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꼬마선충에서 메밀 추출물에 의한 산화성 스트레스 저항성 증가 및 수명 연장 효과
Buckwheat Extract Increases Resistance to Oxidative Stress and Lifespan in Caenorhabditis elegans 원문보기

韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.21 no.1, 2013년, pp.1 - 6  

김철규 (순천향대학교 의료생명공학과) ,  박상규 (순천향대학교 의료생명공학과)

Abstract ▼ AI-Helper 아이콘AI-Helper

Buckwheat (Fagopyrum esculentum) has been known for having strong anti-oxidant, anti-mutagenic, and anti-carcinogenic activities. The free radical theory of aging, also known as the oxidative stress theory of aging, claims that cellular oxidative damage accumulated with time is a major causal factor...

주제어

#Buckwheat   #Oxidative Stress   #Lifespan   #Fertility   #C   #elegans  

AI 본문요약
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대상 데이터

  • Worms were transferred to fresh NGM plates with buckwheat and paraquat every 2 days. Sixty worms were scored in each group.
  • After removing five adults, the eggs were incubated at 20℃. Thirty young adults were picked 3 days after hatching and transferred to a fresh NGM plate. 12.

데이터처리

  • In the statistical analysis of lifespan assay, we excluded worms lost or killed during the assay. For fertility assay, we calculated p-value using standard two-tailed student t-test.

이론/모형

  • The log-rank test was employed for the statistical analysis of resistance to oxidative stress and lifespan assay. The log-rank test, also called as Mantel-Cox test, is a nonparametic test frequently used for comparing lifespan of two groups (Peto and Peto, 1972).
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참고문헌 (23)

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  9. Hwang EJ, Lee SY, Kwon SJ, Park MH and Boo HO. (2006). Antioxidative, antimicrobial and cytotoxic activities of Fagopyrum esculentum Moench extract in germinated seeds. Korean Journal of Medicinal Crop Science. 14:1-7. 

  10. Kreft I, Bonafacci G and Zigo A. (1994). Secondary metabolites of buckwheat and their importance in human nutrition. Food Technology and Biotechnology Review. 32:195-197. 

  11. Kim JY, Son BK and Lee SS. (2012). Effects of adlay, buckwheat, and barley on transit time and the antioxidative system in obesity induced rats. Nutrition Research and Practice. 6:208-212. 

    원문보기 상세보기 crossref

  12. Koh ES, Ju JS, Choi MG, Yoon TH, Ahn YS, Lim KJ, Kim SO and Kim JD. (2002). Effects of buckwheat, potato and rice on glycemic indices in healthy subjects. Korean Journal of Medicinal Crop Science. 10:253-258. 

    원문보기 상세보기

  13. Larsen PL, Albert PS and Riddle DL. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 139:1567-1583. 

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  14. Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R and Prolla TA. (2004). The impact of alphalipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radical Biology and Medicine. 36:1043-1057. 

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  15. Park SK, Kim K, Page GP, Allison DB, Weindruch R and Prolla TA. (2009). Gene expression profiling of aging in multiple mouse strains: Identification of aging biomarkers and impact of dietary antioxidants. Aging Cell. 8:484-495. 

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  16. Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R and Prolla TA. (2008). alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. Journal of Nutrition. 138:1010-1018. 

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  19. Sedej I, Sakac M, Mandic A, Misan A, Tumbas V and Canadanovic-Brunet J. (2012). Buckwheat(Fagopyrum esculentum Moench) grain and fractions: Antioxidant compounds and activities. Journal of Food Science. 77:c954-c959. 

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  22. Wood WB. (1988). The nematode Caenorhabditis elegans. Cold Spring Harbor Laboratory Press. Cold Spring Harbor. New York, USA. p.1-16. 

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