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NTIS 바로가기大韓韓方小兒科學會誌 = The journal of pediatrics of Korean medicine, v.28 no.3, 2014년, pp.31 - 46
이진화 (대전대학교 한의과대학 소아과학교실) , 한재경 (대전대학교 한의과대학 소아과학교실) , 김윤희 (대전대학교 한의과대학 소아과학교실)
Objectives Forsythiae Fructus treatment has been used for inflammatory and allergic diseases in Korean Medicine. Nevertheless, the mechanism of action and the cellular targets are not understood well. The pathogenesis of allergic diseases are associated with Th2 cytokines such as IL-13, MIP-
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핵심어 | 질문 | 논문에서 추출한 답변 |
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아토피 피부염의 특징은 무엇인가? | 아토피 피부염은 영, 유아기의 대표적인 알레르기질환으로 재발이 잦고 만성으로 경과하는 염증성 질환으로 심한 소양감과 함께 홍반, 부종, 삼출, 가피, 인설, 태선화 등을 특징으로 한다26). | |
CD4+ T세포의 종류인 Th1과 Th2는 각각 어떤 반응에 관여하는가? | 인체에 항원이 침입하였을 때 T세포에 의해 면역이 조절되는데 CD4+ T세포는생성하는 사이토카인의 종류에 따라 Th1과 Th2로 분류된다28). Th1 세포는 IFN-γ, IL-2 등을 특징적으로 분비하며 세균 감염에 있어서 방어적 기능을 담당하고 지연형 과민 반응에 관여하며35), Th2 세포는 IL-4, IL-5, IL-10, IL-13, IL-16 등 일련의 사이토카인을 분비하는데, 이 중 IL-4와 IL-13은 B세포에서 IgE 생성을 유도하고, IL-5는 호산구의 분비, 분화와 성숙에 관여하여 즉시형 아토피 반응에 관여한다36). IL-3, TNF-α, GM-CSF 는 두 세포 모두에서 특징적으로 분비되는 사이토카인으로 염증 반응을 일으키며 비만세포의 발달에 영향을 미치는 것으로 알려져있다37). | |
連翹는 무엇인가? | 連翹 (Forsythiae Fructus)는 물푸레나무과 (木犀科, Oleaceae) 속하는 개나리 (Forsythia densitolra Nakai)와의성개나리 (Forsythia viridissima Lindley)의 과실을 건조한 것으로 약성이 平하고 苦味를 가지고 있으며 淸熱과 消腫의 작용을 통해 瘡瘍腫毒과 瘰癧結核을 치료하는 聖藥으로 알려져 있으며 癰疽, 乳癰, 丹毒 등 피부과 염증 질환에도 응용된다1-6). 현대에서 아토피피부염의 내치 또는 외치 요법에 다용되고 있으며7,8) 접촉성 피부염에도 사용되고 있다9). |
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