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NTIS 바로가기Ocean and polar research, v.33 no.2, 2011년, pp.159 - 169
이준혁 (극지연구소 극지생명과학연구부) , 이성구 (극지연구소 극지생명과학연구부) , 김학준 (극지연구소 극지생명과학연구부)
Antifreeze proteins (AFPs) have ice binding affinity, depress freezing temperature and inhibit ice recystallization which protect cellular membranes in polar organisms. Recent structural studies of antifreeze proteins have significantly expanded our understanding of the structure-function relationsh...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
Type I AFP는 어디에서 처음 발견되었나? | Type I AFP는 winter flounder 혹은 shorthorn sculpin 같은 물고기의 혈장과 피부세포에서 처음 발견되어졌다. 그 중에서 winter flounder에 존재하는 HPLC6 AFP의 고해상도 삼차 구조가 AFP 중에서 가장 먼저 밝혀져 연구가 많이 되어져 왔다(Sicheri and Yang 1995). | |
AFP의 농도에 비례하여 어는점을 낮추지 않는 특성에 따른 장점은? | AFP의 또 다른 특징은 자동차에 사용되는 일반 부동액과는 달리 농도에 비례하여 어는점을 낮추지는 않는다. 따라서 AFP는 아주 낮은 농도에서 효과적으로 어는 점을 낮출 수 있고 이로 인해 생체 내에서 동결 과정 중에 발생하는 삼투압에 의한 손실을 최소화 할 수 있다(Jia and Davies 2002). | |
Type IV LS-12 AFP가 가지는 apolipoprotein A-I 단백질의 역할은? | 2008). apolipoprotein A-I 단백질은 지질과 결합하여 지질의 혈액 내에서의 용해도를 증가시키고 같이 결합되어져서 지질을 간 혹은 다른 기관으로 수송하는 역할을 한다. apolipoprotein A-I은 지질과 결합하지 않았을 때와 지질과 결합했을 때의 구조가 다르다고 알려져 있다. |
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Yamashita Y, Miura R, Takemoto Y, Tsuda S, Kawahara H, Obata H (2003) Type II antifreeze protein from a midlatitude freshwater fish, Japanese smelt (Hypomesus nipponensis). Biosci Biotechnol Biochem 67:461-466
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