양한방 복합투여로 장기간 생존을 보인 폐암 환자 2례 Long-Term Survival of Patients with Lung Cancer Treated by Traditional Korean Medicine Combined with Western Treatment: Report of Two Cases원문보기
목 적: 소세포 폐암 및 전이성 폐암은 폐암 중에서도 가장 예후가 불량하고 생존율도 상대적으로 낮은 암으로 알려져 있다. 난치성 폐암 환자에 대해 한방치료가 생존 기간 연장 및 삶의 질 관리면에 있어서 효과가 있음을 보여주고자 한다. 연구방법 및 대상: 본원에서 입원 및 통원치료를 병행한 소세포폐암 환자 1명과 원발성 간암에서 폐로 전이된 전이성 폐암 환자 1명에 대하여 한방치료의 효과 및 임상경과를 후향적으로 조사하였다. 치료기간은 각각 2000년 1월-2009년 12월과 2004년 9월-2014년 2월이었으며 한약치료는 평균 1개월 간격으로 행해졌으며 입원기간 동안에는 한약치료를 포함한 침구치료를 추가로 시행하였다. 치료효과 및 경과 판정을 위해 흉부 방사선 검사 및 혈액검사를 평균 1개월 간격으로 시행하였으며 내원시마다 환자의 증상 및 상태를 확인하였다. 결 과: 2명의 폐암 환자 모두 꾸준한 한방치료를 받으며 진단시점부터 9년 이상의 상당히 오랜 기간 동안 비교적 좋은 삶의 질을 유지하면서 종양으로 인한 임상경과 또한 완만하게 진행이 되었다. 결 론: 본 증례는 한방치료가 불응성 폐암 환자에 대해 삶의 질을 양호하게 유지하고 증상 조절 및 종양의 진행양상을 완화시켜 주며 나아가 생존기간 연장에도 효과가 있음을 보여준다.
목 적: 소세포 폐암 및 전이성 폐암은 폐암 중에서도 가장 예후가 불량하고 생존율도 상대적으로 낮은 암으로 알려져 있다. 난치성 폐암 환자에 대해 한방치료가 생존 기간 연장 및 삶의 질 관리면에 있어서 효과가 있음을 보여주고자 한다. 연구방법 및 대상: 본원에서 입원 및 통원치료를 병행한 소세포폐암 환자 1명과 원발성 간암에서 폐로 전이된 전이성 폐암 환자 1명에 대하여 한방치료의 효과 및 임상경과를 후향적으로 조사하였다. 치료기간은 각각 2000년 1월-2009년 12월과 2004년 9월-2014년 2월이었으며 한약치료는 평균 1개월 간격으로 행해졌으며 입원기간 동안에는 한약치료를 포함한 침구치료를 추가로 시행하였다. 치료효과 및 경과 판정을 위해 흉부 방사선 검사 및 혈액검사를 평균 1개월 간격으로 시행하였으며 내원시마다 환자의 증상 및 상태를 확인하였다. 결 과: 2명의 폐암 환자 모두 꾸준한 한방치료를 받으며 진단시점부터 9년 이상의 상당히 오랜 기간 동안 비교적 좋은 삶의 질을 유지하면서 종양으로 인한 임상경과 또한 완만하게 진행이 되었다. 결 론: 본 증례는 한방치료가 불응성 폐암 환자에 대해 삶의 질을 양호하게 유지하고 증상 조절 및 종양의 진행양상을 완화시켜 주며 나아가 생존기간 연장에도 효과가 있음을 보여준다.
Objectives : To evaluate the long-term survival effects of traditional Korean medicine (TKM) on refractory metastatic lung cancer and small cell lung cancer (SCLC), which have historically poor survival rates. Methods : A retrospective study was conducted using the medical records of two patients in...
Objectives : To evaluate the long-term survival effects of traditional Korean medicine (TKM) on refractory metastatic lung cancer and small cell lung cancer (SCLC), which have historically poor survival rates. Methods : A retrospective study was conducted using the medical records of two patients in Daejeon University hospital. The first patient, with SCLC, was treated from January 2000 to December 2009 and the other, with metastatic pulmonary cancer from primary hepatocellular carcinoma (HCC), was treated from September 2004 to February 2014. The patients were treated with herbal medicines at one-month intervals. During hospitalization, acupuncture and indirect moxibustion were performed concurrent with the administration of Western therapy. Treatment efficacy was assessed monthly using chest radiography, chest computed tomography, and laboratory examination data, and by measuring patient performance status. Results : Both patients exhibited a stable disease course for more than 9 years after the initial diagnosis of intractable lung cancer, suggesting that their disease status was controlled by TKM. Conclusions : We suggest that a combination of TKM with conventional Western therapy for refractory lung cancer patients is effective in controlling various symptoms related to lung cancer and improving quality of life, and may potentially prolong overall survival.
Objectives : To evaluate the long-term survival effects of traditional Korean medicine (TKM) on refractory metastatic lung cancer and small cell lung cancer (SCLC), which have historically poor survival rates. Methods : A retrospective study was conducted using the medical records of two patients in Daejeon University hospital. The first patient, with SCLC, was treated from January 2000 to December 2009 and the other, with metastatic pulmonary cancer from primary hepatocellular carcinoma (HCC), was treated from September 2004 to February 2014. The patients were treated with herbal medicines at one-month intervals. During hospitalization, acupuncture and indirect moxibustion were performed concurrent with the administration of Western therapy. Treatment efficacy was assessed monthly using chest radiography, chest computed tomography, and laboratory examination data, and by measuring patient performance status. Results : Both patients exhibited a stable disease course for more than 9 years after the initial diagnosis of intractable lung cancer, suggesting that their disease status was controlled by TKM. Conclusions : We suggest that a combination of TKM with conventional Western therapy for refractory lung cancer patients is effective in controlling various symptoms related to lung cancer and improving quality of life, and may potentially prolong overall survival.
The patient in case 1 presented with SCLC and was prescribed herbal medicines on a daily basis from January 2000 to December 2009. HAD and PSM were routinely administered, and additional herbal medicines were administered in accordance with the patient’s general health condition (Table 1).
대상 데이터
A 58-year-old man who had been experiencing several symptoms including cough, hemoptysis, dyspnea, anorexia, and sputum, was referred to our department in January 2000. This patient was diagnosed with SCLC metastatic to the mediastinal lymph node in December, 1999 at Jeonbuk University Hospital and received a single round of chemotherapy at the time of diagnosis.
Although most of the patient’s symptoms disappeared, the dyspnea and chest discomfort worsened, and the patient was admitted to the ICU of Jeonbuk University Hospital in December 2009. At the time of admission, the chest CT showed increased pleural effusion and bone metastases in the left rib, but no interval change in tumor state (Fig.
A 49-year-old man with a 9-year history of hepatitis B was referred to our department for abdominal discomfort and general weakness due to HCC in September 2004. The patient was diagnosed with HCC at Seoul National University Hospital in May 2002 and underwent transarterial chemoembolization (TACE) at the time of diagnosis. Subsequently, the patient underwent lobectomy of the left lobe of the liver and TACE four additional times through December 2005.
A 58-year-old man who had been experiencing several symptoms including cough, hemoptysis, dyspnea, anorexia, and sputum, was referred to our department in January 2000. This patient was diagnosed with SCLC metastatic to the mediastinal lymph node in December, 1999 at Jeonbuk University Hospital and received a single round of chemotherapy at the time of diagnosis. The patient’s medical history, which included smoking, was unremarkable and any negative effect of SCLC on his performance status was relatively mild.
성능/효과
In conclusion, the two cases of refractory lung cancer presented herein indicate that combining TKM with conventional Western therapies can improve a patient’s quality of life, reduce symptoms, and may also lead to an improvement in overall survival. In terms of safety, patients who were treated with herbal medicines did not have any hepatic adverse reactions.
후속연구
The results in the present study, given the aforementioned limitations, indicate that additional case reports and clinical trials are needed to reliably prove the efficacy of TKM treatment on intractable lung cancer.
참고문헌 (19)
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96.
Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, et al. Changing epidemiology of small cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiology, and end results database. J Clin Oncol 2006;24:4539-44.
Uka K, Aikata H, Takaki S, Shirakawa H, Jeong SC, Yamashina K, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol 2007;13:414-20.
Jeong TY, Park BK, Lee YW, Cho CK, Yoo HS. Prospective analysis on survival outcomes of nonsmall cell lung cancer stages over IIIb treated with HangAm-Dan. Chin J Lung Cancer 2010;13(11):1009-15.
Park BK, Yoo HS, Lee YW, Han SW, Cho JH, Son CG, et al. Retrospective cohort analysis for lung cancer patients treated with Wheel Balance Therapy (WBT). J Korean Orient Int Med 2007;28(3):531-43.
Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the eastern cooperative oncology group. Am J Clin Oncol 1982;5:649-55.
Lee DE, Lee SY, Kim JS, Cho CK, Yoo HS , Choi SJ. Antitumor effect of HangAm-Dan (HAD) and its ingredients on Calu6 and MCF-7 human cancer cell lines. J Korean Oriental Med 2009;30(5):50-60.
Yoo HS, Kim SH, Lee YH, Cho CK, Lee KH. Two cases of endometrial cancer treated with palliative herbal medication Hangam-dan (HAD). J Korean Oriental Med 2007;28(4):176-80.
Oh YS, Oh MS, Son CG, Cho CK, Song TY. The effects of PSM on immune response. J Korean Oriental Med 2001;22(1):46-52.
Shin JW, Son JY, OH SM, Han SH, Wang JH, Cho JH, et al. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J Gastroenterol 2006;12(38):6142-8.
Sheehan J, Kondziolka D, Flickinger J, Lunsford LD. Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors. J Neurosurg (Suppl) 2005;102:247-54.
Choi JH, Yoo HS, Son CG, Cho CK. Regression of small cell lung carcinoma by herbal medicine: A case with an 8-year follow-up. J Korean Oriental Oncol 2005;10(1):87-9.
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