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NTIS 바로가기한국수산과학회지 = Korean journal of fisheries and aquatic sciences, v.52 no.1, 2019년, pp.81 - 86
최민우 (부경대학교 식품영양학과) , 김형락 (부경대학교 식품영양학과) , 이형곤 (산안토니오텍사스주립대학교 생물학과) , 김재일 (부경대학교 식품영양학과)
The common hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD), is the presence of chronic neuroinflammation, which contributes to the loss of neuronal structure and function. This study investigated the effects of an ethanolic extract of Sargassum serratifolium (SSE)...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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주요 퇴행성 신경질환의 공통적인 병리학적 특성은? | 알츠하이머병(Alzheimer’s disease, AD), 프리온질환(priondiseases), 파킨슨병(Parkinson’s disease), 근위축성측색경화증(amyotrophic lateral sclerosis)과 같은 주요 퇴행성 신경질환(neurodegenerative disorders)의 공통적인 병리학적 특성은 신경세포의 소실(neuronal loss) 및 활성화된 미세아교세포(acti-vated microglia)가 존재한다는 것이다(Soto, 2003). 중추신경계에 상주하는 대식세포(macrophages)인 미세아교세포의 활성화는 신경염증(neuroinfammation)의 주요 특성이고, 그 분포가 퇴행성신경질환의 병리학적 병변부위에서 관찰됨으로써 이들 질환의 발병에 관여하는 것으로 알려져 있다(McGeeret al. | |
톱니모자반(Sargas-sum serratifolium)의 특징은? | , 2012). 톱니모자반(Sargas-sum serratifolium)은 한국과 일본의 연안에 광범위하게 서식하고 있고, 형태학적으로 줄기 가장자리에 끝이 가시형태를 가지고 있다는 것이 특징이다(Oak and Lee, 2006). 최근 톱니모자반의 추출물 및 함유 화합물들을 이용한 in vivo 및 in vitro 연구에서 다양한 생리활성들이 보고되었는데, 항암(anti-cancer)(Kang et al. | |
주요 퇴행성신경질환 별 뇌조직에서 관찰되는 단백질 응집물은 각각 무엇인가? | 주요 퇴행성신경질환의 공통적인 특성은 뇌조직에 단백질 응집물이 존재한다는 것이다(Soto C, 2003; Schain and Kreis l, 2017). 알츠하이머병의 경우 β-amyloid, 프리온질환의 경우 비정상적인 prion protein, 파킨슨병의 경우 α-synuclein과 같은 단백질로 이루어진 비정상적인 응집물이 관찰되고, 이러한 특성에서 각 질환들의 발병의 주요 원인물질로 알려져 있다. 이들 단백질응집들은 뇌조직에서 신경염증을 유발하는 원인물질로 작용할 수 있고, 지속적으로 축적되어 만성적인 염증을 유발함으로써 신경세포 소실에 영향을 미칠 수 있다(Soto, 2003;Schain and Kreisl, 2017). |
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