[논문]사염화탄소 투여로 간독성을 유발한 쥐에서 생강열수추출물의 간보호 효과

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사염화탄소 투여로 간독성을 유발한 쥐에서 생강열수추출물의 간보호 효과
The Protective Effect of Ginger Aqueous Extracts on $CCl_4$-induced Hepatic Damage in Mice 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.29 no.6, 2012년, pp.441 - 446

초록
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이 실험의 목적은 사염화탄소 투여로 간독성이 유발된 마우스에서 생강열수추출물의 간보호 작용을 알아보는 것이다. 생강투여군과 실리마린투여군은 사염화탄소(4 ml/kg)를 투여하기 전 3일동안 생강(500 mg/kg), 실리마린(50 mg/kg)을 경구 투여하였다. 혈청화학적 검사에서 생강투여군은 대조군과 비교하여 AST, ALT가 유의적 감소(p < 0.05)가 인정되었으며, 조직병리학적 평가에서도 생강투여군은 대조군에 비해 간변성 및 신장변성이 유의적 감소(p < 0.05)가 인정되었다. 이 결과 생강열수추출물의 경구투여가 사염화탄소로 유발된 간독성 마우스에서 간보호 효과가 있다고 생각된다.

Abstract ▼ AI-Helper

The purpose of present study is to observe the hepato-protective effect of ginger aqueous extracts on carbon tetrachloride($CCl_4$)-induced mouse. Ginger groups received ginger aqueous extracts (500 mg/kg) orally for 3 days and given a single dose of $CCl_4$ (4 mL/kg). Silymarin group was treated with silymarin (50 mg/kg) orally for 3 days and then aministration of $CCl_4$ (4 mL/kg). Control group was only administered $CCl_4$ (4 mL/kg). In the ginger groups, the AST, ALT levels were significantly (p < 0.05) decreased compared to the control groups. Histopathological evaluation, hepatic parenchyma and kidney parenchyma of ginger groups were significantly (p < 0.05) decreased compared to control group. The results obtained in this study suggest that ginger aqueous extracts are able to protect the liver $CCl_4$-induced injury.

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대상 데이터

One hundred adult male ICR mice were obtained from Orient Bio (Korea) and allowed to acclimatize 7 days prior to initiating this study. The mice (7 wks old, 37.
The mice (7 wks old, 37.5 ± 2.26 g) were housed in polypropylene cage (five mice per cage) and maintained in a temperature-controlled room (24 ± 1℃) with 12:12h light:dark cycles.

데이터처리

Statistical analysis was performed with Student’s t-test and an ANOVA using SPSS for Windows (version 6.1.3; SPSS Inc., USA).

성능/효과

In this study, the protective effects of ginger aqueous extracts on CCl₄-induced liver damage in mice were evaluated and compared to those of silymarin.
Sections were then cut (3~4 µm) and stained with hematoxylin and eosin (H&E), and after that the histopathological profiles of each sample were observed under a light microscope (Nikkon, Japan). The percentages of degenerative regions in hepatic parenchyma (%/mm²), the numbers of degenerative hepatocytes (numbers/1000 hepatocytes), percentages of degenerative regions in kidney parenchyma (%/mm²), numbers of degenerative glomerulus (numbers/100 glomeruli) and numbers of abnormal kidney tubules (numbers/1000 tubules) were observed by histomorphometry, respectively.
Ajith et al reported that the mice were administered acetaminophen to induce liver damage, then prescribed ginger extracts. The results showed that AST, ALT, and ALP activity rates significantly decreased compared to those of the control group (3,13). In the present study, AST and ALT levels in the control groups were significantly (p < 0.
These CCl4-related kidney damages were confirmed with histomorphometry as percentages of degenerative regions in kidney parenchyma, numbers of degenerateve glomerulus and numbers of abnormal kidney tubules were significantly (p < 0.01) increased as compared with normal group, respectively.

참고문헌 (20)

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연합인증

사염화탄소 투여로 간독성을 유발한 쥐에서 생강열수추출물의 간보호 효과
The Protective Effect of Ginger Aqueous Extracts on $CCl_4$-induced Hepatic Damage in Mice 원문보기

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사염화탄소 투여로 간독성을 유발한 쥐에서 생강열수추출물의 간보호 효과 The Protective Effect of Ginger Aqueous Extracts on $CCl_4$-induced Hepatic Damage in Mice 원문보기

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사염화탄소 투여로 간독성을 유발한 쥐에서 생강열수추출물의 간보호 효과
The Protective Effect of Ginger Aqueous Extracts on $CCl_4$-induced Hepatic Damage in Mice 원문보기

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