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NTIS 바로가기Journal of nutrition and health, v.48 no.5, 2015년, pp.390 - 397
박정은 (경희대학교 생활과학대학 식품영양학과) , 이정란 (경희대학교 생활과학대학 식품영양학과) , 정자용 (경희대학교 생활과학대학 식품영양학과)
Purpose: In this study, we investigated the effects of chronic alcohol and excessive iron intake on mitochondrial DNA (mtDNA) damage and the progression of alcoholic liver injury in rats. Methods: Twenty-four Sprague-Dawley male rats were divided into four groups (Control, EtOH, Fe, and EtOH + Fe), ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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알코올성 간질환의 감수성에 대한 특징은? | 3 알코올성 간질환 (alcoholic liver disease, ALD)은 지방간(steatosis), 지방간염 (steatohepatitis), 간염 (hepatitis), 간섬유증 (hepatic fibrosis), 그리고 간경변증 (liver cirrhosis)의 진행 단계를 거친다. 한 가지 주목할 점은 개인마다 알코올성 간 손상에 대한 감수성이 다르며, 알코올 남용자의 일부만이 간경변증과 같은 심한 간질환으로 진행된다는 점이다.4 즉, 습관적인 음주자의 대부분인 90~100%에서 알코올성 지방간이 발생하는 반면, 알코올성 간염은 10~35%에서, 알코올성 간경변증은 8~20%에서만 발생하는 것으로 보고되고 있다. | |
알코올성 간질환의 진행 단계는? | 2 국내 알코올 관련 질환에 의한 사망자 수는 한 해 4,500여명으로 알코올이 국민 건강에 미치는 영향이 매우 높아 이에 대한 관심이 필요하다.3 알코올성 간질환 (alcoholic liver disease, ALD)은 지방간(steatosis), 지방간염 (steatohepatitis), 간염 (hepatitis), 간섬유증 (hepatic fibrosis), 그리고 간경변증 (liver cirrhosis)의 진행 단계를 거친다. 한 가지 주목할 점은 개인마다 알코올성 간 손상에 대한 감수성이 다르며, 알코올 남용자의 일부만이 간경변증과 같은 심한 간질환으로 진행된다는 점이다. | |
철분이 조직의 손상을 초래하는 과정은? | 철분은 펜톤 반응에 의해 하이드록실 라디칼 등의 활성산소종 생성을 촉매하여 산화스트레스를 유발하고, 그 결과 지질 과산화, 단백질 및 DNA 산화 반응을 증가시켜 조직의 손상을 초래한다. 기존의 선행 연구에 따르면, 8주간 알코올을 만성 투여한 랫트 (rat)모델에서 간 조직의 철분 농도와 간 손상 정도에 유의적인 상관관계가 있는 것으로 나타났으며6 위내 삽관 (intragastric infusion)법으로 알코올을 연속적으로 투여한 쥐 모델에서 철분을 같이 공급해 주었을 때, 산화스트레스가 증가되고 일부 쥐의 경우 간섬유증에서 간경변증으로 이행이 관찰되었다. |
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