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Design and in vivo evaluation of entecavir-3-palmitate microcrystals for subcutaneous sustained delivery

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, v.130, 2018년, pp.143 - 151  

Ho, Myoung Jin (College of Pharmacy, Dankook University) ,  Lee, Dae Ro (College of Pharmacy, Dankook University) ,  Im, Sung Hyun (College of Pharmacy, Dankook University) ,  Yoon, Jeong A (College of Pharmacy, Dankook University) ,  Shin, Chang Yong (Dong-A Pharmaceutical Co. Ltd.) ,  Kim, Hyun Jung (Dong-A Pharmaceutical Co. Ltd.) ,  Jang, Sun Woo (Dong-A Pharmaceutical Co. Ltd.) ,  Choi, Young Wook (College of Pharmacy, Chung-Ang University) ,  Han, Young Taek (College of Pharmacy, Dankook University) ,  Kang, Myung Joo (College of Pharmacy, Dankook University)

Abstract AI-Helper 아이콘AI-Helper

Abstract The objectives of this study were to formulate microcrystals of entecavir-3-palmiate (EV-P), a palmitic acid ester of entecavir (EV), and evaluate the influence of particle size on its pharmacokinetic behavior following subcutaneous (SC) injection. Systemic toxicity and local tolerability ...

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