최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, v.33 no.4, 2018년, pp.337 - 344
Germinated brown rice (GBR, Orysa sartiva L.) has been reported to have anti-obesity and anti-inflammatory effects. However, the mechanisms underlying these effects in adipocytes are not fully understood. Therefore, this study was conducted to explore the anti-inflammatory mechanisms of GBR on lipop...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
지방세포가 LPS 자극을 받아 염증반응을 촉진시키는 기작은? | 2012). TLR4는 lipopolysaccharide (LPS)에 의해 자극되며, 지방세포가 LPS의 자극을 받으면 지방분해, 인슐린 저항성, 케모카인인 monocyte chemoattractantprotein-1 (MCP-1)의 분비를 증가시켜 지방조직으로 대식세포를 끌어들여 염증반응을 촉진시킨다(Kopp et al. 2009). | |
GBR 추출물 (발아현미 에탄올 추출물) 처리 농도에 따른 염증성 사이토카인의 유전자 발현 변화는? | 2. 지방세포에서 분비되는 대표적인 염증성 사이토카인인 TNF-α, IL-6, 및 MCP-1의 유전자 발현 변화를 측정한 결과, 모든 처리 농도에서 LPS 처리로 증가된 염증성 사이토카인의 유전자 발현을 유의적으로 억제하였으며, 그 효과는 농도 의존적인 경향을 보였다(p<0.05). 특히, 고농도(20 mg/mL) 처리 시 IL-6와 MCP-1의 mRNA 발현량이 LPS 무처리군과 비슷한 수준으로 억제됨을 확인하였다. | |
체내 지방조직에서 만성 염증반응의 원인이 되는 염증성 사이토카인은 무엇인가? | 그러나 과잉영양과 운동부족으로 인해 과량의 지방조직이 체내 축적되면 다양한 대사성 질환이 발병될 수 있다. 수많은 연구결과에 의하면 비만일 경우 체내 지방조직에서 tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) 등의 염증성 사이토카인의 분비가 증가되어 낮은 수준의 만성 염증반응이 지속적으로 일어나게되고 이는 인슐린 저항성과 고인슐린혈증을 야기하며 이는 결국 대사성질환의 발병과 연관된다고 한다(Paniagua 2016; Appari et al. 2018; Rada et al. |
Akira S, Uematsu S, Takeuchi O. 2006. Pathogen recognition and innate immunity. Cell, 124(4):783-801
Akira S. 2003. Mammalian Toll-like receptors. Curr. Opin. Immunol., 15(1):5-11
Appari M, Channon KM, McNeill E. 2018. Metabolic regulation of adipose tissue macrophage function in obesity and diabetes. Antioxid Redox Signal., 29(3):297-312
Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. 2010. Inhibitory role for GABA in autoimmune inflammation. Proc. Natl. Acad. Sci. USA, 107(6):2580-2585
Bui TN, Le TH, Nguyen do H, Tran QB, Nguyen TL, Le DT, Nguyen do VA, Vu AL, Aoto H, Okuhara Y, Ito Y, Yamamoto S, Kise M. 2014. Pre-germinated brown rice reduced both blood glucose concentration and body weight in Vietnamese women with impaired glucose tolerance. J. Nutr. Sci. Vitaminol.(Tokyo), 60(3):183-187
Cani PD, Delzenne NM, Amar J, Burcelin R. 2008. Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol. Biol. (Paris), 56(5):305-309
Cho DH, Lim ST. 2016. Germinated brown rice and its biofunctional compounds. Food Chem., 196:259-271
Chompoopong S, Jarungjitaree S, Punbanlaem T, Rungruang T, Chongthammakun S, Kettawan A, Taechowisan T. 2016. Neuroprotective Effects of Germinated Brown Rice in Rotenone-Induced Parkinson's-Like Disease Rats. Neuromolecular Med., 18(3):334-346
Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J, O'Brien KD, Chait A. 2012. Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese lowdensity lipoprotein receptor-deficient mice. Arterioscler Thromb. Vasc. Biol., 32(7):1596-1604
Ha SK, Sung J, Choi I, Kim Y. 2016. Oryza sativa(Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by suppressing extracellular signal-regulated kinase, c-Jun N-terminal kinase, and nuclear factor- $\kappa$ B activation. Pharmacogn. Mag., 12(48):295-301
Ho JN, Son ME, Lim WC, Lim ST, Cho HY. 2012. Anti-obesity effects of germinated brown rice extract through downregulation of lipogenic genes in high fat diet-induced obese mice. Biosci. Biotechnol. Biochem., 76(6):1068-1074
Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298(5600):1911-1912
Kopp A, Buechler C, Bala M, Neumeier M, Scholmerich J, Schaffler A. 2010. Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3. Endocrinology, 151(3):1097-1108
Kopp A, Buechler C, Neumeier M, Weigert J, Aslanidis C, Scholmerich J, Schaffler A. 2009. Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity(Silver Spring), 17(4):648-656
Lim SM, Goh YM, Kuan WB, Loh SP. 2014. Effect of germinated brown rice extracts on pancreatic lipase, adipogenesis and lipolysis in 3T3-L1 adipocytes. Lipids Health Dis, 13:169
Lim SM, Goh YM, Mohtarrudin N, Loh SP. 2016. Germinated brown rice ameliorates obesity in high-fat diet induced obese rats. BMC Complement. Altern. Med., 16:140
Lin PP, Hsieh YM, Kuo WW, Lin YM, Yeh YL, Lin CC, Tsai FJ, Tsai CH, Tsai CC, Huang CY. 2013. Suppression of TLR-4-related inflammatory pathway and anti-fibrosis effects of probiotic-fermented purple sweet potato yogurt in hearts of spontaneously hypertensive rats. Chin. J. Physiol., 56(3):174-183
Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE. 2000. The lipopolysaccharide-activated toll-like receptor(TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J. Biol. Chem. 275(32):24255-24263
Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25(4):402-408
Mellen PB, Walsh TF, Herrington DM. 2008. Whole grain intake and cardiovascular disease: a meta-analysis. Nutr. Metab. Cardiovasc. Dis., 18(4):283-290
Muhammad SI, Maznah I, Mahmud R, Zuki AB, Imam MU. 2013. Upregulation of genes related to bone formation by $\gamma$ -amino butyric acid and $\gamma$ -oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats. Clin. Interv. Aging, 8:1259-1271
Okarter N, Liu RH. 2010. Health benefits of whole grain phytochemicals. Crit. Rev. Food Sci. Nutr., 50(3):193-208
Paniagua JA. 2016. Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome. World J. Diabetes, 7(19):483-514
Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, Knauf C, Peiretti F, Verdier M, Juhan-Vague I, Tanti JF, Burcelin R, Alessi MC.(2007). C3H/HeJmice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia, 50(6):1267-1276
Rada I, Deldicque L, Francaux M, Zbinden-Foncea H. 2018. Toll like receptor expression induced by exercise in obesity and metabolic syndrome: A systematic review. Exerc Immunol Rev., 24:60-71
Shen KP, Hao CL, Yen HW, Chen CY, Chen JH, Chen FC, Lin HL. 2016. Pre-germinated brown rice prevented high fat diet induced hyperlipidemia through ameliorating lipid synthesis and metabolism in C57BL/6J mice. J. Clin. Biochem. Nutr., 59(1):39-44
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. 2006. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest., 116(11):3015-3025
Song BH, Kim DY, Kim SK, Kim YD, Choi SK. 1988. Distribution of protein, fat, and ash within the degermed brown rice kenel. J. Korean Soc. Appl. Biol. Chem., 31(2):1-6
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araujo EP, Vassallo J, Curi R, Velloso LA, Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes, 56(8):1986-1998
Tuntipopipat S, Muangnoi C, Thiyajai P, Srichamnong W, Charoenkiatkul S, Praengam K. 2015. A bioaccessible fraction of parboiled germinated brown rice exhibits a higher anti-inflammatory activity than that of brown rice. Food Funct., 6(5):1480-1488
Wu F, Chen H, Yang N, Wang J, Duan X, Jin Z, Xu X. 2013. Effect on germination time on physicochemical properties of brown rice flour and starch from different rice cultivars. J. Cereal Sci., 58(2):263-271
Wunjuntuk K, Kettawan A, Charoenkiatkul S, Rungruang T. 2016. Parboiled germinated brown rice protects against CCl4-induced oxidative stress and liver injury in rats. J. Med. Food, 19(1):15-23
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.