[논문]The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children

Lee, Jae-Min; Hah, Jeong-Ok; Kim, Hee-Sun

doi:10.5142/jgr.2012.36.4.383

The Effect of Red Ginseng Extract on Inflammatory Cytokines after Chemotherapy in Children 원문보기

Journal of ginseng research = 高麗人參學會誌, v.36 no.4, 2012년, pp.383 - 390

Lee, Jae-Min (Department of Pediatrics, Yeungnam University College of Medicine) , Hah, Jeong-Ok (Department of Pediatrics, Yeungnam University College of Medicine) , Kim, Hee-Sun (Department of Microbiology, Yeungnam University College of Medicine)

Abstract ▼ AI-Helper

Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. Thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescence of the Yeungnam University Hospital from June 2004 to June 2009, were enrolled for the study. The study group consisted of 19 patients who received KRG extract (60 mg/kg/d) for 1 yr and 11 patients who did not receive KRG extract were the control group. Blood samples were collected every 6 mo. Immune assays included circulating lymphocyte subpopulation, serum cytokines (IL-2, IL-10, IL-12, TNF-alpha, and IFN-gamma), and total concentrations of serum IgG, IgA, and IgM subclasses. Age at diagnosis ranged from 2 mo to 15 yr (median 5 yr). Nine patients received stem cell transplantation. The cytokines of the KRG treated group were decreasing more rapidly than that of the control group. Lymphocyte subpopulations (T cell, B cell, NK cell, T4, T8, and T4/T8 ratio) and serum immunoglobulin subclasses (IgG, IgA, and IgM) did not show significant differences between the study and the control groups. This study suggests that KRG extract might have a stabilizing effect on the inflammatory cytokines in children with cancer after chemotherapy.

주제어

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문제 정의

However, there has been no data for the effects of KRG in children with cancer after completion of chemotherapy. The purpose of this study is to investigate the immune-modulatory effects of KRG in children after chemotherapy.

대상 데이터

Hematopoietic stem cell transplantation was done for 8 patients in the study group. Diagnoses of the subjects were acute leukemia, lymphoma and other solid cancers.
KRG extracts were supplied by Korea Ginseng Corporation (Seoul, Korea). Nineteen patients in the study group received KRG extract 60 mg/kg daily for 1 yr.
Nineteen patients, who received KRG extract for 1 yr, were included in the study group, while the control group consisted of 11 patients who did not receive KRG extract. This study was approved by the institutional review board (IRB) of Yeungnam University Medical Center (IRB no.
Thirty patients who were diagnosed and successfully completed chemotherapy or hematopoietic stem cell transplantation (HSCT) for leukemia, lymphoma or solid tumor, at the department of pediatrics and adolescence of the Yeungnam University Hospital from June 2004 to June 2009, were enrolled for the study.

데이터처리

Repeated ANOVA was used to compare the differences in the laboratory values between the study and the control groups, which were followed by multiple comparisons with the Bonferroni correction. Mann-Whitney U-test was used to compare the differences of the serum cytokines within the study group.

이론/모형

Repeated ANOVA was used to compare the differences in the laboratory values between the study and the control groups, which were followed by multiple comparisons with the Bonferroni correction. Mann-Whitney U-test was used to compare the differences of the serum cytokines within the study group.

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