Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administe...
Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.
Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.
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제안 방법
A total of 16 rats were divided into four groups: vehicle-treated low-fat diet control (LFD, n = 4), vehicle-treated high-fat diet control (HFD, n = 4), 100mg/kg LE extract-treated high-fat diet (LE100, n = 4), and 250 mg/kg LE extract-treated high-fat diet (LE250, n = 4 ).
The aim of the present study was to evaluate the anti-obesity activity of a LE extract in rats, examining body weight, food intake, lipid profiles, and hepatic function markers in blood and in liver tissue.
대상 데이터
Sprague-Dawley rats (6-week-old male rats weighing 169.3 ± 1.25 g) were purchased from the animal center of the Korea Research Institute of Bioscience and Biotechnology (Seoul, Korea).
데이터처리
The data represent means ± S.E. The data were analyzed using one-way analysis of variance (ANOVA), followed by a Tukey-Kramer post hoc test for multiple comparisons.
성능/효과
Serum ALT concentration was significantly increased in the HFD group (295.1 ± 17.1) (p < 0.05) compared with the LFD group (167.4 ± 17.9), while that in the LE250 group was significantly decreased (160.2 ± 25.6) (p < 0.05) relative to those of the LE100 and HFD groups (Table 1).
Serum T-CHO, LDL, and HDL levels were significantly higher in the HFD group compared to the LFD group (p < 0.05), respectively.
Taken together, our results demonstrate that LE extract has hepatoprotective, hypolipidemic, and anti-obesity effects in HFD-induced rat obesity.
The rate of weight gain was shown to be significantly increased in rats in the vehicle-treated HFD group, as compared to that of the vehicle-treated LFD group (p < 0.05).
The weight of epididymal WAT was significantly increased in the vehicle-treated HFD group compared with those of vehicle-treated LFD group; the weight of epididymal WAT in the LE250 group, but not the LE100 group, was significantly reduced compared with that of HFD controls (p < 0.05) (Fig. 3).
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