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Korean journal of clinical laboratory science : KJCLS = 대한임상검사과학회지, v.51 no.4, 2019년, pp.504 - 513
김연정 (대전대학교 식품영양학과) , 왕수경 (대전대학교 식품영양학과) , 박운규 (대전대학교 임상병리학과) , 오지혜 (대전대학교 임상병리학과) , 황석연 (대전대학교 임상병리학과)
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The purpose of this study was to determine the antidiabetic and antioxidative effects of Bitter melon on streptozotocin-induced diabetic rats. The normal and the control groups were fed an AIG -93M diet, and the Bitter melon groups were fed 1%, 2% and 3% Bitter melon powder. After two weeks, the con...
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 산화적 스트레스가 유발시킬 수 있는 질병에는 무엇이 있는가? | 고혈당은 여러 생화학적 경로로 당뇨병 환자의 산화적 스트레스에 대한 감수성을 높여 생체의 활성산소종(reactive oxygen species, ROS) 생성을 일으켜 합병증의 주된 기전으로 제시되고 있다[3-5]. 산화적 스트레스는 주요 합병증인 고혈압, 심근경색증 등 관상동맥질환, 뇌졸중을 일으키며 망막 질환으로 인한 실명, 만성신부전증 증 여러 가지 합병증 발생을 유발하며 심각한 결과를 초래할 수 있다[6]. | |
| 당뇨병이란 무엇인가? | 당뇨병은 인슐린의 분비와 그 작용 부족으로 혈액 내에 glucose가 다량 존재하여 고혈당상태에 이르게 되는 내분비계 질환이다[1]. 혈중 내 포도당이 세포 내로 들어가지 못하여 고혈당이 초래되고, 지방대사이상으로 혈중 지단백과 유리지방산의 농도 상승으로 고지혈증이 초래되면 지질 과산화에 따라 혈관 내 유리라디칼의 발생을 촉진하여 체내 방어기전 저하와 유리 라디칼에 의한 조직 손상을 야기한다. | |
| polypeptide-p가 당뇨병에 영향을 미치는 원리는 무엇인가? | 여주에 많이 함유된 파이토뉴트리엔트인 polypeptide-p는 식물 인슐린으로 알려져 있으며 체내에서 인슐린과 비슷한 작용을 하는 펩타이드의 일종이다. 식물 인슐린은 간에서 포도당의 연소를 돕고, 또한 포도당이 체내에서 재합성되지 않도록 하여 당뇨병에 효과가 있는 성분이다[7]. 여주의 과실과 종자에 주로 함유되어 있는 지용성 물질인 카란틴은 췌장의 β 세포에 작용하여 인슐린의 분비를 촉진하고 세포 내로 포도당 유입을 증가 시켜 포도당 이용을 증대시킨다. |
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