[논문]모낭 활성화를 통한 가감연령고본단의 모발 발모 효과

조아라; 홍승욱; 윤영준

doi:10.6114/jkood.2016.29.1.065

모낭 활성화를 통한 가감연령고본단의 모발 발모 효과
Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicle 원문보기

韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.29 no.1, 2016년, pp.65 - 80

조아라 (동국대학교 한의과대학 한방안이비인후피부과 교실) , 홍승욱 (동국대학교 한의과대학 한방안이비인후피부과 교실) , 윤영준 (발머스한의원)

Abstract ▼ AI-Helper

Objective : The purpose of this study is to report the hair regrowth effect of Gagamyeonryunggobon-dan on ICR mice from measuring the change of diverse factors.Methods : Gagamyeonryunggobon-dan was treated by oral administration with 2.5㎎/㎏/day amount for 3 weeks per mouse everyday. Hair regrowth was estimated by change of morphology, angiogenesis, hair follicle activation. The change of morphology was observed with external, internal change and sebaceous gland. Angiogenesis was estimated by image analysis, capillary distribution and angiogenic chemokine(MIP-2). Hair follicle activation was estimated by PCNA, IGF-2 and serotonin.Results : 1. Gagamyeonryunggobon-dan treated group had more and thicker hairs than the group not treated. Especially well developed sebaceous glands were seen in dermis of treated group. 2. Gagamyeonryunggobon-dan treated group had more capillaries near hair follicles of subcutaneous layer and more 2019% MIP-2 positive activity than the group not treated. 3. Gagamyeonryunggobon-dan treated group increased positive activity up to 596% in PCNA, 187% in IGF-2 and 547% in serotonin more than the group not treated.Conclusion : These results shows that Gagamyeonryunggobon-dan have the hair regrowth effect through verifying change of morphology, angiogenesis, chemokines. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.

주제어

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대상 데이터

8 week-old male ICR mice were purchased from the Korean laboratory animal center

데이터처리

After normality test, the results did not follow normal distribution. So, the results was tested with Mann-Whitney test. The statistical significance was attained when a p-value was less than 0.

성능/효과

After all the results, GM group that took Gagamyeonryunggobon-dan had more effective hair regrowth than SM group that didn’t take. It is suggested that Gagamyeonryunggobon-dan induces angiogenesis near hair follicles that stimulates hair follicles get into new anagen.
Drynariae Rhizoma42) and Sophorae Radix43) were reported that had a significant effect of hair growing and regrowth. As a result, Gagamyeonryunggobon-dan was made for improving blood supply near hair follicle and activating hair regrowth.
In conclusion, Gagamyeonryunggobon-dan should have the hair regrowth effect through inducing hair follicle activation. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.
In conclusion, Gagamyeonryunggobon-dan should have the hair regrowth effect through inducing hair follicle activation. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.
This is the study for hair regrowth effects of Gagamyeonryunggobon-dan to activate hair follicle on shaved mice. In this study, Gagamyeonryunggobon-dan(1 g/㎏/day) was taken to shaved mice for 3 weeks, then the state of hair growing, angiogenesis and hair follicle activation were investigated.
The bottom of hair follicle reaches subcutaneous layer during anagen whereas it reaches dermis during catagen and telogen25). It is suggested that more GM hair follicles reached subcutaneous layer than SM is not only to increase the number of GM hair follicles more than SM but also to increase anagen hair follicles in GM group more than SM. Therefore, it shows that Gagamyeonryunggobon-dan could improve the hair regrowth effect with increasing the number of anagen hair follicles.
IGF-2 near GM follicles are significantly measured more 187% activity than near SM. It show that Gagamyeonryunggobon-dan could improve hair regrowth effect from inducing cell proliferation near hair follicle and inducing VEGF to activate angiogenesis and hair follicles.
GM serotonin near hair follicle was significantly measured more 547% than SM. It shows that Gagamyeonryunggobon-dan could improve hair regrowth effect from increasing the density of serotonin near hair follicle that induces more blood supply in capillaries for activating hair follicles.
As the result, MIP-2 of GM group had more 2019% positive reaction than that of SM. It shows that Gagamyeonryunggobon-dan could improve hair regrowth effects from promoting angiogenesis near hair follicle that makes hair follicle activated.
It is suggested that more GM hair follicles reached subcutaneous layer than SM is not only to increase the number of GM hair follicles more than SM but also to increase anagen hair follicles in GM group more than SM. Therefore, it shows that Gagamyeonryunggobon-dan could improve the hair regrowth effect with increasing the number of anagen hair follicles.
7) was reported that Yeonryungiksugobon-dan based on Yeonryunggobon-dan had a significant effects of hair regrowth and increasing of EGF and VEGF to prescribed mice in the immunohistochemical study. Therefore, we estimated Yeonryunggobon-dan had a hair regrowth effect through adding the essence, blood and qi of liver and kidneys.
It makes hairs much more and thicker. Through all these reactions, Gagamyeonryunggobon-dan is suggested to have hair regrowth effect and expected to apply to extensive hair loss symptoms for example telogen effluvium. It could be thought to apply not only when lost hairs are more than regrown ones but also when hairs are getting thinner.

후속연구

It could be thought to apply not only when lost hairs are more than regrown ones but also when hairs are getting thinner. However, additional researches are needed to figure out the hair regrowth effect of Gagamyeonryunggobon-dan on different pathologic hair loss such as androgenic alopecia and alopecia areata.
It is thought that this fact will be investigated additionally from studying the effect of hair removal cream. In addition to, there was no study of Gagamyeonryunggobon-dan before this study so it is thought that diverse aspects of immunohistochemical studies are needed to figure out another chemokines or effects derived from Gagamyeonryunggobon-dan. It is also thought that constant try to develop new oriental medicines and remedies for alopecia is needed for many patients who suffer from alopecia.
So all chemokines (MIP-2, IGF-2, PCNA and serotonin) were measured more in SM group than in control group that took nothing. It is thought that this fact will be investigated additionally from studying the effect of hair removal cream. In addition to, there was no study of Gagamyeonryunggobon-dan before this study so it is thought that diverse aspects of immunohistochemical studies are needed to figure out another chemokines or effects derived from Gagamyeonryunggobon-dan.
However, excessive secretion of sebum could cause seborrhoeic dermatitis. Therefore, additional researches are needed to figure out other effects of Gagamyeonryunggobon-dan that makes sebaceous gland activated.

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