최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기大韓韓醫學會誌 = Journal of Korean Oriental Medicine, v.33 no.3, 2012년, pp.160 - 183
김기배 (부산대학교 한의학전문대학원 임상의학부 한방내과) , 이형탁 (부산대학교 한의학전문대학원 임상의학부 한방내과) , 구경회 (부산대학교 한의학전문대학원 임상의학부 한방내과) , 홍진우 (부산대학교 한의학전문대학원 임상의학부 한방내과) , 조수인 (부산대학교 한의학전문대학원 약물의학부)
Objectives: Coptidis Rhizoma is one of the most popular and multi-purpose herbs in traditional medicine. The purpose of this study was to contribute to research and applications of Coptidis Rhizoma in clinic, by analyzing and reviewing international studies on its chemical compositions and pharmacol...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
황련은 무엇인가? | 황련(黃連, Coptis Radix)은 미나리아재비과(毛茛科: Ranunculaceae)에 속하는 多年生 草本인 黃連의 根莖으로, 가을에 채취하여 鬚根 및 진흙과 모래를 제거한 다음 건조시킨 것으로 활용한다.1) 黃連은 苦寒한 性味와 함께 심, 비, 위, 간, 담, 대장경에 작용하는 특징으로, 淸熱燥濕·瀉心除煩·瀉火解毒의 效能을 가지고 있다. | |
한의학에서 黃連은 어떤 치료에 활용되는가? | 1) 黃連은 苦寒한 性味와 함께 심, 비, 위, 간, 담, 대장경에 작용하는 특징으로, 淸熱燥濕·瀉心除煩·瀉火解毒의 效能을 가지고 있다.1) 이를 바탕으로, 濕熱肥滿, 嘔吐呑酸, 瀉痢, 黃疸, 高熱神昏, 心火亢盛, 心煩不寐, 血熱吐衄, 目赤, 牙痛, 消渴, 癰腫疔瘡 등 치료에 활용될 뿐만 아니라 濕疹·濕瘡·耳道流膿 등과 같은 외과적 치료에도 활용되고 있다.1) 黃連에는 주로 berberine, copti- sine, epiberberine, palmatine, jateorrhizine, magnoflorine, worenine 등의 성분이 포함되어 있다. | |
黃連에는 어떤 성분들이 포함되어 있는가? | 1) 이를 바탕으로, 濕熱肥滿, 嘔吐呑酸, 瀉痢, 黃疸, 高熱神昏, 心火亢盛, 心煩不寐, 血熱吐衄, 目赤, 牙痛, 消渴, 癰腫疔瘡 등 치료에 활용될 뿐만 아니라 濕疹·濕瘡·耳道流膿 등과 같은 외과적 치료에도 활용되고 있다.1) 黃連에는 주로 berberine, copti- sine, epiberberine, palmatine, jateorrhizine, magnoflorine, worenine 등의 성분이 포함되어 있다. 黃連에 관련된 연구는 이러한 성분들의 개별 효과 및 약리기전에 대해 활발히 진행되어지고 있다. |
전국한의과대학 공통교재편찬위원회. 본초학. 서울:영림사. 2008: 218-20.
Shin HS, You HK, Song KB. Effects of Rhizorna Coptidis on Cellular Activity and IL-6 Production of LPS-treated Periodontal Ligarnent Cells. Journal of Wonkwang dental Research institute. 1997;7(1):177-91.
山原條二. 황련 및 그의 함유성분의 중추억제 작용. Berberine형 알칼로이드의 행동약리학적 연구(제1판), 日藥理誌. 1976:899-908.
Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol. 2009;126(1):5-17.
Liu F, Ng T. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci. 2000;66(8):725-35.
Ye X, Feng Y, Tong Y, Ng K, Tsao S, Lau G et al. Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride- induced acute liver hepatotoxicity in rats. J Ethnopharmacol. 2009;124(1):130-6.
Hong Y, Hui S, Chan T, Hou J. Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats. Am J Chin Med. 2002;30(4):589-99.
Lee C, Lee J, Seok J, Hur G, Park Y, Seol I et al. Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. Planta Med. 2003 ;69(6):523-6.
Li B, Shang J, Zhou Q. [Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers]. Chin J Integr Med. 2005;11(3):217-21.
Lu J, Liu Y, Li M, Li B, Xu Y. [Protective effects and its mechanisms of total alkaloids from rhizoma Coptis chinensis on Helicobacter pylori LPS induced gastric lesion in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32(13):1333-6.
Park E, Rhee H, Jung H, Ju S, Lee Y, Lee S et al. Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother Res. 2007;21(8): 746-50.
Lee YA, Hong SJ, Lee SH, Park EK, Kim KS, Han CS et al. Original Articles : Anti-inflammatory Effects of the Coptis chinensis Extract. The Journal of Kyung Hee University Medical Center. 2007;23(1):21-9.
Cuellar M, Giner R, Recio M, Manez S, Rios J. Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders. Fitoterapia. 2001 Mar;72(3):221-9
Zhang Q, Piao XL, Piao XS, Lu T, Wang D, Kim SW. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. 2011;49(1):61-9.
Cho J, Kim A, Park M. Lignans from the rhizomes of Coptis japonica differentially act as anti- inflammatory principles. Planta Med. 2001;67 (4):312-6.
Cho J, Park J, Yoo E, Yoshikawa K, Baik K, Lee J, et al. Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide- stimulated RAW264.7 cells. Arch Pharm Res. 1998;21(1):12-6.
Cho J, Baik K, Yoo E, Yoshikawa K, Park M. In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. J Nat Prod. 2000 ;63(9):1205-9.
Lee G, Ha J, Min K, Nakagawa H, Tsurufuji S, Chang I, et al. Inhibitory effects of Oriental herbal medicines on IL-8 induction in lipopolysaccharide- activated rat macrophages. Planta Med. 1995;61(1):26-30.
Sin KH, An DK, Woo ER, Park HK, Lee JS, Yun WS. A study on extraction efficiency of berberine in Coptidis rhizoma. J. Kor. Analyical Sci. 1997;10(2):83-91.
Jang GH, An BY, Oh SH, Choi DS, Kwon YJ. Anticariogenic effects of Coptis chinensis Franch Extract. Kor. J. Food Sci. Technol. 2000;32(6): 1396-1402.
Chen Q, Chen N, Wang S. [Experimental study of R plasmid eliminating action of Coptis chinensis on E. coli]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996;16(1):37-8.
Yang L, Singh M, Yap E, Ng G, Xu H, Sim K. In vitro response of Blastocystis hominis against traditional Chinese medicine. J Ethnopharmacol. 1996;55(1):35-42.
Park H, Kim M, Jeon B, Kim T, Kim Y, Ahnn J, et al. Antimalarial activity of herbal extracts used in traditional medicine in Korea. Biol Pharm Bull. 2003 ;26(11):1623-4.
Doh ES. Antifungal activity of Anemarrhena asphodeloides, Phellodendron amurense and Coptis japonica Extracts against Welsh-onion Alternaria Leaf Spot(Alternaria porri). JOURNAL OF NATURAL SCIENCE. 1998;7(1):29-39.
Kim KJ, Jeon BH, Woo WH. Effects of Coptidis Rhizoma on the growth and pH of Streptococcus Mutans 10449. Korean Journal of Oriental Medical Pathology. 1993;8(1):111-8.
Schinella G, Tournier H, Prieto J, Rios J, Buschiazzo H, Zaidenberg A. Inhibition of Trypanosoma cruzi growth by medical plant extracts. Fitoterapia. 2002;73(7-8):569 -75.
Kim YH, Lee JJ, Sung YC, Leem AH, Song MK. Inhibition of HIV-1 Replication by Extract of Coptis chinensis. Biomolecules & Therapeutics. 1995;3(2):111-5.
Doh ES. Antifungal Activity or Coptis japonica Root-stem Extract and Identification of Antifungal Substances. Korean Journal of Plant Resources. 1999;12(4):260-8.
Paik SB, Chung I. Effect of Medicinal Plant Extracts on Apple Storage Diseases. Plant Pathology Journal. 1997;13(1):57-62.
Yu H, Kim K, Cha J, Kim H, Lee Y, Choi N, et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005;8(4):454-61.
Chae S, Jeong I, Choi D, Oh J, Ahn Y. Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria. J Agric Food Chem. 1999;47(3): 934-8.
Jia F, Zou G, Fan J, Yuan Z. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010;155(8):1325-9.
Yan D, Jin C, Xiao X, Dong X. Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. J Biochem Biophys Methods. 2008 ;70 (6):845-9.
Choe HS, Kim IC, Lee JS, Jo ML, Seo CH, Park SI. Antibacterial Activities of Hot-water and Ethyl Alcohol Extracts of Medicinal Herbs on Fish Pathogenic Bacteria. The Korean Society of Fish Pathology. 2004;17(1):39-55.
Auyeung K, Ko J. Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. Int J Mol Med. 2009;24(4):571-7.
Lin C, Ng L, Hsu F, Shieh D, Chiang L. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol. 2004; 31(1-2):65-9.
Ma C, Shen S, Huang D, Chang H, Wu J. Growth inhibition and induction of apoptosis in U937 cells by Coptis chinensis extract. J Food Sci. 2008;73(6):127-33.
Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, Fan W, et al. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci. 2004;74(20) :2467-78.
Kang J, Liu J, Wang J, He C, Li F. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon- beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005;26(11):1934-9.
Li X, Motwani M, Tong W, Bornmann W, Schwartz G. Huanglian, A chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells. Mol Pharmacol. 2000 Dec;58(6):1287-93.
Lee MJ, Park JW, Kim YJ, Oh JS, Kim JK, Choi DY. Nitrite Scavenging Activity of Water- Extract from Scutellaria baicalensis Georgi. and Coptis chinensis Franch.. J Korean Oriental Medical Pathology. 2000;14(2):108-17.
Park H, Kim Y, Leem K, Park S, Seo J, Kim H, et al. Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells. Phytother Res. 2005;19(3):189-92.
Chi C, Chang Y, Chao T, Chiang S, P'eng F, Lui W, et al. Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. Life Sci. 1994;54(26):2099-107.
Jin L, Liao H, Zhang M, Liu Q, Wang Y. [Effect of berberine on the differentiation and apoptosis of K562 cell line]. Zhong Yao Cai. 2009;32(3): 384-8.
Kim J, Yu J, Ko E, Lee K, Song A, Park S, et al. The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. Phytomedicine. 2010;17(6):436-40.
Liang K, Yin S, Ting C, Lin S, Hsueh C, Chen C, et al. Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells. Eur J Pharmacol. 2008 ;590(1-3):343-54.
Lin H, Liu T, Lui W, Chi C. Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. Cancer. 1999;85(9) :1937-42.
Liang K, Ting C, Yin S, Chen Y, Lin S, Liao J, et al. Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol. 2006;71(6):806-17.
Tanabe H, Suzuki H, Mizukami H, Inoue M. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochem Pharmacol. 2005;70(8):1176-84.
Wang X, Xu L, Peng J, Liu K, Zhang L, Zhang Y. In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa. Planta Med. 200;75(11):1215-20.
Dong L, Shi H, Ji G, Wu D. Effects of Coptis chinensis and Evodia rutaecarpa water extract on DMH-induced precancerous lesion of colon. Zhongguo Zhong Yao Za Zhi. 2010;35(9):1185-8.
Kobayashi Y, Yamashita Y, Fujii N, Takaboshi K, Kawakami T, Kawamura M, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995;61(5):414-8.
Schinella G, Tournier H, Prieto J, Mordujovich de Buschiazzo P, Rios J. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 2002;70(9):1023-33.
Song L, Chen K, Zhu J. The effect of Coptis chinensis on lipid peroxidation and antioxidases activity in rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 ;12(7) :421-3.
Kim YJ, Lee MJ, Park JW, Kim JK, Choi DY, Kim CH. Antioxidant Activity of Water-extract from Coptis chinensis Franch.. Korean J. Life Science. 2000;10(3):241-6.
An BJ, Lee JT, Lee CE, Kim JH, Son JH, Kwak JH, et al. A Study on physiological activities of Coptidis Rhizoma and application for cosmetic ingredients. J Korean Herbology. 2005;20(3):83-92
Lau C, Yao X, Chen Z, Ko W, Huang Y. Cardiovascular actions of berberine. Cardiovasc Drug Rev. 2001;19(3):234-44.
Liang K, Ting C, Yin S, Chen Y, Lin S, Liao J, et al. Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol. 2006;71(6): 806-17.
Wu M, Wang J, Liu LT. Advance of studies on anti-atherosclerosis mechanism of berberine. Chin J Integr Med. 2010;16(2):188-92.
Lin N, Gao X, Li J, Zhu J. [Influence of huanglian and berberine on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats]. Zhongguo Zhong Yao Za Zhi. 1998;23(9):562-4, back cover.
Abidi P, Chen W, Kraemer F, Li H, Liu J. The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. J Lipid Res. 2006;47(10):2134-47.
Yuan L, Tu D, Ye X, Wu J. Hypoglycemic and hypocholesterolemic effects of Coptis chinensis franch inflorescence. Plant Foods Hum Nutr. 2006;61(3):139-44.
Yuan Z, Zhu L, Pang H, Shan Z, Wang S, Gao Y, et al. [Protective action of effective components of Huanglian Jiedu decoction on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells]. Zhongguo Zhong Yao Za Zhi. 2007;32(3):249-52.
Yotsumoto H, Yanagita T, Yamamoto K, Ogawa Y, Cha J, Mori Y. Inhibitory effects of oren-gedoku- to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. Planta Med. 1997;63(2):141-5.
Sekiya N, Kogure T, Kita T, Kasahara Y, Sakakibara I, Goto H, et al. Reduction of plasma triglyceride level and enhancement of plasma albumin concentration by Oren-gedoku-to administration. Phytomedicine. 2002;9(5):455-60.
Lin N, Gao X, Li J, Zhu J. [Influence of huanglian used in combination with huangqin and gancao on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats]. Zhongguo Zhong Yao Za Zhi. 1998;23(10):630-2, inside back cover.
Tan Y, Kamal MA, Wang ZZ, Xiao W, Seale JP, Qu X. Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome. Clin Sci (Lond). 2011;120(7): 297-305.
Feng Y, Siu KY, Ye X, Wang N, Yuen MF, Leung CH, et al. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med. 2010 Sep 18;5:33.
Hsiang C, Wu S, Cheng S, Ho T. Acetaldehydeinduced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci. 2005;12(5): 791-801.
Lee WC, Kim JK, Kang JW, Oh WY, Jung JY, Kim YS, et al. Palmatine attenuates D-galactosamine/ lipopolysaccharide-induced fulminant hepatic failure in mice. Food Chem Toxicol. 2010;48(1):222-8.
Yoon SH, Ha H, Seo MJ. Effect of Coptis Rhizoma on Benzo (a) pyrene-Induced Hepatotoxicity. KOR. J. Environ. Toxicol. 1993;8(1):31-35.
Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate. 1993;63(4):201-8.
Affuso F, Mercurio V, Fazio V, Fazio S. Cardiovascular and metabolic effects of Berberine. World J Cardiol. 2010;2(4):71-7.
Hui H, Tang G, Go V. Hypoglycemic herbs and their action mechanisms. Chin Med. 2009;4:11.
Ma X, Egawa T, Kimura H, Karaike K, Masuda S, Iwanaka N, et al. Berberine-induced activation of 5'-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles. Metabolism. 2010;59(11):1619-27.
Lee H. Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. J Agric Food Chem. 2002;50(24):7013-6.
Hsieh M, Peng W, Wu C, Wang W. The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats. Phytother Res. 2000;14(5):375-7.
Li B, Liu H, Pan Y, Jiang Q, Shang J, Wan X, et al. [Protective effects of total alkaloids from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats]. Zhongguo Zhong Yao Za Zhi. 2006;31(1):51-4.
Yoo J, Yang E, Cho J, Lee J, Jeong S, Nah S, et al. Inhibitory effects of berberine against morphine- induced locomotor sensitization and analgesic tolerance in mice. Neuroscience. 2006; 142(4):953-61.
Yoo HG. Effect of Rhizoma coptidis and Centella asiatica extracts on human gingival fibroblasts. Journal of Periodontal & Implant Science. 1996;26(3):681-8.
Chuang C, Chang P, Hsieh W, Tsai Y, Lin S, Chen P. Chinese herbal medicine use in Taiwan during pregnancy and the postpartum period: a population-based cohort study. Int J Nurs Stud. 2009;46(6):787-95.
Li Y. A clinical study on haunglian fire-purging mixture in treatment of 46 cases of primary hypertension. J Tradit Chin Med. 2005;25(1):29-33.
Shin HK, Choi WH, Li ST, Choi KS, Kim JB. Isolation and Identification of Spore Germination Inhibitory Substance from Coptis chinensis Franch and its Inhibitory Effect on Spore Germination. Korean J. OF FOOD SCI. RESOUR. 1994;14(1):21-7.
Namba T, Sekiya K, Toshinal A, Kadota S, Hatanaka T, Katayama K, et al. [Study on baths with crude drug II.: the effects of coptidis rhizoma extracts as skin permeation enhancer]. Yakugaku Zasshi. 1995;115(8):618-25.
Park I, Lee H, Lee S, Park J, Ahn Y. Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae). J Econ Entomol. 2000;93(2) :331-5.
Liang Y, Minami H, Sato F. Isolation of herbicide- resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells. Biosci Biotechnol Biochem. 2008 ;72(11):3059-62.
Park WP, Cho SH. Treatment of Korean Medical Herb Extracts Affects the Quality Characterisics of Vegetables. Journal of the Korean Society of Post-Harvest Science & Technology of Agricultural Products. 1999;6(3):276-80.
An BJ, Lee JT, Lee CE, Kim JH, Son JH, Kwak JH, et al. A Study on Physiological Activities of Coptidis Rhizoma and Application for Cosmetic Ingredients. Korean journal of herbology. 2005;20(3):83-92.
Ma B, Ma Y, Shi R, Wang T, Zhang N, Wang C, et al. Identification of the toxic constituents in Rhizoma Coptidis. J Ethnopharmacol. 2010;128(2):357-64.
Chuang C, Doyle P, Wang J, Chang P, Lai J, Chen P. Herbal medicines used during the first trimester and major congenital malformations: an analysis of data from a pregnancy cohort study. Drug Saf. 2006;29(6):537-48.
Lee BB, Hahm DH, Lee HJ, Shim IS. Effect of Coptidis Rhizoma on repeated cocaine - induced behavioral sensitization and Fos - like immunoreactivity in the brain of the rats. Korean J. Biological and Physiological Psychology. 2001; 13(1):57-69.
성상현, 박진호. 천연물 의약품의 현황과 전망. 서울:한국보건산업진흥원. 2006;2:14-23.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.