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NTIS 바로가기Journal of nutrition and health, v.49 no.5, 2016년, pp.277 - 287
이민영 (한남대학교 식품영양학과) , 한정화 (한남대학교 식품영양학과) , 강명희 (한남대학교 식품영양학과)
Purpose: This study was performed to compare total phenolic contents, in vitro antioxidant capacity, and reduction effect of Korean food groups on ex vivo DNA damage in human cells and analyze correlations between each indicator. Methods: Vegetable foods in the Korean diet based the results of the K...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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활성 산소의 생성이 체내 항산화 방어 메커니즘의 능력을 초과하게 되면 어떻게 되는가? | 1 이렇게 산화된 DNA는 인체 내 많은 항산화 방어기전에 의해 DNA 손상이 제한되거나 광범위한 범위에서 DNA 복구가 이루어지기도 한다. 그러나 세포의 손상을 일으키는 ROS의 생성이 체내 항산화 방어 메커니즘의 능력을 초과하게 되면 산화 스트레스가 발생하게 되어 체내의 항산화 상태를 악화시키고 노화, 암, 심혈관계 질환 등을 발병시키는 원인이 된다.2 | |
단세포 전기 영동법은 어떻게 DNA의 손상 정도를 평가하는가? | 식품의 항산화활성을 측정하는 방법에는 in vitro 화학적 측정법들 외에 생체 세포를 이용하는 생물학적 측정법이 있으며 최근 화학적 측정결과 보다는 생물학적 측정결과가 실제 생체 내에서의 항산화활성을 더 잘 나타내 준다는 의견이 설득력을 얻고 있다.17 생체 내 깨진 DNA 단편을 염색 한 후에 전기영동에 의해 이동된 DNA의 길이를 측정하여 DNA의 손상 정도를 평가하는 단세포 전기 영동법(the single cell gel electrophoresis, comet assay)은 DNA 단일 또는 이중가닥의 손상을 세포 수준에서 평가할 수 있으므로 생체 내에서의 항산화활성을 반영 할 수 있다.18 | |
총 식사 항산화능이란? | 총 식사 항산화능 (total dietary antioxidant capacity, TDAC)이란 매일의 식사에서 섭취하는 모든 식물성 식품 및 음료의 항산화 활성의 합을 말하며, 식품으로부터 섭취하는 항산화 활성의 누적효과를 평가하는 도구로서 사용된다.13 개별 식품 또는 식품 속 특정 물질의 항산화 활성은 식사로부터 섭취하는 총 항산화능을 나타내어 주지 못하므로 단일 식품의 항산화 활성을 측정하는 것보다 총 식사 항산화능인 TDAC를 측정하는 것이 중요하다. |
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