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Pleural Infection and Empyema 원문보기

Tuberculosis and respiratory diseases : TRD = 결핵 및 호흡기 질환, v.76 no.4, 2014년, pp.160 - 162  

Kwon, Yong Soo (Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School)

Abstract AI-Helper 아이콘AI-Helper

Increasing incidence of pleural infection has been reported worldwide in recent decades. The pathogens responsible for pleural infection are changing and differ from those in community acquired pneumonia. The main treatments for pleural infection are antibiotics and drainage of infected pleural flui...

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성능/효과

  • Combined t-PA and DNase therapy were significantly improved in both primary and secondary outcomes compared to those in placebo group, but t-PA alone or DNase alone did not produce any significant difference in primary and secondary outcomes compared to those in the placebo group. However, the absolute difference in number of surgical referrals was only one between t-PA group (3/48) and t-PA-DNase group (2/48), although only the t-PA-DNase group had a statistical significant difference compared to the placebo group. The number of enrolled patients may not have been enough to provide robust evidence for the routine use of these agents for pleural infection.

후속연구

  • Several retrospective studies reported high success rates with low complication rates in multiloculated empyema16,17. However, since there was no randomized study for the utility and safety of this procedure in pleural infection, further prospective comparative studies are needed.
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참고문헌 (20)

  1. 1 Burgos J Falco V Pahissa A The increasing incidence of empyema Curr Opin Pulm Med 2013 19 350 356 23508113 

  2. 2 Grijalva CG Zhu Y Nuorti JP Griffin MR Emergence of parapneumonic empyema in the USA Thorax 2011 66 663 668 21617169 

  3. 3 Davies HE Davies RJ Davies CW BTS Pleural Disease Guideline Group Management of pleural infection in adults: British Thoracic Society Pleural Disease Guideline 2010 Thorax 2010 65 Suppl 2 ii41 ii53 20696693 

  4. 4 Aleman C Alegre J Monasterio J Segura RM Armadans L Angles A Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions Clin Sci (Lond) 2003 105 601 607 12826021 

  5. 5 Kroegel C Antony VB Immunobiology of pleural inflammation: potential implications for pathogenesis, diagnosis and therapy Eur Respir J 1997 10 2411 2418 9387973 

  6. 6 Idell S Girard W Koenig KB McLarty J Fair DS Abnormalities of pathways of fibrin turnover in the human pleural space Am Rev Respir Dis 1991 144 187 194 2064128 

  7. 7 Maskell NA Batt S Hedley EL Davies CW Gillespie SH Davies RJ The bacteriology of pleural infection by genetic and standard methods and its mortality significance Am J Respir Crit Care Med 2006 174 817 823 16840746 

  8. 8 Marks DJ Fisk MD Koo CY Pavlou M Peck L Lee SF Thoracic empyema: a 12-year study from a UK tertiary cardiothoracic referral centre PLoS One 2012 7 e30074 22276145 

  9. 9 Kim YJ Cha SI Kwon JS Yoo SS Jun HJ Kim EJ Treatment results and prognostic factors of complicated parapneumonic effusion and empyema Tuberc Respir Dis 2007 63 24 30 

  10. 10 Menzies SM Rahman NM Wrightson JM Davies HE Shorten R Gillespie SH Blood culture bottle culture of pleural fluid in pleural infection Thorax 2011 66 658 662 21459855 

  11. 11 Rahman NM Maskell NA Davies CW Hedley EL Nunn AJ Gleeson FV The relationship between chest tube size and clinical outcome in pleural infection Chest 2010 137 536 543 19820073 

  12. 12 Maskell NA Davies CW Nunn AJ Hedley EL Gleeson FV Miller R U.K. Controlled trial of intrapleural streptokinase for pleural infection N Engl J Med 2005 352 865 874 15745977 

  13. 13 Corcoran JP Hallifax R Rahman NM New therapeutic approaches to pleural infection Curr Opin Infect Dis 2013 26 196 202 23286936 

  14. 14 Rahman NM Maskell NA West A Teoh R Arnold A Mackinlay C Intrapleural use of tissue plasminogen activator and DNase in pleural infection N Engl J Med 2011 365 518 526 21830966 

  15. 15 Janda S Swiston J Intrapleural fibrinolytic therapy for treatment of adult parapneumonic effusions and empyemas: a systematic review and meta-analysis Chest 2012 142 401 411 22459772 

  16. 16 Brutsche MH Tassi GF Gyorik S Gokcimen M Renard C Marchetti GP Treatment of sonographically stratified multiloculated thoracic empyema by medical thoracoscopy Chest 2005 128 3303 3309 16304276 

  17. 17 Ravaglia C Gurioli C Tomassetti S Casoni GL Romagnoli M Gurioli C Is medical thoracoscopy efficient in the management of multiloculated and organized thoracic empyema? Respiration 2012 84 219 224 22832393 

  18. 18 Chambers A Routledge T Dunning J Scarci M Is video-assisted thoracoscopic surgical decortication superior to open surgery in the management of adults with primary empyema? Interact Cardiovasc Thorac Surg 2010 11 171 177 20439299 

  19. 19 Chung JH Lee SH Kim KT Jung JS Son HS Sun K Optimal timing of thoracoscopic drainage and decortication for empyema Ann Thorac Surg 2014 97 224 229 24119984 

  20. 20 Shin JA Chang YS Kim TH Haam SJ Kim HJ Ahn CM Surgical decortication as the first-line treatment for pleural empyema J Thorac Cardiovasc Surg 2013 145 933 939 22929218 

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