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NTIS 바로가기韓國營養學會誌 = The Korean journal of nutrition., v.44 no.6, 2011년, pp.498 - 506
김희정 (이화여자대학교 식품영양학과) , 김혜숙 (이화여자대학교 식품영양학과) , 김기남 (이화여자대학교 식품영양학과) , 김꽃핀 (이화여자대학교 식품영양학과) , 손정인 (서울아산병원 정신과) , 김성윤 (서울아산병원 정신과) , 장남수 (이화여자대학교 식품영양학과)
This study examined the relationship among plasma homocysteine, folate, and vitamin
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핵심어 | 질문 | 논문에서 추출한 답변 |
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노인들의 인지기능 저하와 관련된 식품 영양 요인에서 무엇이 가장 주목받는가? | 노인들의 인지기능 저하와 관련된 여러 가지 식품영양 요인 중에서 가장 크게 주목을 받는 요인으로는 단일탄소대사와 관련된 엽산, 비타민 B2, 비타민 B6, 비타민 B12와 같은 비타민 B군의 영양불량상태가 있다. 단일탄소대사에 관여하고 있는 엽산을 비롯한 비타민 B군의 영양불량은 고호모시스테인혈증을 야기시킬 수 있다. | |
고호모시스테인혈증과 관련된 선행연구로 무엇이 있는가? | 단일탄소대사에 관여하고 있는 엽산을 비롯한 비타민 B군의 영양불량은 고호모시스테인혈증을 야기시킬 수 있다. 호모시스테인 수준의 상승은 혈관질환의 위험요인이 됨과 동시에 중추신경계에서는 DNA 손상을 일으키는 것으로 보고되고 있다.4,5) 국외에서 이루어진 많은 cross-sectional study와 population-based longitudinal study들이 높은 호모시스테인 수준과 노인의 인지기능저하와의 관련성,6-10) 혈중호모시스테인에 영향을 미치는 엽산을 비롯한 비타민 B군의 섭취량 및 혈중 수준과 인지기능과의 관련성을 발표하였다.7,11-16) 뿐만 아니라 비타민 B군 보충을 통한 혈중호모시스테인수준 감소에 따라 인지기능에 나타날 수 있는 효과에 대한 중재연구 결과도 보고되고 있다.17-19) | |
노인의 인지기능의 감소가 사회적 문제인 이유는? | 인지기능의 저하는 나이가 들면서 나타나는 자연스런 현상이나,1)노인의 인지기능의 감소는 개인의 삶의 질을 떨어뜨릴 뿐 아니라 주변인들의 삶의 질에도 영향을 미치므로 심각한 사회적 문제로 대두되고 있다. 2010년 통계청이 발표한 [고령자통계]2)에 따르면 우리나라의 경우 현재 11%인 65세 이상의 노인인구비율이 2018년에는 14. |
Smith AD, Earles JL. Memory changes in normal aging. In: Blanchard-Fields F, Hess TM, editors. Perspectives on Cogni tive Change in Adulthood and Aging. New York: McGraw-Hill; 1996. p.192-220
Statistics for elderly population. Daejeon: Statistics Korea; 2010
Oh YH. Living and behavioral differentials of the elderly. Seoul: Korea Institute for Health and Social Affairs (KIHASA); 2010
Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology 2005; 65 (9): 1402-1408
Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002; 22(5): 1752-1762
Garcia A, Zanibbi K. Homocysteine and cognitive function in elderly people. CMAJ 2004; 171(8): 897-904
Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002; 75(5): 908-913
Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005; 82(3): 627-635
Nelson C, Wengreen HJ, Munger RG, Corcoran CD. Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study. J Nutr Health Aging 2009; 13(10): 899-905
Kim JM, Stewart R, Kim SW, Shin IS, Yang SJ, Shin HY, Yoon JS. Changes in folate, vitamin B12 and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry 2008; 79 (8): 864-868
Koike T, Kuzuya M, Kanda S, Okada K, Izawa S, Enoki H, Iguchi A. Raised homocysteine and low folate and vitamin B-12 concentrations predict cognitive decline in community-dwelling older Japanese adults. Clin Nutr 2008; 27(6): 865-871
Stewart R, Asonganyi B, Sherwood R. Plasma homocysteine and cognitive impairment in an older British African-Caribbean population. J Am Geriatr Soc 2002; 50(7): 1227-1232
Kado DM, Karlamangla AS, Huang MH, Troen A, Rowe JW, Selhub J, Seeman TE. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005; 118(2): 161-167
Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology 2001; 56(9): 1188-1194
Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 2007; 64(1): 86-92
Morris MC, Evans DA, Bienias JL, Tangney CC, Hebert LE, Scherr PA, Schneider JA. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005; 62(4): 641-645
Dangour AD, Whitehouse PJ, Rafferty K, Mitchell SA, Smith L, Hawkesworth S, Vellas B. B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review. J Alzheimers Dis 2010; 22(1): 205-224
Balk EM, Raman G, Tatsioni A, Chung M, Lau J, Rosenberg IH. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med 2007; 167(1): 21-30
Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369(9557): 208-216
Lee L, Kang SA, Lee HO, Lee BH, Park JS, Kim JH, Jung IK, Park YJ, Lee JE. Relationships between dietary intake and cognitive function level in Korean elderly people. Public Health 2001; 115(2): 133-138
Han C, Jo SA, Kim NH, Jo I, Park MH. Study design and methods of the Ansan Geriatric Study (AGE study). BMC Neurol 2009; 9: 10
Hoey L, McNulty H, Askin N, Dunne A, Ward M, Pentieva K, Strain J, Molloy AM, Flynn CA, Scott JM. Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am J Clin Nutr 2007; 86(5): 1405-1413
Lee JH, Lee KU, Lee DY, Kim KW, Jhoo JH, Kim JH, Lee KH, Kim SY, Han SH, Woo JI. Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. J Gerontol B Psychol Sci Soc Sci 2002; 57(1): P47-P53
Serving size of food for food intake research. Seoul: Korea Food Industry Association; 1988
Food values. Seoul: The Korean Nutrition Society; 2009
Ravaglia G, Forti P, Maioli F, Muscari A, Sacchetti L, Arnone G, Nativio V, Talerico T, Mariani E. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr 2003; 77(3): 668-673
McCaddon A, Hudson P, Davies G, Hughes A, Williams JH, Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 2001; 12(5): 309-313
Kalmijn S, Launer LJ, Lindemans J, Bots ML, Hofman A, Breteler MM. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol 1999; 150(3): 283-289
Ravaglia G, Forti P, Maioli F, Zanardi V, Dalmonte E, Grossi G, Cucinotta D, Macini P, Caldarera M. Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects. J Nutr Health Aging 2000; 4(4): 218- 222
Religa D, Styczynska M, Peplonska B, Gabryelewicz T, Pfeffer A, Chodakowska M, Luczywek E, Wasiak B, Stepien K, Golebiowski M, Winblad B, Barcikowska M. Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment. Dement Geriatr Cogn Disord 2003; 16(2): 64-70
Kim J, Park MH, Kim E, Han C, Jo SA, Jo I. Plasma homocysteine is associated with the risk of mild cognitive impairment in an elderly Korean population. J Nutr 2007; 137(9): 2093-2097
Gortz P, Hoinkes A, Fleischer W, Otto F, Schwahn B, Wendel U, Siebler M. Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci 2004; 218(1-2): 109-114
Ganji V, Kafai MR. Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamins B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population. Am J Clin Nutr 2004; 80(6): 1500-1507
Brussaard JH, Lowik MR, van den Berg H, Brants HA, Goldbohm RA. Folate intake and status among adults in the Netherlands. Eur J Clin Nutr 1997; 51 Suppl 3: S46-S50
Planells E, Sanchez C, Montellano MA, Mataix J, Llopis J. Vitamins B6 and B12 and folate status in an adult Mediterranean population. Eur J Clin Nutr 2003; 57(6): 777-785
Hatzis CM, Bertsias GK, Linardakis M, Scott JM, Kafatos AG. Dietary and other lifestyle correlates of serum folate concentrations in a healthy adult population in Crete, Greece: a cross-sectional study. Nutr J 2006; 5: 5
Salerno-Kennedy R, Cashman KD. Relationship between dementia and nutrition-related factors and disorders: an overview. Int J Vitam Nutr Res 2005; 75(2): 83-95
Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003; 26(3): 137-146
Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, Thal LJ; Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 2008; 300(15): 1774-1783
Requejo AM, Ortega RM, Robles F, Navia B, Faci M, Aparicio A. Influence of nutrition on cognitive function in a group of elderly, independently living people. Eur J Clin Nutr 2003; 57 Suppl 1: S54-S57
Pepersack T, Garbusinski J, Robberecht J, Beyer I, Willems D, Fuss M. Clinical relevance of thiamine status amongst hospitalized elderly patients. Gerontology 1999; 45(2): 96-101
Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000; 54(6): 1265-1272
Drew KL, Toien O, Rivera PM, Smith MA, Perry G, Rice ME. Role of the antioxidant ascorbate in hibernation and warming from hibernation. Comp Biochem Physiol C Toxicol Pharmacol 2002; 133(4): 483-492
Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002; 287(24): 3223- 3229
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