[논문]아토피성 피부로 건조함을 가진 대상자에 대한 환삼덩굴추출물 함유 기능성 화장품의 유효성 및 안전성을 평가하기 위한 임상적 연구

박혜수; 김용민; 김희택

doi:10.6114/jkood.2019.32.2.024

아토피성 피부로 건조함을 가진 대상자에 대한 환삼덩굴추출물 함유 기능성 화장품의 유효성 및 안전성을 평가하기 위한 임상적 연구
A Clinical Study for the Efficacy and Safety of Functional Cosmetics Containing Humulus japonicus Extract in Patients with Dry Skin due to Mild Atopic Dermatitis 원문보기

韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.32 no.2, 2019년, pp.24 - 58

박혜수 (세명대학교 한의과대학 한방안이비인후피부과학교실) , 김용민 (세명대학교 한방화장품과학과) , 김희택 (세명대학교 한의과대학 한방안이비인후피부과학교실)

Abstract ▼ AI-Helper

Objectives : The purpose of this study is to confirm the Efficacy and Safety of "Functional cosmetics containing Humulus japonicus Extract" on dry skin due to mild atopic dermatitis. Methods : A total of 48 patients who visited Semyung Oriental Medical Center from March 20th, 2018 to July 5th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing Humulus japonicus Extract and positive control group. For 6 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group with positive control products for control group in recovering the dry skin barriers by mild atopic dermatitis. Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase and Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 6 weeks. 2. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between Baseline and 3 weeks, but TEWL showed no statistical significance. 3. In the secondary endpoint, Skin Hydration showed a statistically significant increase in treatment group between 3 weeks and 6 weeks, but TEWL showed no statistical significance. 4. In the secondary endpoint, Change of Skin Hydration and TEWL between treatment and control group showed a statistical significance in 6 weeks. 5. In the secondary endpoint, Change of Skin Hydration of 1cm below the medial aspect of the elbow between treatment and control group showed a statistical significance in 3 weeks. 6. In the secondary endpoint, Change of Skin Hydration between treatment and control group showed a statistical significance in 3 weeks and 6 weeks except Center between the medial aspect of the elbow and the wrist in 3 weeks, and Change of TEWL between treatment and control group showed a statistical significance in 6 weeks. 7. To evaluate the safety of the products for the human body, Adverse events, EASI Score, Itching Symptoms Assessment, vital sign check were conducted; There were no severe adverse events during this study. And both experimental group and control group showed no abnormal level. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that "Functional cosmetics containing Humulus japonicus Extract" should be effective for dry skin due to mild atopic dermatitis.

주제어

표/그림 (45)

표 Table 1. Composition of PB301 lotion and Positive Control
표 Table 2. Schedule of Clinical Trial
표 Table 3. Distribution Chart of Participants
표 Table 4. Distribution of Sex, Antecedent Drug, Age, Height and Weight
표 Table 5. Change of Skin Hydration between Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 6. Change of Skin Hydration between Baseline and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 7. Change of Transepidermal Water Loss(TEWL) between Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 8. Change of Transepidermal Water Loss(TEWL) between Baseline and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 9. Change of Skin Hydration in Treatment Group between Baseline and 3 weeks(1㎝ below the medial aspect of the elbow)
표 Table 10. Change of Skin Hydration in Treatment Group between Baseline and 3 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 11. Change of Transepidermal Water Loss(TEWL) in Treatment Group between Baseline and 3 weeks(1㎝ below the medial aspect of the elbow)
표 Table 12. Change of Transepidermal Water Loss(TEWL) in Treatment Group between Baseline and 3 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 13. Change of Skin Hydration in Treatment Group between 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 14. Change of Skin Hydration in Treatment Group between 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 15. Change of Transepidermal Water Loss(TEWL) in Treatment Group between 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 16. Change of Transepidermal Water Loss(TEWL) in Treatment Group between 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 17. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 18. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 19. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 20. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 21. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 3 weeks(1㎝ below the medial aspect of the elbow)
표 Table 22. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 3 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 23. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline and 3 weeks(1㎝ below the medial aspect of the elbow)
표 Table 24. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline and 3 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 25. Change of Skin Hydration between Treatment Group and Control Group in 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 26. Change of Skin Hydration between Treatment Group and Control Group in 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 27. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 28. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 29. Change of Skin Hydration between Treatment Group and Control Group in Baseline, 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
그림 Fig. 1. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
그림 Fig. 2. Change of Skin Hydration between Treatment Group and Control Group in Baseline and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 30. Change of Skin Hydration between Treatment Group and Control Group in Baseline, 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
그림 Fig. 3. Change of Transepidermal Water Loss (TEWL) between Treatment Group and Control Group in Baseline and 6 weeks(1㎝ below the medial aspect of the elbow)
그림 Fig. 4. Change of Transepidermal Water Loss TEWL) between Treatment Group and Control Group in Baseline and 6 weeks Center between the medial aspect of the elbow and the wrist)
표 Table 31. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline, 3 weeks and 6 weeks(1㎝ below the medial aspect of the elbow)
표 Table 32. Change of Transepidermal Water Loss(TEWL) between Treatment Group and Control Group in Baseline, 3 weeks and 6 weeks(Center between the medial aspect of the elbow and the wrist)
표 Table 33. Adverse Events
표 Table 34. Change of EASI Score
표 Table 35. Change of itching Symptoms
표 Table 36. Change of the Frequency of Itching Symptoms
표 Table 37. Change of the Duration of itching Symptoms
표 Table 38. Change of Systolic Blood Pressure
표 Table 39. Change of Diastolic Blood Pressure
표 Table 40. Change of Pulse
표 Table 41. Change of Body Temperature

질의응답

핵심어	질문	논문에서 추출한 답변
	아토피 피부염의 임상 양상은 어떤 것들이 있는가?	임상 양상은 유아기(생후 2개월~2세 미만)의 경우 얼굴·두피·사지의 신측 부위에 급성 병변으로 인설을 동반하거나 동반하지 않는 홍반성 반·가피·삼출액을 동반한 습윤성 반점 등이 나타나고, 소아기(2~12세 미만)의 경우 주관절과 슬관절 등의 굴측부에 홍반을 동반한 인설과 가피 및 태선화의 형태가 나타나며, 청소년기와 성인기(12세~)의 경우 주로 얼굴·목·두피에 만성형의 피부 습진과 홍반이 나타난다5).
	서양의학에서 아토피 피부염의 치료법에는 어떤 것들이 있는가?	서양의학에서는 습도 및 온도를 유지하여 피부의 건조를 예방하는 등의 대증요법과 함께 국소치료로서 부신피질 호르몬·면역조절제·항생제·항진균제·항바이러스제 등을 도포하며, 국소 도포에 반응이 없는 병변에는 전신 요법으로서 항히스타민제·부신피질 호르몬 제·항생제·항진균제·Cyclosporine 등의 경구투여와 면역글로불린의 정맥 주사, 광선 치료와 탈감작 요법 혹은 달맞이꽃 종자유를 포함한 음식 혹은 약제 투여 등 다양한 치료법이 개발되어 사용되고 있다5,6) .
	아토피 피부염은 무엇인가?	아토피 피부염(Atopic dermatitis)은 심한 가려움 등을 특징으로 호전과 악화를 반복하는 만성 재발성 피부염으로, 주로 영·유아기, 특히 생후 2개월 전후 (약 10%)에서 많이 나타났지만 근래에 이르러서는 연령을 불문하고 성인(약 3%)에서도 많이 나타난다1,2) . 아토피 피부염의 원인은 현재까지 정확한 기전이 밝혀지지 않았으나 유전적, 환경적, 면역학적 요인과 감염, 위생 가설, 혈관 이상, 피부 장벽 이상 등이 있으며 여러 가지 인자간의 상호작용이 관여하며 최근 환경적 인자의 요인으로 세계적인 유병률은 증가 추세에 있다1-4) .

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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