최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기디지털융복합연구 = Journal of digital convergence, v.13 no.1, 2015년, pp.341 - 351
승윤철 (대전대학교 보건스포츠 대학원 대체의학과) , 정규진 (충남대학교 약학대학 약학과) , 정광조 (대전대학교 뷰티건강관리학과)
This study was aimed to evaluate the effects of Cypress oil(CS) on anti-asthmatic activities in a mouse model of allergic asthma. Using an Ovalbumin-induced allergic asthma mouse model, 0.3% of CS was administered to experimental group using a nebulizer for 3 weeks on a basis of 3 times per week and...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
천식은 무엇인가? | 산업화가 빠른 속도로 진행됨에 따른 대기 오염의 가속화, 흡연 인구의 증가, 새로운 항원의 출현 등이 원인으로 작용하여 천식의 발생은 그 이전에 비해 두 배 이상 증가되는 양상을 띠고 있으며[1], 천식으로 인한 사망률 또한 증가하고 있다. 기관지 과민성과 기도 내 염증에 의한 가역적인 기도 폐쇄가 특징적인 호흡기계 질환인 천식은 기도 내로 흡입된 여러 가지 항원에 의하여 T 세포, B 세포, 호산구, 호중구 및 비만세포 등의 염증세포들에 의해 유발되는데 이 중 호산구가 가장 주요한 유발세포로 알려져 있다[2]. | |
천식의 치료제로 스테로이드를 장기적으로 사용할 때 어떤 부작용이 발생하는가? | 천식의 치료제는 항염증 효과를 목표로 하는 스테로이드와 같은 증상 조절제와 기관지 확장제와 같이 속효성을 보이는 증상완화제가 있으며 현재까지 가장 효과적인 치료제는 스테로이드이다[6]. 그러나 장기적으로 사용될 경우, 부신기능억제, 골다공증, 골절, 성장지연, 혈압상승 등의 부작용들이 보고되고 있다. 따라서 장기적인 적용이 가능하면서 부작용이 없고, 근본적으로 천식을 치료할 수 있는 천연물 성분을 이용한 천식치료제의 개발이 요구되고 있다. | |
싸이토카인은 무엇인가? | 싸이토카인은 생체의 면역 조절 및 방어에 중요한 역할을 담당하는 생리 활성물질로, Th2 세포의 분화, IgE 생산 또는 호산구의 증식 등의 알러지성 염증에 관여하고 있다. |
Hartert.T.V., Peebles.R.S., Epidemiology of asthma; the year of review. Curr. Opin. Pulm. Med, Vol. 6, pp. 4-9, 2000.
Busse, WW., Lemanske Jr., RF., Asthma. N Engl J Med, Vol. 344, No.5, pp. 350-362, 2001.
James J.,Lee, Dawn Dimina, MiMi P.Macias, Sergei I.Ochkur, Michael P.MacGarry, Katie R.O 'Neill, Cheryl Protheroe, Ralph Pero, Thanh Nguyen, Stephania A.Cormier, Elizabeth Lenkiewicz, Dana Colbert, Lisa Rinaldi, Steven J.Ackerman, Charles G.Irvin, Nancy A.Lee., Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils. SCIENCE, Vol. 305, pp. 1773-1776, 2004.
Alison A. Humbles, Clare M.Lloyd, Sarah J. McMillan, Daniel S.Friend, Georgina Xanthou, Erin.E.McKenna, Sorina Chiran, Norma P.Gerard, ChanningYu, Stuart H.Orkin, CraigGerard, A Critical Role for Eosinophils in Allergic Airways Remodeling. SCIENCE, Vol. 305, pp. 1776-1779, 2004.
Zhou Zhu, Tao Zheng, Robert J.Homer, Yoon-Keu -n Kim, Ning Yuan Chen, Lauren Cohn, Qutayba Hamid, Jack A.Elias., Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathwa-y Activation. SCIENCE, Vol. 304, pp. 1678-1682, 2004.
Sung-Hwahn Hahn, The Effect of Essential Oils from Citron, Pine Tree, Chamaecyparis pisifera and Chamaecyparis obtusa on IL-8 Transcription and Secretion. M.S. dissertation, Dankook University. p. 27, 2011.
Niazi, J., Singh, P., Bansal, Y., and Goel, R., Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica. Inflammopharmacol, Vol. 17, No. 4, pp. 239-244, 2009.
Sung-Hwahn Hahn, The Effect of Essential Oils from Citron, Pine Tree, Chamaecyparis pisifera and Chamaecyparis obtusa on IL-8 Transcription and Secretion. M.S. dissertation, Dankook University. p. 2, 2011.
Sousa OV, Silverio MS, Del-Vechio-Vieira G, Matheus FC, Yamamoto CH and Alves MS., Antinociceptive and anti-inflammatory effects of the essential oil from Eremanthus erythropappus leaves. J Pharm Pharmacol, Vol. 60, No. 6, pp. 771-777, 2008.
Chorianopoulos N, Evergetis E, Mallouchos A, Kalpoutzakis E, Nychas GJ, Haroutounian SA., Characterization of the essential oil volatiles of Satureja thymbra and Satureja parnassica: influence of harvesting time and antimicrobial activity. J Agric Food Chem, Vol. 54, No. 8, pp. 3139-3145, 2006.
Burke BE, Baillie JE, Olson RD., Essential oil of Australian lemon myrtle (Backhousia citriodora) in the treatment of molluscum contagiosum in children. Biomed Pharmacother, Vol. 58, No. 4, pp. 245-247, 2004.
Ait Mbarek L, Ait Mouse H, Elabbadi N, Bensalah M, Gamouh A, Aboufatima R, et al. Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Braz J Med Biol Res, Vol. 40, No. 6, pp. 839-847, 2007.
Kawashima H, Tateishi N, Shiraishi A, Teraoka N, Tanaka T, Tanaka A, et al. Oral administration of dihomo-gamma-linolenic acid prevents developme-nt of atopic dermatitis in NC/Nga mice. Lipids, Vol. 43, No. 1, pp. 37-43, 2009.
Hye-youn Lee, The Effect of Nebulized Frankincense Essential Oil in an OVA-Induced Allergic Asthma Mouse Model. Ph.D. dissertation, Konkuk University. 2009.
Kyung-Hee Hyun, Youn-Seup Kim, Jeung-Keun Suh, Sung-Hwahn Hahn, Do-Hyung Kim, Jae-Suk Park and Young-Koo Jee, The Suppressive Effect of Essential Oils from Plants on Interleukin-8 from Airway Epithelial Cell. Korean J Asthma Allergy Clin Immunol., Vol. 31, pp. 272-280, 2011.
Young-Kyung Jeon, Inhibitory Effect of the Induced Allergic Asthma Murine by Peppermint Inhlalation Therapy. M.S. dissertation, Daejeon University. 2010.
Kyung-ah Seo, The Antibacterial Effect of Chamaecyparis obtusa on Malassezia furfur and Its Effect on Dandruff Scalp. M.S. dissertation, Konkuk University. 2013.
Ji-Young Jung, Antibacterial Effect with essential oil from Hinoki cypress on skin microbiota. M.S. dissertation, Kwangju Women's University. 2011.
Ye-hyun Lee, Antimicrobial effect of Chamaecyparis obtusa and Thuja orientalis essential oils on Staphylococcus pseudintermedius isolated from canine skin and ears. M.S. dissertation, Seoul National University, 2014.
Seon-Hong Kim, Whitening effect and antioxidant activity of essential oils from Cryptomeria japonica and Chamaecyparis obtusa. M.S. dissertation, Seoul National University. 2011.
Seong-Kyeom Kim, Modulatory Effect of Chamaecyparis obtusa Leaf Essential Oils on Airway Hyperresponsiveness and Inflammation in a Murine Model of Allergic Asthma. M.S. dissertation, Chungbuk National University. 2014.
So-Eun Cho, Anti-oxidative, Anti-inflammatory and Immunomodulatory effects of Chamaecyparis obtusa Leaves Extracts for Atopic Dermatitis. Ph.D. dissertation, Konkuk University. 2012.
Imededdine Arbi Nehdi, Cupressus sempervirens var. horizentalis seed oil: Chemical composition, physicochemical characteristics, and utilizations. Industrial Crops and Products, Vol. 41 pp. 381-385, 2013.
Samy A Selim, Mohammed E Adam, Sherif M Hassan and Abdulrhman R Albalawi, Chemical composition, antimicrobial and antibiofilm activity of the essential oil andmethanol extract of the Mediterranean cypress (Cupressus sempervirens L.). Complementary and Alternative Medicine, Vol. 14. p. 179, 2014.
Sedigheh Asgary, Gholam Ali Naderi, Mohammad Reza Shams Ardekani, Amirhossein Sahebkar, Atousa Airin, Sanaz Aslani, Taghi Kasher, and Seyed Ahmad Emami, Chemical analysis and biological activities of Cupressus sempervirens var. horizontalis essential oils. Pharmaceutical Biology, Vol. 51, No. 2, pp. 137-144, 2013.
Myung-Won Joo, Ju-Youn Kim, The Hindrance Effect of Essential Oil on the Growth of Scalp Microorganisms -Focused on Clary Sage, Eucalyptus, Cypress Geranium, Lemon Grass. Jounal of The Korean Society of cosmetology, Vol.18 No.2, 2012.
Yu-Hyeon Shin, A Study on Compound Analysis and Effect of Biological activity and Antimicrobial for Natural Essential oil in Cosmetics Industry. M.S. dissertation, Daegu Haany University. 2013.
Young-Han Yun, Kyong-Soon Kim, Hye-Young Oh, Byong-Soo Yu, Ki-Young Kim, A Screening of 5 Species Essential Oil's Safety by the Observation of Cytotoxicity and Morphological Change on Cells. J, Kor, Soc. Cosm. Vol. 14, No. 3, 2008.
Hye-Youn Lee, Kum-Lan Kim, Mi-young Yun, Sang-Mo Kang, The effect of essentail oil mixture in a mouse model of allergic asthma. The Korean Society for Aesthetics and Cosmetology, Vol.7 No.1, 2009.
Sim Myoung Ki, Change of inflammatory markers in induced sputum in suspected asthmatics by anti-asthma treatment. Ph.D. dissertation, Chonnam National University. 2012.
Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV., Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol., Vol. 108, pp. 753-8, 2001.
Louis R, Lau LC, Bron AO, Roldaan AC, Radermecker M, Djukanovic R., The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med, Vol. 161, pp. 9-16, 2000.
Ulinska D, Szmidt M. Usefulness of the eosinophil count in induced sputum of asthmatic patients. Pneumonol Alergol Pol., Vol. 69, No. 9-10, pp. 581-589, 2001.
Maneechotesuwan K, Essilfie-Quaye S., Kharitonov SA, Adocock IM and Bames PJ., Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils. Chest, Vol. 132, No. 1, pp.98-105, 2007.
Seung-Yeon Jeong, Effects of Salviae miltiorrhizae on inflammatory cells associated with asthma via splenocyte, BMMC, eosinophil. Ph. D. dissertation, Kyung Hee University. 2009.
Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony-Lafontaine J, Godard P., Eosinophilic inflammation in asthma. N Engl J Med, Vol. 323, No. 15, pp. 1033-1039, 1990.
Jong-Tae Cha, Anti-asthmatic activities of leaves of Eribotrya japonica Lindley in a mouse model of allergic asthma. Ph.D. dissertation, Sangji University. 2012.
Homer A. Boushey, MD., New and Exploratory Therapies for Asthma. CHEST, Vol. 123, pp. 439-445, 2003.
Lee JH, Mcore JH, Park SW, Jang As, Uh ST, Kim YH, Park CS, Park BL and Shin HD, Genetic interactions model among Eotaxin gene polymorphisms in asthma. J. Hum. Genet, Vol. 53, No. 10, pp. 867-875, 2008.
Fulkerson PC, Fischetti CA and Rothenberg ME, Eosinophlis and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am. J. Pathol., Vol. 169, No. 6, pp. 2117-2126, 2006.
Lee SY, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS. and Park SH, Distribution and cytokine production of CD4 and CD8 T-lymphocyte subsets in patients with acute asthma attacks, Ann. Allergy Asthma Immunol., Vol. 86, No. 6, pp. 659-664, 2001.
Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, Tsushima F, Hoshino T, Aizawa H, Akiba H, Pardoll D, Hara N, Yagita H, Azuma M and Nakanishi Y, B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism, J. Immunol., Vol. 172, No. 4, pp. 2530-2541, 2004.
Lauren Cohn, Jack A. Elias, and Geoffrey L. Chup. ASTHMA: Mechanisms of Disease Persistence and Progression. Annu. Rev. Immunol, Vol. 22, pp. 789-81, 2004.
Hanmelmann E, Gelfand EW : IL-5-induced airway eosinophilia-the key to asthma? Immunol Rev, Vol. 179, pp. 182-191, 2001.
Young-Su An, Eotaxin and IL-5 in the sputum of the patients with stable bronchial asthma and with eosinodhilic bronchitis. M.S. dissertation, Soon Chun Hyang University. 2000.
Lee BR, Hong KE, Jang SG : The experimental study on the immuno-regulatory effect of notopterygii rhizoma herbal-acupuncture at Pyeus(BL13) on OVA-induced asthma in mice, The Korean Journal of Meridian & Acupoint, Vol. 22, pp. 107-125, 2005.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.