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NTIS 바로가기大韓韓醫學會誌 = Journal of Korean Oriental Medicine, v.31 no.1, 2010년, pp.138 - 152
홍정애 (경희대학교 한의과대학 한방재활의학교실) , 송미연 (경희대학교 한의과대학 한방재활의학교실) , 최인화 (경희대학교 한의과대학 안이비인후피부과학교실) , 손락원 (경희대학교 동서의학대학원 신경과학 및 뇌질환) , 정석희 (경희대학교 한의과대학 한방재활의학교실)
Objective: Yikgeebohyul-tang (Yiqib
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핵심어 | 질문 | 논문에서 추출한 답변 |
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모낭은 어떤 특징을 가지고 세포의 증식과 분화를 보이는가? | 毛球는 중간엽 세포인 모유두에 의해 곧 함입되어 毛球의 주위 세포는 뿌리상피집을 형성하며 그 주위를 둘러싸고 있는 중간엽세포는 뿌리진피집으로 분화한다1). 모유두는 모발의 성장에 중요한 역할을 하며 3-5년의 성장기, 1-2개월의 퇴화기, 3-5개월의 휴지기 및 발생기의 모발 성장주기가 있으며2) 모낭은 모유두의 성장 주기별로 뚜렷한 형태학적 특징을 가지고 세포의 증식과 분화를 보인다2,3). 모낭의 성장주기별 변화는 모낭의 면역특권에 의해 가능한 것으로 모낭에서의 면역특권은 자가면역 반응을 피하는데 필수적인 것으로 알려져 있으며, 모낭의 면역특권은 T세포간의 면역평형에 의해 유지된다4). | |
益氣補血湯의 육모촉진 효과를 관찰하기 위하여 제모된 C57BL/6 마우스에 益氣補血湯을 14일간 경구투여한 다음 육안적 발모상태 및 발모면적, 모발 및 모낭의 조직학적 변화, 모낭에서의 TGF-β1 및 EGF 발현을 면역조직화학염색을 통해 관찰하였다. 또한 혈청에서의 IFN-γ, IL-4, IL-10의 변화에 대해서 관찰하여 얻은 결과는? | 1. 발모면적비율에서 유의성 있는 증가를 나타내었다. 2. 모발의 밀도, 성모의 수 및 성모 비율에서 유의성 있는 증가를 나타내었다. 3. 대조군과 益氣補血湯 투여군 모두에서 모낭의 TGF-β1은 관찰되지 않았다. 4. 모낭에서 EGF의 발현을 增加시켰다. 5. 혈청 IFN-γ는 실험 7일째 유의하게 감소되었으며 실험 14일째는 감소되었으나 유의성은 없었다. 6. 혈청 IL-4는 실험 7일째는 유의하게 증가되었으며 실험 14일째는 증가되었으나 유의성은 없었다. 7. 혈청 IL-10은 감소되었으나 유의성은 없었다. | |
모유두는 어떤 역할을 하는가? | 毛球는 중간엽 세포인 모유두에 의해 곧 함입되어 毛球의 주위 세포는 뿌리상피집을 형성하며 그 주위를 둘러싸고 있는 중간엽세포는 뿌리진피집으로 분화한다1). 모유두는 모발의 성장에 중요한 역할을 하며 3-5년의 성장기, 1-2개월의 퇴화기, 3-5개월의 휴지기 및 발생기의 모발 성장주기가 있으며2) 모낭은 모유두의 성장 주기별로 뚜렷한 형태학적 특징을 가지고 세포의 증식과 분화를 보인다2,3). 모낭의 성장주기별 변화는 모낭의 면역특권에 의해 가능한 것으로 모낭에서의 면역특권은 자가면역 반응을 피하는데 필수적인 것으로 알려져 있으며, 모낭의 면역특권은 T세포간의 면역평형에 의해 유지된다4). |
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