, Tae-Hyuck ; Baek, Jong-Mi ; Kim, Hyun-Sook ; Choe, Myeon 2010. "Anti-diabetic Effects of Mixed Extracts from Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus" 韓國資源植物學會誌 = Korean journal of plant resources, 23(5): 423~429 
  2. Lee, Ju-Taek ; Ryu, Jae-Sung ; Kwak, Dong-Hoon ; Park, Yun-Jum ; Kang, Seong-Sun ; Kim, Pyoung-Jun ; Hwang, Kyung-A ; Choo, Young-Kug 2010. "Effect of Buan Mulberry on Metabolic Improvement in Streptozotocin-Induced Diabetic Rats" 생명과학회지 = Journal of life science, 20(12): 1750~1757 
  3. 2010. "" Nutrition research and practice, 4(5): 438~442 
  4. Kim, Ae-Jeung ; Rho, Jeong-Ok 2011. "The Quality Characteristics of Jelly added with Black Garlic Concentrate" 한국생활과학회지 = Korean journal of human ecology, 20(2): 467~473 
  5. Yu, Dong-Jo ; Yoon, Gyeong-Min ; Kang, Seok-Bong 2011. "Effects of Hwangryungeehwang-tang Aqueous Extracts on Streptozotocin-induced Diabetic Rat" 대한한방내과학회지 = The journal of internal Korean medicine, 32(2): 288~300 
  6. Park, Yu-Hwa ; Lim, Sang-Hyun ; Kim, Hee-Yeon ; Park, Min-Hee ; Lee, Kwang-Jae ; Kim, Kyung-Hee ; Kim, Young-Guk ; Ahn, Young-Sup 2011. "Biological Activities of Extracts from Flowers of Angelica gigas Nakai" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(8): 1079~1085 
  7. Han, Hyo-Sang 2013. "Anti-inflammatory Effect of Angelicae Gigantis Radix Water Extract on LPS-stimulated Mouse Macrophages" 大韓本草學會誌 = The Korea journal of herbology, 28(5): 113~119 

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