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NTIS 바로가기생명과학회지 = Journal of life science, v.21 no.7 = no.135, 2011년, pp.1046 - 1051
김강미 (부산대학교 의학전문대학원 미생물학 및 면역학교실) , 이상권 (양산부산대학교병원 심혈관센터) , 박영철 (부산대학교 의학전문대학원 미생물학 및 면역학교실)
Diallyl disulfide (DADS), the most prevalent oil-soluble organosulfur compound in garlic, is known to have diverse biological activities, including anticarcinogenic, antiatherosclerotic, antiinflammatory, and antioxidant actions. In this study, we investigated the effect of DADS on the expression of...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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Heme oxygenase-1은 무엇을 산물로 방출하는가? | Heme oxygenase-1 (HO-1)은 일반적으로 heme을 대사시키는 효소로 잘 알려져 있으며, biliverdin, carbon monoxide 및 ferrous iron을 산물로 방출한다. Biliverdin은 biliverdin reductase에 의해 강력한 항산화 인자로 알려져 있는 bilirubin 으로 뒤이어 전환된다[25]. | |
Dially disulfide란 무엇인가? | Dially disulfide (DADS)는 마늘의 주요한 유기 황화합물 성분으로서 다양한 약리 작용을 나타낸다. 최근 DADS가 항염증과 항동맥경화 작용뿐만 아니라 암세포의 증식을 억제하고 사멸을 유도한다는 보고가 이어지고 있고, 이에 관련된 연구가 활발히 진행되고 있는 실정이다. | |
Heme oxygenase-1의 합성은 어떻게 유도되는가? | Biliverdin은 biliverdin reductase에 의해 강력한 항산화 인자로 알려져 있는 bilirubin 으로 뒤이어 전환된다[25]. HO-1은 저산소증[16], metal ions[24] 및 염증성 cytokines 등과 같은 산화적 스트레스(oxidative stress) 환경을 유도하는 자극[6,14]에 의해 합성이 유도된다. HO-1은 산화적 스트레스에 대항하여 세포 내 redox (reduction-oxidation) 균형을 유지하는 항산화 인자로서 크게 기여한다. |
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