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NTIS 바로가기한국산업보건학회지 = Journal of Korean Society of Occupational and Environmental Hygiene, v.29 no.4, 2019년, pp.508 - 516
김현영 (안전성평가연구소) , 김기천 (안전성평가연구소) , 김인현 (안전성평가연구소) , 김민석 (안전성평가연구소) , 김성환 (안전성평가연구소) , 이규홍 (안전성평가연구소)
Objectives: The present study was performed to obtain acute toxicity information on glyoxal in male rats after intratracheal instillation. Methods: In order to calculate the LD50 of glyoxal using Probit analysis with SAS, the test article was one intratracheal instillation to male Sprague-Dawley rat...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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글리옥살은 무엇이며, 어떤 특징을 가지는가? | 글리옥살(glyoxal, oxaldehyde, ethanedial, CAS No.: 107-22-2)은 알데히드류계에 속하는 무색의 액상 화학물질로 밀도는 1.265 g/ml (20℃)이고, 분자량 58.02 g/mol, 녹는 점 -14℃, 끓는 점 104℃, 발화점 285℃, 증기압 2.4 mmHg (20℃), n-옥탄올/물 분배 계수 -0.85로 수용성의 특징을 가지고 있다. 글리옥살은 유기합성 원료로 사용되고 있으며 섬유, 종이, 페인트, 건축 자재 등 코팅분야와 세정제로 주로 사용된다. | |
글리옥살은 어떤 분야에서 주로 사용되는가? | 85로 수용성의 특징을 가지고 있다. 글리옥살은 유기합성 원료로 사용되고 있으며 섬유, 종이, 페인트, 건축 자재 등 코팅분야와 세정제로 주로 사용된다. 현대사회의 건축, 직물, 화장품 및 제지 산업의 발달로 글리옥살의 활용이 증가하고 있으며 소비자의 사용량도 증가할 것으로 예상된다. | |
이전 연구결과에 따르면, 글리옥살의 LC50 및 NOEL 수치는 어떠한가? | 이전 연구결과에 따르면 랫드 급성 흡입노출 반수치 사량(LC50)은 2.44 mg/L (4시간), 29일 동안의 반복 흡입노출(비부 노출, 6시간/일, 5일/주)결과 최대무작용량 (no observed effect level, NOEL)은 0.6 mg/m3 이라고 보고되었다(Hoechst AG, 1984; Hoechst AG, 1995). 미국정부산업위생전문가협의회(American Conference of Governmental Industrial Hygienists, ACGIH)의 노출기준(threshold limit value, TLV)에 따르면 사람 에게 허용되는 글리옥살의 1일 8시간 시간 가중 평균 농도 (Time weighted average, TWA)는 0. |
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