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비만환아에서 복약기간에 따른 비만탕의 치료효과 비교연구
Comparisons of Effects of Biman-tang according to Administration Period in Childhood Obesity 원문보기

大韓韓方小兒科學會誌 = The journal of pediatrics of Korean medicine, v.27 no.4, 2013년, pp.57 - 67  

임영권 (경희대학교 한의과대학 본초학교실) ,  민서림 (경희대학교 한의과대학 경혈학교실) ,  김희만 (경희대학교 한의과대학 본초학교실) ,  허광욱 (경희대학교 한의과대학 본초학교실) ,  이훈 (강남 아이누리 한의원) ,  이진수 (동서융합병원 한방내과) ,  김호철 (경희대학교 한의과대학 본초학교실) ,  박재우 (경희대학교 한의과대학 내과학교실) ,  박히준 (경희대학교 한의과대학 경혈학교실)

Abstract AI-Helper 아이콘AI-Helper

Objectives The purpose of this study is to investigate the safety and effect of Biman-tang (BMT) on two different administration periods in the treatment of childhood overweight and obesity. Methods In retrospective study, 39 overweight and obese ($85^{th}$ percentile ${\leq}$ ...

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제안 방법

  • Table 1 shows the composition of BMT. For each hospital visit, medical examination was performed to modify the prescription either by adding or eliminating its herbal constituents. In case of rhinitis, Magnolia denudate, Saposhnikovia divaricate and Mentha piperascens were added to the medication.
  • In order to evaluate the effects of BMT in obese and overweight children depending on the periods of treatment, they were divided into two groups of short-period (30 days) and long period (45~90 days). This study was exempted from IRB Review due to its retrospective study method.
  • Some clinical studies have been conducted to investigate safe dose of Ephedra sinica32-35). In this study, any occurrence of adverse effect and the effect in the treatment of obesity were monitored as the dose of Ephedra sinica was gradually increased in two groups. But dose of Ephedra sinica were maintained within 24 g per a day according to Kim et al33).
  • In this study, we investigated the effects and safety of BMT on two different treatment periods in the treatment of childhood overweight and obesity.

대상 데이터

  • Each child received a personal diagnosis. The dried herbs were purchased from H Oriental Pharm Center (Yongin, Korea). The samples were identified by Seong Ku Youm Oriental Pharmacy.
  • The dried herbs were purchased from H Oriental Pharm Center (Yongin, Korea). The samples were identified by Seong Ku Youm Oriental Pharmacy.
  • Out of 135 overweight and obese children admitted to Korean Medical Clinic from January 2006 to April 2013, 79 children were prescribed with BMT. The total number of the children included for the study was 39, and out of those children 19 were male and 20 were female (Figure 1). Table 3 shows the baseline characteristics of the patients.

데이터처리

  • The changes in baseline anthropometric data between pre-treatment and post-treatment were tested using paired t-tests. Comparisons of height, weight, BMI and OI between Short-period (SP) treatment group and long-period (LP) treatment group were made using ANCOVA, adjusted for covariates. The covariates were: (1) age, sex and percentile of variables at pre-treatment (height and weight variables); (2) age, sex and variables at pre-treatment (BMI and OI variables).
  • Values are mean ± SD. Independent t-test was used for analyzing changes on total data in both groups.
  • , Chicago, USA). The changes in baseline anthropometric data between pre-treatment and post-treatment were tested using paired t-tests. Comparisons of height, weight, BMI and OI between Short-period (SP) treatment group and long-period (LP) treatment group were made using ANCOVA, adjusted for covariates.

이론/모형

  • Fisher’s exact test was used to compare the relevance of the adverse effects between groups.
  • Safety and tolerability were analyzed using Common Terminology Criteria for Adverse Events (CTCAE). CTCAE v4.
  • In order to evaluate the effects of BMT in obese and overweight children depending on the periods of treatment, they were divided into two groups of short-period (30 days) and long period (45~90 days). This study was exempted from IRB Review due to its retrospective study method.
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