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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.28 no.6, 2013년, pp.31 - 38
박상욱 (뉴메드 한의과학기술연구소) , 권용범 (뉴메드 한의과학기술연구소) , 김기태 (세명대학교 한의과대학 내과학교실) , 신선미 (세명대학교 한의과대학 내과학교실) , 임강현 (세명대학교 한의과대학 본초학교실) , 고흥 (세명대학교 한의과대학 내과학교실) , 송미경 (경희대학교 한의과대학 본초학교실) , 정윤철 (경희대학교 한의과대학 본초학교실) , 김호철 (경희대학교 한의과대학 본초학교실) , 박주연 (뉴메드 한의과학기술연구소)
Objectives : The purpose of this study was to determine whether NMED-01 or NMED-02 improves laboratory test results in participants with liver function disorder. Methods : This is a randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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알코올성 간 질환의 발생빈도가 상대적으로 증가하고 있는 이유는? | 알코올성 간 질환은 B형 간염에 이어 만성 간질환 발생 원인의 18.6%를 차지하고 있으며, 사회, 문화, 관례적으로 허용되는 음주에 의해 발병하는 특성 때문에 의료인의 관심이 낮아 발생 빈도가 상대적으로 증가하고 있다1). | |
현재 사용되는 알코올성 간 질환의 치료법은? | 알코올성 간 질환을 치료하지 않으면 간경화로 진행되는데 금주 외에는 효과적인 치료방법이 없다2). 현재 치료법으로는 고칼로리, 비타민 무기질이 풍부한 영양식이나 심한 경우에는 당질 코르티코이드, pentoxifylline, anticytokine therapy, 대사개선을 위한 propylthiouracil, 간 섬유화를 억제하기 위한 colchicine 등이 사용된다3). 이러한 치료제들은 대증요법에 지나지 않는다. | |
헛개나무(Hovenia dulcis Thunb.)란? | 헛개나무(Hovenia dulcis Thunb.)는 갈매나무과의 낙엽교목으로 우리나라와 일본, 중국 등에 분포하며6-7), 지구자(枳椇子)라는 한약명으로 『唐本草』에 처음 기재된 이래 열매자루가 달린 열매 또는 씨를 사용하고 있으며8-9), 甘酸, 平하여 養陰生津, 補中益氣, 潤腸通便, 解酒毒의 효능으로 熱病煩渴, 嘔吐呃逆, 小兒疳積, 小便不利, 飮酒中毒 등에 사용되어 왔다10). 枳椇子에는 (+)-ampelopsin, laricetrin, myricetin, (+)-gallocatechin 등의 flavonoid류, hovenitin I, II, III 등의 flavonol류, frangulanine 등 alkaloid류11-12), hovenidulciosides A1, A2, B1, B2 등13-14)의 triterpene glycoside류 성분 등이 함유되어 있으며 항산화15-19), 아질산염 소거19), 알코올 분해6,19-20), 항암21-22), 항돌연변이22), 지질개선22), 항당뇨15,23), 간보호6,11-12,14,24-29) 등이 보고되어 있다. |
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