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Isovitexin, a Potential Candidate Inhibitor of Sortase A of Staphylococcus aureus USA300 원문보기

Journal of microbiology and biotechnology, v.28 no.9, 2018년, pp.1426 - 1432  

Mu, Dan (College of Animal Science, Jilin University) ,  Xiang, Hua (College of Animal Science and Technology, Jilin Agricultural University) ,  Dong, Haisi (College of Animal Science, Jilin University) ,  Wang, Dacheng (College of Animal Science, Jilin University) ,  Wang, Tiedong (College of Animal Science, Jilin University)

Abstract AI-Helper 아이콘AI-Helper

Staphylococcus aureus causes a broad variety of diseases. The spread of multidrug-resistant S. aureus highlights the need to develop new ways to combat S. aureus infections. Sortase A (SrtA) can anchor proteins containing LPXTG binding motifs to the bacteria surface and plays a key role in S. aureus...

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가설 설정

  • (A) The reaction solutions contained SrtA, the synthetic fluorescent peptide substrate Abz-LPATG-Dap(Dnp)-NH2 and various concentrations of isovitexin. (B) Effect of isovitexin on the growth of S. aureus. The WT strain was cultured in BHI broth with 256 μg/ml isovitexin (square) or without isovitexin (circle).
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