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NTIS 바로가기韓國家畜衛生學會誌 = Korean journal of veterinary service, v.37 no.1, 2014년, pp.35 - 43
김성재 (강원대학교 수의과대학.동물종합연구소) , 김재훈 (씨티씨바이오(주)) , 전수연 (인트론바이오테크놀로지(주)) , 백형록 (인트론바이오테크놀로지(주)) , 한정희 (강원대학교 수의과대학.동물종합연구소)
Salmonellosis has caused heavy losses in swine industry and implications for public health. Recently, the urgent problem of antibiotic resistance due to multidrug-resistant Salmonella spp. has been on the rise. The use of host-specific bateriophages as a biocontrol is one possible alternative. In th...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
박테리오파지가 사용되는 곳은? | 박테리오파지는 1910년도에 D'Herelle와 Twort에 의해서 최초로 발견되었으며(D'Herelle 등, 1922), 세균성 질병의 예방과 치료제로 사용되었다. 초기 연구는 체계적인 실험이 수행되지 않았으며, 항생제를 포함한 화학요법의 빠른 발전으로 박테리오파지에 대한 연구가 지속되지 못했다(Barrow와 Soothill, 1997). | |
S. Typhimurium의 병증은? | S. Typhimurium의 감염은 설사 이외에도 발열, 황달, 패혈증 등 전신증상을 유발하여 폐사시키며 이환율과 폐사율이 높다고 알려져 있고 다양한 경로로 감염이 이루어질 수 있다(Kapperud 등, 1990; Khakhria 등, 1991; Sarwari 등, 2001). | |
박테리오파지를 이용한 치료법에 대한 관심이 증가하고 있는 이유는? | 초기 연구는 체계적인 실험이 수행되지 않았으며, 항생제를 포함한 화학요법의 빠른 발전으로 박테리오파지에 대한 연구가 지속되지 못했다(Barrow와 Soothill, 1997). 최근 항생제 내성을 가진 병원성 세균의 출현 및 증가가 문제되고 있으며(Aarestrup, 1999; Goode 등, 2003), 막대한 비용을 들여 항생제 내성균에 작용하는 새로운 항생제를 개발한다고 해도 새로운 항생제에 내성을 가진 병원체가 출현할 가능성이 있어 대체할 치료 전략이 필요한 실정이다(Aarestrup, 1999; Biswas 등, 2002; Matsuzaki 등, 2005). 이와 같은 문제를 해결하기 위해 최근 항생제가 개발되기 이전 시대의 치료법에 대한 관심이 높아지고 있으며, 박테리오파지를 이용한 치료법에 대한 관심이 증가하고 있다(Barrow와 Soothill, 1997; Biswas 등, 2002). |
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