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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.34 no.3, 2019년, pp.45 - 53
이지혜 (대구한의대학교 한의과대학 본초학교실) , 구진숙 (안동대학교 자연과학대학 생약자원학과) , 노성수 (대구한의대학교 한의과대학 본초학교실) , 박지하 (대구한의대학교 한의과대학 본초학교실) , 서부일 (대구한의대학교 한의과대학 본초학교실)
Objectives : In present study, we investigated a therapeutic effect of Astragali Radix on hypothyroidism rat model induced by 6-Propyl-2-thiouracil (PTU). Methods : Six-week-old male Sprague-Dawley rats were divided into five groups : Group one included the normal mice. Group two was administrated P...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
갑상선기능저하증이란? | 갑상선기능저하증이란 갑상선호르몬이 부족한 대사상태로 주로 여성에게서 호발하는 질환이다1). 갑상선호르몬 결핍은 갑상선 조직의 소실로 호르몬의 생합성이 불가능하거나, 상위 조절중추인 뇌하수체 또는 시상하부의 기능이상으로 인해 갑상선 자극원이 사라져 발생하며, 임상증상은 병증의 정도에 따라 매우 다양하나 전형적 증상으로 쇠약감, 피로, 내한성감소, 체중증가, 무력감, 식욕감퇴, 기억력 감퇴, 발한감소, 관절통, 근육통 및 변비 등이 나타난다2-4). | |
갑상선기능저하증 치료 치환요법의 단점은? | 갑상선기능저하증 치료의 목표는 말초조직에서의 갑상선호르몬 수치를 정상화하는 것으로, liothyronine (T3)제제, thyroxine (T4)제제 또는 thyroxine-liothyronine 복합제제를 투여하는 갑상선호르몬 치환요법이 사용되고 그 중에서도 T4제제의 투여가 가장 많이 이용되고 있다5). 하지만 이런 호르몬 보충요법은 평생 약물을 복용해야 한다는 불편함이 있을 뿐 아니라, 약물 복용 후에 호르몬 수치는 정상이지만 증상은 호전되지 않는 등의 문제가 발생할 수 있다6). 또한 과량의 levothyroxine (LT4)투여로 불안정성 협심증이나 급성 심근경색 등의 허혈성 심질환이나 골다공증의 위험성이 증가한다는보고도 있다1,6). | |
갑상선호르몬 결핍이 나타나는 원인은? | 갑상선기능저하증이란 갑상선호르몬이 부족한 대사상태로 주로 여성에게서 호발하는 질환이다1). 갑상선호르몬 결핍은 갑상선 조직의 소실로 호르몬의 생합성이 불가능하거나, 상위 조절중추인 뇌하수체 또는 시상하부의 기능이상으로 인해 갑상선 자극원이 사라져 발생하며, 임상증상은 병증의 정도에 따라 매우 다양하나 전형적 증상으로 쇠약감, 피로, 내한성감소, 체중증가, 무력감, 식욕감퇴, 기억력 감퇴, 발한감소, 관절통, 근육통 및 변비 등이 나타난다2-4). |
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