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NTIS 바로가기Development & reproduction = 발생과 생식, v.15 no.2, 2011년, pp.179 - 185
허현진 (상명대학교 그린생명과학과) , 이성호 (상명대학교 그린생명과학과)
Some phytoestrogens in soy and red wine, for example, might have beneficiary rather than adverse effects. In particular, dietary soy intake seems to be highly correlated with protection of breast cancer, osteoporosis and cardiovascular disorders. However, questions persist on the potential adverse e...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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콩류 섭취는 어떤 질환의 예방에 도움이 되는가? | 반면, 콩이나 적포도주의 식물성 에스트로겐(phytoestrogen)의 경우 EDC로 분류되지만, 건강에 긍정적인 효과를 갖는 것으로 보인다(Whitsett & Lamartiniere, 2005). 이들 가운데 특히 콩류 섭취는 유방암이나 골다공증, 그리고 심혈관계 질환 예방과 높은 상관관계가 있는 것으로 보인다(Goldwyn et al., 2000). | |
콩류의 주성분인 genistein을 사춘기 전의 암컷 흰쥐에게 경구 투여했을 때, 그 결과는 어떠했는가? | 선행 연구에서 본 연구자들은 사춘기 전에 GS를 경구 투여했을 때 암컷 흰쥐의 생식계가 활성화되어 조기 사춘기가 유도되고, 암컷 성체에 GS를 뇌실내(intracerebroventricular, ICV) 미세주입했을 때 kisspeptin-GnRH 뉴런 회로의 활성화가 일어남을 관찰하였다(Lee & Lee, 2006a; Lee & Lee, 2010). 이러한 결과들은 GS 노출에 따라 암컷 사춘기 개시 시점이 변화할 수 있으며, 적어도 시상하부가 GS의 표적조직이 될 수 있고, GS의 에스트로겐성 효과가 전형적인 장기적인 것이 아닌 단기적으로 나타날 수 있음을 보여준 것이다. | |
내분비계 장애물질에 노출되면 어떤 증상이 야기되는가? | 지난 수십 년 간 연구자들은 다수의 환경 물질들이 인간과 야생동물들의 정상 내분비 기능을 교란할 수 있음을 발견하였는데, 이러한 내분비계 장애물질(endocrine disrupting chemical, EDC)들에 노출되면 흔히 발생 및 생식독성이 야기된다(Hoyer, 2001; Lyons, 2006). 반면, 콩이나 적포도주의 식물성 에스트로겐(phytoestrogen)의 경우 EDC로 분류되지만, 건강에 긍정적인 효과를 갖는 것으로 보인다(Whitsett & Lamartiniere, 2005). |
Bateman HL, Patisaul HB (2008) Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology 29:988-997.
Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159.
Chrzan BG, Bradford PG (2007) Phytoestrogens activate estrogen receptor beta1 and estrogenic responses in human breast and bone cancer cell lines. Mol Nutr Food Res 51:171-177.
Fitzpatrick LA (2003) Soy isoflavones: hope or hype? Maturitas 44(supp l1):S21-S29.
Gingerich S, Krukoff TL (2005) Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures. Endocrinology 146:2933-2941.
Goldwyn S, Lazinsky A, Wei H (2000) Promotion of health by soy isoflavones: efficacy, benefit and safety concerns. Drug Metabol Drug Interact 17:261-289.
Hoyer PB (2001) Reproductive toxicology: current and future directions. Biochem Pharmacol 62:1557-1564.
Jefferson WN, Padilla-Banks E, Newbold RR (2007) Disruption of the developing female reproductive system by phytoestrogens: genistein as an example. Mol Nutr Food Res 51:832-844.
Johnson MS, Wolbers WB, Noble J, Fennell M, Mitchell R (1995) Effect of tyrosine kinase inhibitors on luteinizing hormone-releasing hormone (LHRH)-induced gonadotropin release from the anterior pituitary. Mol Cell Endocrinol 109:69-75.
Kasuya E, Nyberg CL, Mogi K, Terasawa E (1999) A role of gamma-amino butyric acid (GABA) and glutamate in control of puberty in female rhesus monkeys: effect of an antisense oligodeoxynucleotide for GAD67 messenger ribonucleic acid and MK801 on luteinizing hormonereleasing hormone release. Endocrinology 140:705-712.
Kouki T, Kishitake M, Okamoto M, Oosuka I, Takebe M, Yamanouchi K (2003) Effects of neonatal treatment with phytoestrogens, genistein and daidzein, on sex difference in female rat brain function: estrous cycle and lordosis. Horm Behav 44:140-145.
Lamartiniere CA, Zhang JX, Cotroneo MS (1998) Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. Am J Clin Nutr 68(suppl):1400S-1405S.
Lee K-Y, Lee S-H (2006a) Effect of genistein on the onset of puberty in female rats. Dev Reprod 10:55-61.
Lee K-Y, Lee S-H (2006b) Effects of endocrine disruptors on the expression of estrogen receptors in ovary and uterus from immature rats. Dev Reprod 10:255-261.
Levy JR, Faber KA, Ayyash L, Hughes CL Jr (1995) The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats. Proc Soc Exp Biol Med 208:60-66.
Lyons G (2006) Viewpoint: Policy requirements for protecting wildlife from endocrine disruptors. Environ Health Perspect 114 Suppl 1:142-146.
McCarty MF (2006) Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits. Med Hypotheses 66:1093-1114.
Messina M, Nagata C, Wu AH (2006) Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer 55:1-12.
Misztal T, Gorski K, Romanowicz K (2008) Differential endocrine response in rams to intracerebroventricular infusion of genistein. Acta Neurobiol Exp (Wars) 68:43-50.
Polkowska J, Ridderstrale Y, Wa?kowska M, Romanowicz K, Misztal T, Madej A (2004) Effects of intracerebroventricular infusion of genistein on gonadotrophin subunit mRNA and immunoreactivity of gonadotrophins and oestrogen receptor-alpha in the pituitary cells of the anoestrous ewe. J Chem Neuroanat 28:217-224.
Roa J, Garcia-Galiano D, Varela L, Sanchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, Lopez M, Gaytan F, Dieguez C, Pinilla L, Tena-Sempere M (2009) The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 150:5016-5026.
Takagi H, Shibutani M, Lee KY, Lee HC, Nishihara M, Uneyama C, Takigami S, Mitsumori K, Hirose M (2004) Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats. Reprod Toxicol 18:687-700.
Whitsett TG, Lamartiniere CA (2006) Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther 6:1699-1706.
Wojcik-Gładysz A, Romanowicz K, Misztal T, Polkowska J, Barcikowski B (2005) Effects of intracerebroventricular infusion of genistein on the secretory activity of the GnRH/LH axis in ovariectomized ewes. Anim Reprod Sci 86:221-235.
Wozniak AL, Bulayeva NN, Watson CS (2005) Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells. Environ Health Perspect 113:431-439.
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