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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.29 no.6, 2014년, pp.165 - 173
하미애 (경남과학기술대학교 농학.한약자원학부) , 김진우 (경남과학기술대학교 농학.한약자원학부) , 이신우 (경남과학기술대학교 농학.한약자원학부) , 전현식 (경남과학기술대학교 농학.한약자원학부) , 조영손 (경남과학기술대학교 농학.한약자원학부) , 신용욱 (경남과학기술대학교 농학.한약자원학부)
Objectives : Platycodon Root is frequently used in traditional medicine to treat inflammatory diseases of the throat. The purpose of this study was to characterize the effect of the EtOH extract of fermented Platycodon grandiflorum on the ameliorative effects on the Antipruritic Effect of atopic der...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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알레르기로 인한 소양행동이 증가된 마우스와 난알부민 감작으로 알레르기 면역반응이 유도된 마우스에서, 발효길경 80% 에탄올추출물의 알레르기 조절효과는 무엇인가? | 본 연구결과로부터 발효 길경의 80% 에탄올추출물은 알레르기 면역반응 유도 매개물질들의 분비를 감소시키고, 체내의 항산화계를 회복시킴으로써 알레르기로 인한 피부질환 치료에 효과적일 것으로 사료된다. | |
길경은 무엇인가? | 길경(桔梗, Platycodi Radix)은 초롱꽃과(桔梗科: Campanulaceae)에 속하는 도라지(Platycodon grandiflorum a. (Jacq) DC.)의 뿌리1)로 특히 중국 및 일본과 함께 우리나라에서만 유일하게 자생하는 식물로 예로부터 식용 및 약용으로 사용2)되어져 왔으며 특히 1∼2년근과는 달리 3년근 이상은 약용으로 중요시되어 왔다3). 에도 "治肺氣喘促 下一切氣 療咽喉痛及胸脇諸痛 下蠱毒"에서 언급4)한바와 같이 길경은 宣肺利咽, 祛痰排膿 등의 효능으로 咳嗽痰多, 胸悶不暢, 咽痛音啞, 肺癰吐膿, 瘡瘍膿成不潰 등의 치료에 이용되어지고 있다5). | |
아토피는 면역학적인 측면에서 어떠한가? | 아토피는 면역학적인 측면에서 살펴보면, 급성병변의 경우 Th2세포 반응에 의한 IL-4, 5, 10의 증가, Th-1세포에서 분비되는 interferon(IFN-γ)의감소, 비만세포의 증가 등이 병의 발생과 상관있으며, 이후 IL-12에 의해 Th-1세포 반응이 활성화되어 병변의 만성화가 진행 된다17). 아토피피부염에서 IFN-γ와 IL-2를 투여하였을 때 피부염이 호전되었다는 보고는 Th-1/Th-2 불균형이 아토피피부염의 병인에 중요함을 제시해준다18,19). |
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