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논문 상세정보

사염화탄소로 간 손상이 유발된 흰쥐에서 황금(黃芩) 열수 추출물이 면역작용에 미치는 효과

The Protective Effects of Scutellaria baicalensis Georgi Water Extracts on the Immunomodulatory Effects on Liver Damage Induced by Carbon Tetrachloride in Rats

Abstract

GATA-binding protein-3 (GATA-3) and T-box expressed in T-cells (T-bet) are now considered as master transcription factors involving Th cell differentiation, but the roles of these factors are still uncertain in vivo. This study was conducted to investigate the expression of these transcription factors in the liver damage induced by carbon tetrachloride ($CCl_4$) in rats. In this study, liver damage were induced with Scutellaria baicalensis Georgi water extracts (SBW) and followed for 4 weeks. The expression of GATA-3 and T-bet protein in liver damage induced by $CCl_4$ and the serum levels of immunoglobulin A (IgA), IgE were studied after 4 weeks of treatment. We found that effect of SBW on IFN-$\gamma$, STAT1, pSTAT1 and T-bet was decreased in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. $CCl_4$+SBW group was significantly lower than $CCl_4$ group in IL-4, STAT6, pSTAT6 and GATA-3. Our data indicate that cytokine protein production were increased in $CCl_4$ group and $CCl_4$+SBW group. From these results, water extracts obtained from Scutellaria baicalensis Georgi may have an immunoregulatory effect in the liver induced by $CCl_4$ of rats.

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이 논문을 인용한 문헌 (1)

  1. Bai, Sang-Kyoung 2010. "Dyeing properties of rayon and cotton fabrics with Scutellaria baicalensis Georgi" 패션비즈니스 = Fashion business, 14(4): 174~184 

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