Phan, Thi Anh Dao
(Faculty of Chemistry and Food, University of Technical Education Hochiminh City)
,
Nguyen, Xuan Hai
(Faculty of Chemistry, University of Science, National University Hochiminh City)
,
Nguyen, Trung Nhan
(Faculty of Chemistry, University of Science, National University Hochiminh City)
,
Tran, Le Quan
(Faculty of Chemistry, University of Science, National University Hochiminh City)
,
Nguyen, Thi Thanh Mai
(Faculty of Chemistry, University of Science, National University Hochiminh City)
Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from $10-100{\mu}g/mL$, 67 showed an inhibition rate over 50% at $100{\mu}g/mL$; 47 had greater than 50% inhibition at $50{\mu}g/mL$; 17 s...
Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from $10-100{\mu}g/mL$, 67 showed an inhibition rate over 50% at $100{\mu}g/mL$; 47 had greater than 50% inhibition at $50{\mu}g/mL$; 17 showed over 50% inhibition at $25{\mu}g/mL$. 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at $10{\mu}g/mL$ were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with $IC_{50}$ values from 30.6 to $158.9{\mu}g/mL$. Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with $IC_{50}$ values from 6.5 to $23.6{\mu}M$.
Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from $10-100{\mu}g/mL$, 67 showed an inhibition rate over 50% at $100{\mu}g/mL$; 47 had greater than 50% inhibition at $50{\mu}g/mL$; 17 showed over 50% inhibition at $25{\mu}g/mL$. 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at $10{\mu}g/mL$ were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with $IC_{50}$ values from 30.6 to $158.9{\mu}g/mL$. Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with $IC_{50}$ values from 6.5 to $23.6{\mu}M$.
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제안 방법
Extraction and isolation of the active compounds from the stem of Spatholobus parviflorus − In this study, S. parviflorus was selected to isolate and identify its active constituents.
대상 데이터
Plant materials − Vietnamese medicinal plants used in this study were collected at the Seven-Mountain area in An Giang province on August 2009 (Table 1).
Plant materials − Vietnamese medicinal plants used in this study were collected at the Seven-Mountain area in An Giang province on August 2009 (Table 1). The plants were identified by Dr. Hoang Viet, Faculty of Biology, University of Science, National University Ho Chi Minh City. The voucher samples are preserved with analytical number from 1001 to 1090 at Department of Analytical Chemistry, Faculty of Chemistry, University of Science, National University-Ho Chi Minh City.
성능/효과
Five extracts from the flower of the female flower of B. flabellifer and the stem of C. latifolium, E. ribes and S. parviflorus, and T. erubescens, showed strong activity. Although these plants are used in Vietnamese folk medicine to treat of inflammatory diseases this is the first report on their DPPH inhibitory and lipid peroxidation inhibitory activity.
후속연구
In conclusion, we have carried out a systematic investigation of Vietnamese medicinal plants for DPPH inhibitory activity and lipid peroxidation inhibition. The results indicate a number of medicinal plants that may be useful for the treatment of diseases relating free radical damages, and provide the basis for further investigation on these medicinal plant species to isolate active constituents and drug development. Specifically, this is the first scientific report on antioxidant activity of the female flower of B.
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