$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

들쭉 추출물의 노인성 황반변성증 예방 효과
Protective Effect of Vaccinium uliginosum L. Extract on Age-related Macular Degeneration 원문보기

약학회지 = Yakhak hoeji, v.56 no.5, 2012년, pp.314 - 319  

김선미 (경희대학교 약학대학) ,  김혜주 (동아제약(주)연구본부) ,  손미원 (동아제약(주)연구본부) ,  정세영 (경희대학교 약학대학)

Abstract AI-Helper 아이콘AI-Helper

Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among the elderly. In this study, extract of Vaccinium uliginosum L. that has potent antioxidant activity was evaluated as effective preventive supplement for AMD using AMD animal model induced by high fat diet ...

주제어

참고문헌 (35)

  1. Michikawa, T., Ishida, S., Nishiwaki, Y., Kikuchi, Y., Tsuboi, T., Hosoda, K., Ishigami, A., Iwasawa, S., Nakano, M. and Takebayashi, T. : Serum antioxidants and age-related macular degeneration among older Japanese. Asia Pac. J. Clin. Nutr. 18, 1 (2009). 

  2. Klein, R., Klein, B. E. and Linton, K. L. : Prevalence of agerelated maculopathy. The Beaver Dam Eye Study. Ophthalmology 99, 933 (1992). 

  3. Friedman, D. S., Katz, J., Bressler, N. M., Rahmani, B. and Tielsch, J. M. : Racial differences in the prevalence of agerelated macular degeneration: the Baltimore Eye Survey. Ophthalmology 106, 1049 (1999). 

  4. VanNewkirk, M. R., Nanjan, M. B., Wang, J. J., Mitchell, P., Taylor, H. R. and McCarty, C. A. : The prevalence of agerelated maculopathy: the visual impairment project. Ophthalmology 107, 1593 (2000). 

  5. Delcourt, C., Diaz, J. L., Ponton-Sanchez, A. and Papoz, L. : Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liees a l'Age. Arch. Ophthalmol. 116, 1031 (1998). 

  6. Khan, J. C., Thurlby, D. A., Shahid, H., Clayton, D. G., Yates, J. R., Bradley, M., Moore, A. T. and Bird, A. C. : Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br. J. Ophthalmol. 90, 75 (2006). 

  7. Klein, R., Klein, B. E., Jensen, S. C., Mares-Perlman, J. A., Cruickshanks, K. J. and Palta, M. : Age-related maculopathy in a multiracial United States population: the National Health and Nutrition Examination Survey III. Ophthalmology 106, 1056 (1999). 

  8. Chachat, A. P., Hyman, L., Leske, M. C., Connell, A. M. and Wu, S. Y. : Features of age-related macular degeneration in a black population. The Barbados Eye Study Group. Arch. Ophthalmol. 113, 728 (1995). 

  9. Haddad, S., Chen, C. A., Santangelo, S. L. and Seddon, J. M. : The genetics of age-related macular degeneration: a review of progress to date. Surv. Ophthalmol. 51, 316 (2006). 

  10. Scholl, H. P., Fleckenstein, M., Charbel Issa, P., Keilhauer, C., Holz, F. G. and Weber, B. H. : An update on the genetics of age-related macular degeneration. Mol. Vis. 13, 196 (2007). 

  11. Tomany, S. C., Wang, J. J., Van Leeuwen, R., Klein, R., Mitchell, P., Vingerling, J. R., Klein, B. E., Smith, W. and De Jong, P. T. : Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology 111, 1280 (2004). 

  12. Cho, E., Hung, S., Willett, W. C., Spiegelman, D., Rimm, E. B., Seddon, J. M., Colditz, G. A. and Hankinson, S. E. : Prospective study of dietary fat and the risk of age-related macular degeneration. Am. J. Clin. Nutr. 73, 209 (2001). 

  13. Okamoto, H., Umeda, S., Obazawa, M., Minami, M., Noda, T., Mizota, A., Honda, M., Tanaka, M., Koyama, R., Takagi, I., Sakamoto, Y., Saito, Y., Miyake, Y. and Iwata, T. : Complement factor H polymorphisms in Japanese population with agerelated macular degeneration. Mol. Vis. 12, 156 (2006). 

  14. Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J. Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., Bracken, M. B., Ferris, F. L., Ott, J., Barnstable, C. and Hoh, J. : Complement factor H polymorphism in agerelated macular degeneration. Science 308, 385 (2005). 

  15. Souied, E. H., Leveziel, N., Richard, F., Dragon-Durey, M. A., Coscas, G., Soubrane, G., Benlian, P. and Fremeaux-Bacchi, V. : Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Mol. Vis. 11, 1135 (2005). 

  16. Flood, V., Smith, W., Wang, J. J., Manzi, F., Webb, K. and Mitchell, P. : Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 109, 2272 (2002). 

  17. Van Leeuwen, R., Boekhoorn, S., Vingerling, J. R., Witteman, J. C., Klaver, C. C., Hofman, A. and de Jong, P. T. : Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 294, 3101 (2005). 

  18. Taylor, H. R., West, S., Munoz, B., Rosenthal, F. S., Bressler, S. B. and Bressler, N. M. : The long-term effects of visible light on the eye. Arch. Ophthalmol. 110, 99 (1992). 

  19. Klein, R., Peto, T., Bird, A. and Vannewkirk, M. R. : The epidemiology of age-related macular degeneration. Am. J. Ophthalmol. 137, 486 (2004). 

  20. Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T., Klaver, C. C., Klein, B. E. and Klein, R. : An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv. Ophthalmol. 39, 367 (1995). 

  21. Mitchell, P., Smith, W., Attebo, K. and Wang, J. J. : Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 102, 1450 (1995). 

  22. Thornton, J., Edwards, R., Mitchell, P., Harrison, R. A., Buchan, I. and Kelly, S. P. : Smoking and age-related macular degeneration: a review of association. Eye (Lond) 19, 935 (2005). 

  23. 보건복지부. 질병관리본부. 국민건강통계. 국민건강영양조사 제5기 1차년도 (2010) 

  24. Fliesler, S. J. and Anderson, R. E. : Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid. Res. 22, 79 (1983). 

  25. Ahmed, J., Braun, R. D., Dunn, R. Jr. and Linsenmeier, R. A. : Oxygen distribution in the macaque retina. Invest. Ophthalmol. Vis. Sci. 34, 516 (1993). 

  26. Sparrow, J. R. and Boulton, M. : RPE lipofuscin and its role in retinal pathobiology. Exp. Eye. Res. 80, 595 (2005). 

  27. Sparrow, J. R., Vollmer-Snarr, H. R., Zhou, J., Jang, Y. P., Jockusch, S., Itagaki, Y. and Nakanishi, K. : A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J. Biol. Chem. 278, 18207 (2003). 

  28. Mishima, H. and Kondo, K. : Extrusion of lysosomal bodies from apical mouse retinal pigment epithelium. Albrecht Von Graefes Arch. Klin Exp. Ophthalmol. 216, 209 (1981). 

  29. Young, R. W. : Solar radiation and age-related macular degeneration. Surv. Ophthalmol. 32, 252 (1988). 

  30. Tomany, S. C., Cruickshanks, K. J., Klein, R., Klein, B. E. and Knudtson, M. D. : Sunlight and the 10-year incidence of agerelated maculopathy: the Beaver Dam Eye Study. Arch. Ophthalmol. 122, 750 (2004). 

  31. Beatty, S., Koh, H., Phil, M., Henson, D. and Boulton, M. : The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45, 115 (2000). 

  32. Jones, C. A., Huberman, E., Cunningham, M. L. and Peak, M. J. : Mutagenesis and cytotoxicity in human epithelial cells by far- and near-ultraviolet radiations: action spectra. Radiat. Res. 110, 244 (1987). 

  33. Cousins, S. W., Espinosa-Heidmann, D. G., Alexandridou, A., Sall, J., Dubovy, S. and Csaky, K. : The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation. Exp. Eye. Res. 75, 543 (2002). 

  34. Brunk, U. T. and Terman, A. : Lipofuscin: mechanisms of agerelated accumulation and influence on cell function. Free Radic. Biol. Med. 33, 611 (2002). 

  35. Natural Medicine Comprehensive Database. : bog bilberry monograph. 

저자의 다른 논문 :

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로