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NTIS 바로가기소아청소년정신의학 = Journal of the Korean Academy of Child and Adolescent Psychiatry, v.22 no.4, 2011년, pp.253 - 261
유한익 (서울뇌과학연구소) , 김봉석 (인제대학교 의과대학 상계백병원 정신과학교실) , 정유숙 (성균관대학교 의과대학 삼성서울병원 정신과학교실) , 반건호 (경희대학교 의학전문대학원 정신과학교실) , 송동호 (연세대학교 의과대학 의학행동과학연구소 및 세브란스 어린이병원 소아정신과학교실) , 안동현 (한양대학교 의과대학 정신과학교실 및 정신건강연구소) , 이영식 (중앙대학교 의과대학 중앙대학교병원 신경정신과학교실)
Objectives : This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neuro-cognitive functions. Methods : Ninety-one subjects w...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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주의력결핍 과잉행동장애의 치료에 사용되는 서방형 제제가 가지는 단점은 무엇인가? | 1) 특히 약물의 작용 시간을 늘린 서방형 제제는 약물 역동학적인 강점과 순응도의 증가 등으로 인해 사용량이 점차 늘어나고 있다.2,3) 하지만 속효성 제제에 비해 효과가 시작되는 시점이 느리고, 부작용이 오랫동안 발생할 가능성이 높은 단점이 있다.4,5) | |
메타데이트 CD란 무엇인가? | 메타데이트 CD(Metadate Controlled Delivery, MCD)는 서방형 메칠페니데이트(methylphenidate, MPH) 제제로서 속방형과 지속형이 일정 비율로 섞여 있는 약물이다. 이 약물은 이미 외국에서 대조군 비교 연구에서 효과와 안전성이 입증되었고, 속방형 MPH와의 교차 연구를 통해서도 효과가 동등하다는 것이 밝혀졌다. | |
ADHD의 핵심 병리는 무엇인가? | 주의력 및 실행기능과 같은 신경인지기능의 저하는 ADHD의 핵심 병리로서 환자의 증상 및 기능 저하와도 밀접하게 연관되어 있다.8) 또한 현재까지의 여러 연구를 통해 ADHD의 증상 개선에 효과가 있는 약물에 의해 신경인지기능도 상당히 변화되는 것으로 알려져 있다. |
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