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NTIS 바로가기동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, v.25 no.3, 2011년, pp.445 - 450
이숭인 (원광대학교 한의과대학 한방생리학교실) , 권강범 (원광대학교 한의과대학 한방생리학교실) , 한종현 (원광대학교 한의과대학 약리학교실) , 류도곤 (원광대학교 한의과대학 한방생리학교실)
In order to validate the use of Olibanum as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effect of water-soluble extract of Olibanum (EO) on the expression of pro-inflammatory vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cell...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
乳香이란 무엇인가? | 乳香(Olibanum)은 橄欖科(감람나무과 ; Burseraceae)에 속한 矮小灌木인 乳香나무 및 同屬 近緣植物의 膠狀樹脂로 性味는 辛. 苦, 溫 無毒하고 心. | |
乳香은 어떠한 병증을 치료하는가? | 消腫. 生肌 등의 효능이 있어 痛經, 經閉, 胃脘痛,風濕痺痛, 腸癰, 瘡癰久潰不斂 등의 병증을 치료하는 것으로 알려져 있다1). 실험적으로 乳香은 면역조절효과2,3), 세포고사 유도효과4,5) 등 다양한 효능이 있는 것6-9)으로 보고되고 있다. | |
VCAM-1 및 ICAM-1가 유도하는 것은 무엇인가? | 대식세포, 혈관 평활근세포, T-림프구, B-림프구 등의 여러 세포들과 여기에서 분비되는 TNF-α (tumor necrosis factor-alpha), interleukin 등의 여러 cytokine과 성장인자 및 화학주성인자들이 복합적으로 혈관에서의 염증발생에 관여하는 것으로 보이며 특히, TNF-α는 혈관 내피세포를 자극하여 IL-8(interleukin-8) 및 MCP-1 (monocyte chemoattractant protein-1)과 같은 chemokine을 생성시키고 세포 표면에 VCAM-1 및 ICAM-1과 같은 세포부착분자의 발현을 유도하여 초기 혈관 염증반응을 매개한다. 이러한 ICAM-1 및 VCAM-1은 혈관 내피세포에 면역세포들이 부착할 수 있도록 유도한다. |
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