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NTIS 바로가기Journal of applied biological chemistry, v.62 no.4, 2019년, pp.361 - 366
김봉규 (Department of Forest Resources, Gyeongnam National University of Science and Technology)
Isorhamnetin 3-O-glucoside, a member of the flavonol group, has been reported to be effective for inflammatory and ulcer, as well as to alleviate diabetic complications such as neuropathy, nephropathy and retinopathy. Isorhamnetin 3-O-glucoside has been extracted from several plants. Biotransformati...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
플라보노이드이란? | 플라보노이드는 C6-C3-C6 기본골격을 가진 화합물을 통칭하는 파이토케미컬로서 페닐프로파노이드 생합성경로를 통해서 합성된다[1]. 나린제닌은 다양한 플라보노이드 합성의 전구체로 사용되는 물질로 p-coumaroyl-CoA 한분자와 malonyl-CoA 세분자가 chalcone synthase와 chalcone isomerase의 연속적인 반응으로 합성된다[2]. | |
플라보노이드의 대체생산법 중 대장균을 주로 이용하는 이유는? | 최근 이러한 문제를 극복하기 위해 식물세포 뿐만 아니라 효모, 바실러스, 스트렙토마이세스, 대장균 등과 같은 미생물을 이용한 플라보노이드의 대체생산법 등이 개발되고 있다. 특히, 대장균은 배양과 형질전환이 쉬울 뿐만 아니라 대장균 내의 생합성과정이 잘 알려져 있고 대사 조절이 가능하기 때문에 플라보노이드 생산 균주로 많이 이용한다[16-18]. | |
Isorhamnetin 3-O-glucoside을 포함하는 식물은? | Isorhamnetin 3-O-glucoside는 플라보놀 그룹에 속하는 물질로서 염증이나 궤양에 효과가 있을 뿐만 아니라 신경장해, 신장병증, 망막증과 같은 당뇨합병증을 완화하는 것으로 보고되었다. Isorhamnetin 3-O-glucoside는 Tetraena aegyptia, Salsola oppositifolia, Salicornia herbacea, Sambucus ebulus와 같은 몇몇 식물에서 발견된다. 생물전환은 저렴한 화합물로부터 고부가가치 물질을 생산할 수 있는 유용한 방법이다. |
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