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NTIS 바로가기大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, v.31 no.4, 2018년, pp.54 - 72
손보길 (부산대학교 한의학전문대학원) , 이희윤 (부산대학교 한의학전문대학원) , 배주은 (부산대학교 한의학전문대학원) , 윤영진 (부산대학교 한의학전문대학원)
Objectives: The aim of this review is to investigate studies on Estrogen-like activity and to contribute to the utilization of herbal medicines including phytoestrogens. Methods: Electric searches were performed with Pubmed from 2013 to June 2018, for the words, 'herb and estrogen', 'traditional Chi...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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갱년기 여성은 에스트로겐 감소로 어떠한 증상을 겪는가? | 에스트로겐은 표적 세포내에 있는 에스트로겐 수용체와 결합하여 세포의 기능을 조절하며 자궁의 발달, 자궁 내막 및 젖샘의 발달, 지방 합성의 증가, 간 기능과 골 대사 등에 영향을 미친다1). 갱년기 여성은 에스트로겐 감소로 인하여 혈관운동증상, 인지기능 장애, 우울, 골다공증 등 다양한 증상이 나타나는데2), 이는 인위적으로 에스트로겐을 투여하여 완화될 수 있다3). | |
인위적으로 에스트로겐을 투여하는 치료의 부작용은? | 그러나 이러한 호르몬 요법의 장기 사용은 심혈관질환, 자궁내막암 및 유방암 등 심각한 부작용을 유발할 수 있다는 사실이 밝혀졌다2). 이에 에스트로겐 치료를 대신할 대안으로 식물성 에스트로겐이 주목받고 있으며4), 그 효과를 확인하고 이를 갱년기 장애의 예방 및 치료에 이용하고자 하는 연구가 활발히 진행되고 있다3). | |
에스트로겐의 역할은? | 에스트로겐은 표적 세포내에 있는 에스트로겐 수용체와 결합하여 세포의 기능을 조절하며 자궁의 발달, 자궁 내막 및 젖샘의 발달, 지방 합성의 증가, 간 기능과 골 대사 등에 영향을 미친다1). 갱년기 여성은 에스트로겐 감소로 인하여 혈관운동증상, 인지기능 장애, 우울, 골다공증 등 다양한 증상이 나타나는데2), 이는 인위적으로 에스트로겐을 투여하여 완화될 수 있다3). |
Yang SH, et al. Sex-hormone replacement effect of silkworm pupa and mixture with herbs. Korean J Food Cookery SCI. 2005;21(6):769-75.
Kang SJ, et al. Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice. Experimental And Therapeutic Medicine. 2017;13(4):1249-66.
Park SH, et al. Verification of estrogen like activities of herbal medicines using an in vitro detection system. Korean J Oriental Physiology & Pathology. 2013;27(6):752-8.
Zhao X, et al. Calycosin induces apoptosis in colorectal cancer cells, through modulating the $ER{\beta}$ /MiR-95 and IGF-1R, PI3K/Akt signaling pathways. Gene. 2016;591(1):123-8.
Park HM. The efficacy of phytoestrogen in postmenopausal women. Korean Journal of Obstetrics and Gynecology. 2007;50(3):389-415.
Sathyapalan T, et al. The Effect of Phytoestrogen on Thyroid in Subclinical Hypothyroidism: Randomized, Double Blind, Crossover Study. Frontiers in Endocrinology. 2018;9:531.
Textbook compliation committee. Herbal medicine. 3rd rev. ed. Seoul:Younglimsa. 2016.
Lee DH, et al. In Vitro Estrogenic and Breast Cancer Inhibitory Activities of Chemical Constituents Isolated from Rheum undulatum L. Molecules. 2018;23(5):1215.
Park EJ, et al. Cytotoxic effect of sanguiin H-6 on MCF-7 and MDAMB-231 human breast carcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2017;27(18):4389-92.
Wu YZ, Sun J, Wang YB. Selective estrogen receptor modulator: A novel polysaccharide from Sparganii Rhizoma induces apoptosis in breast cancer cells. Carbohydr Polym. 2017;163:199-207.
Telang NT, et al. The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the luminal a molecular subtype of breast cancer. Oncology Letters. 2017;13(4):2477-82.
Sun JQ et al. Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway. Evidence-Based Complementary and Alternative Medicine. 2016;2016:13.
Wang KL, et al. Anti-proliferative effects of evodiamine on human breast cancer cells. Plos One. 2013;8(6):e67297.
Zhang X, Zhang Y, Li Y. $\beta$ -elemene decreases cell invasion by upregulating E-cadherin expression in MCF-7 human breast cancer cells. Oncol Rep. 2013;30(2):745-50.
Zuo YH, et al. Panax ginseng polysaccharide protected H9c2 cardiomyocyte from hypoxia/reoxygenation injury through regulating mitochondrial metabolism and RISK pathway. Front. Physiol. 2018;9:699.
Que R, et al. Estrogen receptor- $\beta$ -dependent effects of saikosaponin-d on the suppression of oxidative stressinduced rat hepatic stellate cell activation. International J of Molecular Medicine. 2016;41(3):1357-64.
Liu B, et al. Calycosin inhibits oxidative stress-induced cardiomyocyte apoptosis via activating estrogen receptor- ${\alpha}/{\beta}$ . Bioorganic & Medicinal Chemistry Letters. 2016;26(1):181-5.
Zhao P, et al. Anabolic effect of traditional chinese medicine compound tanshinone II A on myotube hypertrophy is mediated by estrogen receptor. Planta Medica. 2015;81(7):578-85.
Haihong LV, et al. Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. Molecular Medicine Reports. 2015;12(2):2283-90.
Wang Y, et al. Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF- ${\kappa}B$ ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. Phytomedicine. 2014;21(8-9):1032-6.
Wang Y, et al. Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ERdependent MEK/ERK and PI3K/Akt activation. Phytomedicine. 2013;20(10):787-96.
Liu LJ, et al. Puerarin suppress apoptosis of human osteoblasts via ERK signaling pathway. International J of Endocrinology. 2013;2013:6.
Shi C, et al. Tanshinone II A promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphaticylinositol 3-kinase/Akt. Biomedical Reports. 2014;2(4):500-4.
Wang H, et al. An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response. Plos One. 2013;8(7):e69555.
Fan GW, et al. Anti-inflammatory Activity of Baicalein in LPS-Stimulated RAW264.7 Macrophages via Estrogen Receptor and NF- ${\kappa}B$ -Dependent Pathways. Inflammation. 2013;36(6):1584-91.
Ji M, et al. Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor- $\alpha$ . Journal of Steroid Biochemistry & Molecular Biology. 2013;138:421-6.
Li X, et al. Anti-hyperplasia effects of total saponins from phytolaccae radix in rats with mammary gland hyperplasia via inhibition of proliferation via inhibition of proliferation and induction of apoptosis. Front. Pharmacol. 2018;9:467.
Tang YQ, et al. Fructus ligustri lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats. BMC Complementary And Alternative Medicine. 2018;18(1):118.
Hwang YH, et al. The protective effects of alisol A 24-acetate from Alisma canaliculatum on ovariectomy induced bone loss in vivo. Molecules. 2016;21(1):74.
Fan JZ, et al. Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats. The J of The North American Menopause Society. 2016;22(12):1343-50.
Lim DK, Kim JG, Kim YT. Effects of Dietary Isoflavones from Puerariae Radix on Lipid and Bone Metabolism in Ovariectomized Rats. Nutrients. 2013;5(7):2734-46.
Cao Y, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. Plos One. 2017;12(11):e0186520.
Ju Y, Xiao B. Chemical constituents of Cyperus rotundus L. and their inhibitory effects on uterine fibroids. African Health Sciences. 2016;16(4):16.
Jiang Z, et al. Echinacoside and Cistanche tubulosa(Schenk) R, wight ameliorate bisphenol A-induced testicular and sperm damage in rats through gonad axis regulated steroidogenic enzymes. J of Ethnopharmacology. 2016;193:321-8.
Miao M, et al. Effect of Cynomorium total flavone on depression model of perimenopausal rat. Saudi J of Biological Sciences. 2017;24(1):139-48.
Wang Y, et al. Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats. J of The Neurological Sciences. 2014;339(1-2):144-8.
Xu Y, et al. Treatment with Panax ginseng antagonizes the extrogen decline in ovariectomized mice. Int J Mol Sci. 2015;15(5):7827-40.
Wei M, et al. Ovarian Failure-Resistant Effects of Catalpol in Aged Female Rats. Biol. Pharm. Bull. 2014;37(9):1444-9.
Kim HG, et al. Cyperi Rhizoma inhibits the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reduction in nigrostriatal dopaminergenic neurons in estrogendeprived mice. Journal of Ethnopharmacology. 2013;148(1):322-8.
Indran IR, et al. Selective Estrogen Receptor Modulator Effects of Epimedium Extracts on Breast Cancer and Uterine Growth in Nude Mice. Planta Med. 2014;80(1):22-8.
Cai ZL, et al. Tenuigenin ameliorates learning and memory impairments induced by ovariectomy. Physiology & Behavior. 2013;118:112-7.
Abolaji AO, et al. A safety assessment of the antimalarial herb Artemisia annua during pregnancy in wistar rats. Phytother Res. 2013;27(5):647-54.
Park JY, et al. Beneficial effects of Cirsium japonicum var. maackii on menopausal symptoms in ovariectomized rats. Food Funct. 2018;9(4):2480-9.
Wong KL, et al. A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Scientific Reports. 2015;5:10179.
Xu Y, et al. Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice. AGING. 2017;9(1):156-72.
Wang X, et al. Compounds from cynomorium songaricum with estrogenic and androgenic activities suppress the oestrogen/androgen-induced BPH process. Evidence-Based Complementary and Alternative Medicine. 2017:6438013.
Choi HM, et al. Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating $5{\alpha}$ -reductase. Scientific Reports. 2016;6:31906.
Wang C, et al. The prevention and treatment effects of tanshinone II A on oestrogen/androgen-induced benign prostatic hyperplasia in rats. Journal of Steroid Biochemistry & Molecular Biology. 2015;145:28-37.
Song SH, et al. Effects of total flavonoids from Drynariae rhizoma prevent bone loss in vivo and in vitro. Bone Reports. 2016;5:262-73.
Weng ZB, et al. Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiencyinduced osteoporosis and the possible mechanisms of action. Molecular And Cellular Endocrinology. 2015;417:103-13.
Kim MH, et al. Ameliorative effects of Schiandra chinensis on osteoporosis via activation of estrogen recoptor (ER)- $\alpha$ /- $\beta$ . Food Funct. 2015;5(7):1594-601.
Xiao HH, et al. Flavonoids from Herba epimedii selectively activate estrogen receptor alpha ( $ER{\alpha}$ ) and stimulate ER-dependent osteoblastic functions in UMR-106 cells. Journal of Steroid Biochemistry & Molecular Biology. 2014;143:141-51.
Wong KC, et al. Drynaria fortuneiderived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone. British J of Nutrition. 2014;110(3):475-85.
Li L, et al. Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Antibreast Cancer Effects by Inducing S Phase Arrest and Apoptosis. Frontiers in Pharmacology. 2016;7:128.
Brooks SC, Elizabeth RL, Herbert DS. Estrogen receptor in a human cell line(MCF-7) from breast carcinoma. J Biol Chem. 1973;248(17):6251-3.
Jerng UM, et al. Recent Studies of Breast Cancer in Traditional Chinese Medicine Journals. The J of Oriental Obstetrics & Gynecology. 2009;22(1):263-78.
Ranki HJ, et al. $17{\beta}$ -Estradiol regulates expression of KATP channels in heartderived H9c2 cells. JACC. 2002;40(2):367-74.
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