[논문]An analysis of a humidifier disinfectant case from a toxicological perspective

Park, Kwangsik

doi:10.5620/eht.e2016013

An analysis of a humidifier disinfectant case from a toxicological perspective 원문보기

Environmental health and toxicology : Eht, v.31, 2016년, pp.13.1 - 13.4

Park, Kwangsik (College of Pharmacy, Dongduk Women's University)

Abstract ▼ AI-Helper

An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, research on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the biomarker study to the patient because much time has passed after exposure to the humidifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.

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Of these, PHMG has been identified as the chemical substance that caused the most deaths. In surveys conducted to identify victims of the humidifier disinfectant, 22% of the research participants answered that they had used the humidifier disinfectant, and 21% complained of side effects. Citing this as evidence, a report estimated that there could be at least two million prospective victims [1].

참고문헌 (8)

1 Asian Citizen’s Center for Environment and Health Population survey of humidifier disinfectant use 2016 [cited 2016 Feb 25]. Available from: http://eco-health.org/bbs/board.php?bo_table=sub02_04&wr_id=160 (Korean)
2 Choi Y Paek D Humidifier disinfectants, unfinished stories Environ Health Toxicol 2016 31 e2016013 27384221

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3 Ostapenko YN Brusin KM Zobnin YV Shchupak AY Vishnevetskiy MK Sentsov VG Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol Clin Toxicol (Phila) 2011 49 6 471 477 21761961
4 Asiedu-Gyekye IJ Mahmood SA Awortwe C Nyarko AK A preliminary safety evaluation of polyhexamethylene guanidine hydrochloride Int J Toxicol 2014 33 6 523 531 25359731

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5 Kim HR Lee K Park CW Song JA Shin da Y Park YJ Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses Arch Toxicol 2016 90 3 617 632 25716161

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6 Kwon do Y Kim HM Kim E Lim YM Kim P Choi K Acute pulmonary toxicity and inflammation induced by combined exposure to didecyldimethylammonium chloride and ethylene glycol in rats J Toxicol Sci 2016 41 1 17 24 26763389

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7 Ohnuma-Koyama A Yoshida T Tajima-Horiuchi H Takahashi N Yamaguchi S Ohtsuka R Didecyldimethylammonium chloride induces pulmonary fibrosis in association with TGF-β signaling in mice Exp Toxicol Pathol 2013 65 7-8 1003 1009 23537712
8 Ohnuma A Yoshida T Tajima H Fukuyama T Hayashi K Yamaguchi S Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice Exp Toxicol Pathol 2010 62 6 643 651 19762220

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An analysis of a humidifier disinfectant case from a toxicological perspective 원문보기

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