In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each $ID_{50}$ was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC...
In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each $ID_{50}$ was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each $ID_{50}$ was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats.
In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each $ID_{50}$ was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each $ID_{50}$ was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats.
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제안 방법
The goal of this study was to evaluate the gastroprotective effect of three flavonoids containing glucuronopyranoside in rats, and also compared GSH or MPO levels to determine gastroprotective and antioxidative effects.
대상 데이터
Male Sprague-Dawley rats with a body weight of about 200g were used for the experiments. The rats were housed in a controlled room (temperature of 22±20℃, relative humidity of 50±5%) with a defined light/dark cycle and were given a solid diet and tap water ad libitum.
데이터처리
Statistical differences between means were determined using the Student's t-test.
성능/효과
From the findings in this study, the 3 compounds were proven significantly and dose-dependently to protect effectively against the NSAIDs-induced gastric damage, which was more susceptible to NSAIDs by the administration of indomethacin in rats. The underlying mechanism of gastroprotective effects of the gastric damage induced by indomethacin could be related to its anti-oxidant properties, which reduce MDA levels, MPO activity.
It was confirmed the inhibition of reflux esophagitis by treatment of these 3 compounds. Thus QGC, AGC and omeprazole decreased the gastric volume significantly in a dose dependent manner, and each ID50 was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. However, ID50 of LGC was larger than 30 mg/kg (Table 1).
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