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NTIS 바로가기생물정신의학 = Korean journal of biological psychiatry, v.19 no.1, 2012년, pp.29 - 37
The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a valid biomarker of central serotoninergic activity in humans. The specificity and sensitivity of the LDAEP to changes in serotonergic neurotransmission have recently been explored in many studies about pharmacolo...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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LDAEP는 무엇을 측정하는가? | LDAEP는 다른 용어로도 사용되어지는데, 몇몇 저자들은 Intensity Dependence of the Auditory Evoked Potential(이하 IDAEP)라는 표현을 사용하기도 한다.4-7) LDAEP는 비침습적 뇌파 측정을 이용하여 보통 다섯 가지 강도의 청각 자극을 제시한 후 약 100 ms에 나타나는 사건유발전위 반응의 변화를 측정한다. 우선 청각 자극을 제시한 후에 나타나는 사건 유발전위인 N100(N1)과 P200(P2) 간의 진폭의 차이를 측정하게 되는데(Fig. | |
세로토닌이 인간에게 미치는 영향은? | 세로토닌은 인체의 자율신경 조절에 광범위한 영향을 미치고 수면-각성 주기, 공격성, 감정, 불안, 성적 행동, 감각운동 반응성(sensorimotor reactivity) 및 학습 등의 행동 기능에도 영향을 미치는 것으로 알려져 있다.1) | |
다양한 정신과적 질환에서 LDAEP의 강도 수준은 어떻게 나타나는가? | 다양한 정신과적 질환에서 LDAEP의 강도수준이 다르게 나타날 수 있다.16)17) 특히 조현병과 양극성 장애에서 감소된 LDAEP가 관찰되고 있으며 주요우울증에서는 정상인과 유사한 정도의 LDAEP 소견을 보이고 있다. 불안장애의 여러 아형에서는 각 불안장애의 병리적 특징에 따라 차별적인 LDAEP 양상을 보이는 것으로 보고되고 있다. |
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