[논문]The Effect of Codium fragile (Chlorophyta) Extract on Hepatic Dysfunction and Hyperlipidemia in Rats

Park, Kap-Joo; Hwang, Eun-Kyoung; Park, Chan-Sun; Cho, Myung-Hwan; Lee, Jae-Seok

The Effect of Codium fragile (Chlorophyta) Extract on Hepatic Dysfunction and Hyperlipidemia in Rats 원문보기

환경생물 = Korean journal of environmental biology, v.28 no.2, 2010년, pp.79 - 85

Park, Kap-Joo (Department of Biological Sciences, Konkuk University) , Hwang, Eun-Kyoung (Seaweed Research Center, NFRDI) , Park, Chan-Sun (Department of Marine Resources, Mokpo National University) , Cho, Myung-Hwan (Department of Biological Sciences, Konkuk University) , Lee, Jae-Seok (Department of Biological Sciences, Konkuk University)

Abstract ▼ AI-Helper

To examine the effect of Codium fragile on blood cholesterol and lipid metabolism, hyperlipidemia was induced in experimental animal rats through the administration of a hypercholesterolemic diet. Codium fragile powder was then administered to the rats for 5 weeks, after which, blood biochemical changes such as blood cholesterol, Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) enzyme activity, etc. were determined. And histological changes in liver cells were examined using an electron microscope. Codium fragile treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride and low-density cholesterol (LDL. Chol) compared to the control rats. In contrast the expression levels of high-density cholesterol (HDL. chol.) were increased. The AST value of the Codium fragile administration group was significantly reduced and the blood ALT value of the Codium fragile group showed a significant decrease in comparison to the negative control group. In summary, this study demonstrated the beneficial possibilities of Codium fragile in improving the abnormality of lipid metabolism caused by liver cell damage and hyperlipidemia.

주제어

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제안 방법

This study was therefore conducted to elucidate the effects of Codium fragile on hepatic function damaged by hyperlipidemia and elevated blood lipid concentrations in rats. Codium fragile extract was administered to rats that were previously maintained on a high-fat diet so as to induce hyperlipidemia.

대상 데이터

As experiment animals, 32 Sprague Dawley male rats, 4 weeks of age, with an average weight of 79.29 1.73 g were obtained from Daehan Biolink Co., Ltd. (Seoul). The animals were allowed to adapt to the animal facility for 1 week.

데이터처리

Statistical evaluation of data was performed by Duncan’s multiple range test to make comparisons between groups.

성능/효과

Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) activities were measured. Also, the serum major lipid components, i.e. triglycerides, total cholesterol (T. chol.), lowdensity cholesterol (LDL. chol.), and high-density cholesterol (HDL. chol.) activity were measured.
Comparing the positive control group (55.50±9.98 mg dL-1) and the experimental group (68.75±12.53 mg dL-1) with the negative control group, the value of LDLcholesterol was significantly decreased.
21 U L^-1. In this study, the Codium fragile administration group exhibited significantly reduced AST and ALT levels compared to the negative control group. These data suggest the possibility of Codium fragile being an excellent candidate to ameliorate the effect of hepatocytes and anti-hyperlipidemia from high fat diet-mediated damage in the rat.
On the other hand, the positive group was 12.13±0.56%, and a slightly reduced value was shown, and the ratio of body weight and the liver in the experimental group was shown to be 12.15±0.62%, and a significant decreased was shown in comparison with the normal group and the negative control group.
The final weight change of the normal group and the negative control group was shown to be 307.11±5.24 g and 329.34±19.58 g, respectively.

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