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한국임상약학회지 = Korean journal of clinical pharmacy, v.20 no.2, 2010년, pp.128 - 137
김현주 (이화여자대학교 생명.약학부) , 최종민 (이화여자대학교 생명.약학부) , 김유진 (이화여자대학교 생명.약학부) , 채송화 (이화여자대학교 생명.약학부) , 박정현 (이화여자대학교 생명.약학부) , 오지현 (이화여자대학교 생명.약학부) , 김경희 (이화여자대학교 생명.약학부) , 허정선 (이화여자대학교 생명.약학부) , 곽혜선 (이화여자대학교 생명.약학부) , 이화정 (이화여자대학교 생명.약학부)
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This review summarizes gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions. Gender differences in pharmacokinetics are categorized by four major factors: absorption/bioavailability, distribution, metabolism, and elimination. There are sex-based differences in gastric...
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| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 배설에서 성별차이가 나타나는 이유는 어떠한 것에 기인하는가? | 배설에서 성별차이가 나타나는 이유는 주로 사구체 여과율과 유기양이온 수송체 활성의 차이에서 기인한다. 여성의 사구체 여과율은 체중으로 보정을 해도 남성보다 10% 정도 낮기 때문에21) digoxin의 클리어런스는 여성이 남성보다 12%~14% 낮고,22) 주로 신장으로 배설되는 항생제들의 클리어런스도 남성보다 여성이 낮다. | |
| 약물동태학적 성별차이를 유발하는 요인들에는 어떠한 것들이 있는가? | 약물동태학적 성별차이를 유발하는 요인은 아래와 같이 약물의 흡수, 분포, 대사 및 배설에 관련된 요인들로 나눌 수 있다. | |
| Digitalis를 여성들에게 투여한 경우 투여하지 않은 환자에 비해 사망률이 더 증가하는 이유는 무엇인가? | 46-49) Digitalis는 남성과 달리 여성에서는 본 약물을 투여한 경우 그렇지 않은 환자에 비해 사망률이 더 증가한다는 보고가 있다.50) 이는 여성에 있어 Na+ pump의 활성이 낮기 때문에 남성과 동일한 용량의 약물 투여 시 치명적 부정맥이 증가하여 사망률을 증가시키기 때문인 것으로 알려져 있다.51-53) 또한 여성의 경우 남성에 비해 저용량을 투여해도 ( 남성: 0.25 mg/day vs. 여성: 0.22 mg/day) 혈중 농도가 남성보다 높게 (남성: 0.8 ng/mL vs. 여성: 0.9 ng/mL) 나타나는 것으로 보고되었다. 따라서 혈중농도는 남녀 모두 0. |
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