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NTIS 바로가기소아청소년정신의학 = Journal of the Korean Academy of Child and Adolescent Psychiatry, v.21 no.1, 2010년, pp.17 - 22
김현근 (차의과대학교 의학유전체교실) , 원성식 (차의과대학교 의학유전체교실) , 이승구 (차의과대학교 의학유전체교실) , 남민 (이화여자대학교 심리학교실) , 방희정 (이화여자대학교 심리학교실) , 박현정 (이화여자대학교 심리학교실) , 윤진영 (이화여자대학교 심리학교실) , 최경식 (중부대학교 유아특수교육과) , 홍미숙 (경희대학교 약리학교실) , 정주호 (경희대학교 약리학교실) , 곽규범 (차의과대학교 의학유전체교실)
Objectives : Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by abnormalities of social functioning, communication and behavior. The association of the 7q21-34 region with ASD has been reported. The DLX6 gene, which is located at the 7q22 region, is one of the p...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
자폐스펙트럼장애를 어떻게 분류할 수 있는가? | 자폐스펙트럼장애(autism spectrum disorders)는 사회적 상호작용, 의사소통 및 상동적 행동 분야의 발달이 손상된 전반적 발달장애로서 자폐증(autism), 레트장애(Rett’s disorder), 소아기 붕괴장애(childhood disintegrative dis-order), 아스퍼거 증후군(Asperger’s syndrome), 특정불능의 전반적 발달장애로 분류된다. | |
초파리에서 발견된 DLX6 유전자와 같이 연구되고 있는 것은? | DLX6는 초파리(Drosophila melanogaster)에서 발견된 Dlx 유전자군집에 포함되는 유전자들 중 하나로, 동물실험을 통하여 배형성 동안 전뇌 발달에 중요한 조절인자로 알려져 있다. 게다가 신경세포의 활성화를 조절하여 뇌에서 과도한 신경자극을 억제하는 기능을 담당하는 GABAeric sys-tem에 관여하는 유전자들과의 관련성도 연구되었다.32,33) 이는 자폐스펙트럼장애가 신경발달 장애로부터 기인한다는 사실을 고려해 볼 때, DLX6의 유전적 변이가 자폐스펙트럼장애 발병 기전에 관여할 수 있음을 암시한다고 볼 수 있다. | |
자폐스펙트럼장애란 무엇인가? | 자폐스펙트럼장애(autism spectrum disorders)는 사회적 상호작용, 의사소통 및 상동적 행동 분야의 발달이 손상된 전반적 발달장애로서 자폐증(autism), 레트장애(Rett’s disorder), 소아기 붕괴장애(childhood disintegrative dis-order), 아스퍼거 증후군(Asperger’s syndrome), 특정불능의 전반적 발달장애로 분류된다. |
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