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제안 방법
- 26) For quality evaluation of RCT, Cochrane’s risk of bias (ROB) tool was used. Each study was evaluated for 6 domains of bias: risk of selection bias in relation to adequate or inadequate random sequence generation; risk of selection bias with regard to allocation concealment; risk of performance bias in terms of blinding of participants and personnel; risk of detection bias in relation to blinding of outcome assessment; risk of attrition bias due to incomplete outcome data; and ROB from selective reporting of outcomes. The RCT was assessed for each domain and judged as “low risk,” “unclear risk,” or “high risk” based on the following definitions: ‘low’ risk, plausible bias unlikely to alter the results; ‘unclear’ risk, plausible bias that raises some doubt about the results; ‘high’ risk, plausible bias that seriously weakens confidence in the results.
- in this meta-analysis, we could not conduct a subgroup analysis stratified by statin doses because the daily doses were varied and most of studies did not report the doses according to the SLCO1B1 T521C polymorphism. In addition, the incidence of myotoxicity is also affected by medical conditions, concurrent medications, and food,15,16,50) and it is difficult to believe that all these factors were controlled because most of the studies included in the meta-analysis were retrospective studies. Lastly, this study failed to examine the effect of ethnicity on the incidence of myotoxicity because more than 63% of the participants were Caucasian and only 2.
- In this study, therefore, we investigated the association between SLCO1B1 T521C polymorphism and the incidence of statin-induced myotoxicity through a comprehensive systematic review and meta-analysis analyzing the results from 12 studies.
- 1 (Cochrane Collaboration, Oxford, United Kingdom). To assess the association between the SLCO1B1 T521C polymorphism and statin-induced myotoxicity, the weighted pooled estimates of the odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in different genetic models: dominant model (TC + CC vs TT), heterozygote contrast model (TC vs TT, CC vs TC), and homozygote contrast model (CC vs TT). If the incidences of myotoxicity were reported separately according to symptom presentation and the numbers of the subjects monitored for each symptom were different in one study, the incidences of each symptom were considered as independent outcomes from separate studies.
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