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NTIS 바로가기Korean journal of pediatrics, v.53 no.4, 2010년, pp.481 - 487
Purpose: Recently many studies show early exposure during childhood growth to endotoxin (lipopolysaccharides, LPS) and/or early exposure to allergens exhibit important role in development of allergy including bronchial asthma. The aim of this study was to evaluate the role of endotoxin and allergen ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
위생가설에 근거해 설명할 수 있는 질환 및 현상은? | 지난 30여 년간에 걸친 알레르기 질환의 유병율의 증가는 한편으로는 소아가 생후 초기에 노출되는 미생물적 부하(microbial burden)의 변화와 관련하여 알레르기 질환 유병율의 증가를 제시한 ‘위생가설’(hygiene hypothesis)에 근거하여 설명될 수 있다1). 천식은 소아에서 가장 흔한 만성 질환이며 이와 동반되는 상당한 병상태(morbidity)를 나타낸다. | |
천식은 무엇인가? | 지난 30여 년간에 걸친 알레르기 질환의 유병율의 증가는 한편으로는 소아가 생후 초기에 노출되는 미생물적 부하(microbial burden)의 변화와 관련하여 알레르기 질환 유병율의 증가를 제시한 ‘위생가설’(hygiene hypothesis)에 근거하여 설명될 수 있다1). 천식은 소아에서 가장 흔한 만성 질환이며 이와 동반되는 상당한 병상태(morbidity)를 나타낸다. 흔한 대기 알레르겐에 의한 기도의 알레르기 감작은 천식과 알레르기비염의 발생과 관련되며 많게는 전 인구의 30%가 이들 질환에 이환된다2). | |
출생 초기에 기도 점막을 통한 알레르겐과 내독소에의 노출이 성장한 후에 알레르기 기도염증과 과반응성의 발생에 미치는 효과를 알아보기 위해 실시한, 실험동물의 비특이적 기도과반응성 검사 결과는? | 결 과 : 1) 메타콜린에 의한 기도과반응성은 생후 초기에 OVA, LPS, OVA/LPS를 투여한 군에서 생리식염수를 투여한 군에 비해 통계적으로 유의하게 억제되었다. 2) OVA, LPS, OVA/LPS를 투여한 군에서 BAL 액내의 호산구수와 IL-4, IL-5가 유의하게 낮았다. 3) 혈청내 OVA 특이 IgE는 OVA, LPS, OVA/LPS 투여군에서 유의하게 감소되었다. |
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