[논문]난소절제 흰쥐에서 엉겅퀴 추출물의 골다공증 보호 효과

김영옥; 김진성; 이상원; 조익현; 나세원

doi:10.7783/kjmcs.2015.23.1.1

난소절제 흰쥐에서 엉겅퀴 추출물의 골다공증 보호 효과
Osteoprotective Effect of Extract from Cirsium japonicum var. ussuriense in Ovariectomized Rats 원문보기

韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.23 no.1, 2015년, pp.1 - 7

김영옥 (농촌진흥청 국립원예특작과학원 인삼특작부) , 김진성 (농촌진흥청 국립원예특작과학원 인삼특작부) , 이상원 (농촌진흥청 국립원예특작과학원 인삼특작부) , 조익현 (농촌진흥청 국립원예특작과학원 인삼특작부) , 나세원 (전북대학교 수의과대학)

Abstract ▼ AI-Helper

This study was carried out to investigate the effects of the Cirsium japonicum var. ussuriense (C. japonicum) extract on serum level of hormones from induced osteoporosis by ovariectomized rats. Two month-old rats were ovariectomized (OVX), remained untreated for 8 weeks, and were subsequently administered C. japonicum (200 mg/kg) every day for 8 weeks. We examined the effects of treated C. japonicum on ovariectomy-related changes in Insulin-like Growth Factors (IGF), Insulin-like Growth Factor binding protein-3 (IGBF-3), Estrogen, Calcium, and Phosporus. After 8 weeks, the serum levels of IGF-I, -II, and IGFBP-3 were higher presented as compared to the other two groups (P < 0.05), in the C. japonicum extract treatment on OVX rats. There were differences between OVX and C. japonicum extract treated OVX rats in serum levels of $Ca^{2+}$, but $Ca^{2+}$ levels for the normal group was higher than for the other two groups. The C. japonicum extract increased both serum IGFs and IGFBP-3 levels on induced osteoporotic rat by ovariectomized. Thus, these results revealed that the C. japonicum extract is a possible role for improvement of osteoporosis induced-ovariectomized rats and has a great potential as an alternative tool for the treatment of osteoporosis.

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가설 설정

(b) carbon in the substrate as a function of de-binding temperature and atmosphere.
(b) carbon in the substrate as a function of gas nitriding temperature.

제안 방법

For the density of the green sheets, the mean density and the standard deviation were obtained for 10 samples per content by the dimension measurement, while the surface condition of the sheets was checked by using an optical microscope.
To obtain slurry formulation for preparation of green sheets, the P/S ratio were varied and the viscosity of slurry as well as the density and the surface condition of the green sheets were evaluated, allowing the optimum composition to be obtained.
To optimize the binder burnout conditions considering the nitriding process, Si green sheets with oxides as sintering aids were prepared, followed by binder burnout at 400℃ under the oxidizing and the inert atmospheres and nitriding processing at 1400℃ and 1450℃, respectively, and then the contents of residual oxygen and carbon present inside the specimens were measured.

대상 데이터

As a solvent, ethanol and toluene mixed by 50 vol% each was used, while PVB(BMSZ, >97%, SEKISUI Chemical Co., LTD, Japan) for the organic binder, DOP(Dioctyl phthalate, 99%, SAMCHUN Chemical, Korea) for the plasticizer, copolymer series (DISPERBYK®-111, Altana Co., Germany) for the dispersant were employed.

성능/효과

According to the analysis results for the residual oxygen content, about 2.9 wt% of the residual oxygen was detected at room temperature irrespective of the atmospheres, which is considered to be caused by the oxygen contained in the organic binder (PVB, (C8H14O2 )n) and the plasticizer (DOP, C6H4(COOC8H17)2) added to the green sheet.
In conclusion, it may be seen that implementation of binder burnout for green sheets under the oxidizing atmosphere near 400℃ with consideration of the residual oxygen and carbon contents is effective for the minimization of the residual oxygen and carbon contents which can affect thermal and mechanical properties upon manufacturing of the reaction sintered Si3N4 substrates through the tape-casting process with the high-purity Si powder as the starting raw material.

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