Thromboelastography (TEG) analysis consists of ${\alpha}$, G, K, MA, and R types of values and tests the effectiveness of blood clotting, which can be assessed for platelet function, clotting strength, and fibrinolysis. Canine heartworm diseases caused by Dirofilaria immitis, a vascular n...
Thromboelastography (TEG) analysis consists of ${\alpha}$, G, K, MA, and R types of values and tests the effectiveness of blood clotting, which can be assessed for platelet function, clotting strength, and fibrinolysis. Canine heartworm diseases caused by Dirofilaria immitis, a vascular nematode, can lead to hyperfibrinolysis and hypercoagulation. In this study, G and MA values showed a statistically significant decrease over time after treatment of heartworm disease. Additionally, the ${\alpha}-value$ showed a high correlation with G, K, MA, and R values. The G value showed a high correlation with K and MA values, while The K value showed a high correlation with MA and R values. This study clearly found a gradual decrease in G and MA values in dogs with heartworm disease over time, both before and after treatment. This suggests that the clot formation time is longer and that the intensity of clot formation is lowered and may improve the risk of thromboembolism in dogs with heartworm disease.
Thromboelastography (TEG) analysis consists of ${\alpha}$, G, K, MA, and R types of values and tests the effectiveness of blood clotting, which can be assessed for platelet function, clotting strength, and fibrinolysis. Canine heartworm diseases caused by Dirofilaria immitis, a vascular nematode, can lead to hyperfibrinolysis and hypercoagulation. In this study, G and MA values showed a statistically significant decrease over time after treatment of heartworm disease. Additionally, the ${\alpha}-value$ showed a high correlation with G, K, MA, and R values. The G value showed a high correlation with K and MA values, while The K value showed a high correlation with MA and R values. This study clearly found a gradual decrease in G and MA values in dogs with heartworm disease over time, both before and after treatment. This suggests that the clot formation time is longer and that the intensity of clot formation is lowered and may improve the risk of thromboembolism in dogs with heartworm disease.
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제안 방법
Based on the guidelines by AHS for heartworm treatment, the patients received a total of three injections of melarsomine dihydrochloride (IMMITICIDE®, Boehringer Ingelheim, France) (2.5 mg/kg, deep intramuscular) at the lumbar epaxial muscles between 3rd and 5th lumbar vertebrae.
In this study, we collected and analyzed the blood samples four times, before and after treatment for heartworm disease (T 0-3). ‘T 0’ was the analysis result obtained before the 1st injection of melarsomine dihydrochloride for heartworm treatment; ‘T 1’ was the result of the blood sample collected one day after the 1st melarsomine dihydrochloride injection, while the 2nd injection of melarsomine dihydrochloride was given one month after the 1st injection, and the 3rd was given one day after the 2nd injection; ‘T 2’ was the result obtained one day after the 2nd injection; and ‘T 3’ was the result after the 3rd injection.
Generally, dogs infected with heartworm infection, except those with caval syndrome, receive three injections of melarsomine dihydrochloride based on the treatment guidelines by the American Heartworm Society (AHS) (15). The aim of our pilot study was to determine the time course of risk factors associated with hypercoagulation using TEG analysis over time, before and after treatment of dogs infected with heartworm, by following the standard treatment guidelines protocol by AHS.
대상 데이터
The study was conducted on client-owned dog patients of heartworm (I-III/IV Grade [Gr]) with no other disease and included 6 dogs (5 intact females and 1 castrated male, weighing 4.7-8.1 kg). All the dog patients were cross-breeds and ages were not clarified.
데이터처리
Continuous variables are presented as mean ± standard deviation (SD). Differences in the various indices that changed before and after treatment for heartworm disease were assessed using one-way analysis of variance (ANOVA). Pearson’s coefficient of bivariate correlation analysis was used to test the strength of association between each item of TEG.
Pearson’s coefficient of bivariate correlation analysis was used to test the strength of association between each item of TEG.
성능/효과
In conclusion, the evaluation of hypercoagulability after treatment of dogs with heartworm disease suggests that the clot forming time is longer and the intensity of clot formation is lowered. This may improve the risk of thromboembolism in heartworm disease in dogs.
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